Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Electric Literature of 20099-89-2.
Musci, Pantaleo;Colella, Marco;Andresini, Michael;Aramini, Andrea;Degennaro, Leonardo;Luisi, Renzo research published 《 Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry》, the research content is summarized as follows. The use of flow technol. as an enabling tool for accessing 1-azabicyclo[1.1.0]butanes bearing strained 3-, 4-, and 5-membered O-heterocycles with C3(N-het)-C2(O-het) connectivity I [R = H, Me, CH2CH2Br, etc.; R1 = Ph, 2-ClC6H4, CH:CHC6H5, etc.], II [X = 1, 2; R2 = Ph, 2-thienyl, 2-naphthyl, etc.] and III [n = 2, 3; R3 = Ph, 4-BrC6H4, 1-naphthyl, etc.] was reported. Reactivity and chemoselectivity (N-ring vs. O-ring) were also evaluated. New chem. space was explored and new structural motifs such as ABB-aziridines IV [n = 1, 2, 3; R4 = Boc, Ts; R5 = Cl, Br, SPh, etc.; Ar = Ph, 4-FC6H4, 4-MeC6H4, 4-OMeC6H4] or spiro azetidine-oxazetidine V were also reported.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Electric Literature of 20099-89-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts