Oliveira, Nereu Junio Candido team published research in Journal of Molecular Structure in 2022 | 20099-89-2

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Electric Literature of 20099-89-2

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Electric Literature of 20099-89-2.

Oliveira, Nereu Junio Candido;Teixeira, Iasmin Natalia Santos;Fernandes, Philipe Oliveira;Verissimo, Gabriel Correa;Valerio, Aline Dias;Moreira, Carolina Paula de Souza;Freitas, Tulio Resende;Fonseca, Anna Clara Ventura;Sabino, Adriano de Paula;Johann, Susana;Maltarollo, Vinicius Goncalves;de Oliveira, Renata Barbosa research published 《 Computer-aided molecular design, synthesis and evaluation of antifungal activity of heterocyclic compounds》, the research content is summarized as follows. In this perspective, heterocyclic compounds namely thiazolylhydrazones I [R1 = H, Me, F, Cl, CN; R2 = CHt-Bu, CMe(CH2)2OH, etc.], furans II [R1 = Cl, NO2], tetrazoles III [R1 = Me, NO2; R2 = CH2CH2OH, cyclohexyl, (CH2)3CH2OH, (CH2)5CH2OH], triazole IV [R1 = (CH2)3CH2OH, (CH2)5CH2OH] and thiadiazoline derivatives were synthesized and tested in vitro against seven clin. importance Cryptococcus and Candida species. In this study, virtual screening techniques were applied using a scaffold-hopping database, FDA approved drugs and a ZINC subset. Some of the compounds evaluated showed promising antifungal activity against C. albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. neoformans and C. gatti, displaying minimal inhibitory concentration (MIC) values in the range of 0.12-250μM.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Electric Literature of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts