Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Category: nitriles-buliding-blocks.
Osmaniye, Derya;Gorguelue, Sennur;Saglik, Beguem Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Synthesis and biological evaluation of novel 1,3,4-oxadiazole derivatives as anticancer agents and potential EGFR inhibitors》, the research content is summarized as follows. Herein, novel quinoxalin-oxadiazole derivatives I (R1 = H, F, Cl; R2 = H, CH3, CN, etc.) were synthesized as EGFR inhibitors in this study. Synthesis of compounds I was performed according to the literature methods. Structure elucidation was performed for compound I (R1 = H; R2 = NO2) using 2D NMR technique. MTT test was performed to assess the cell proliferation effects of the different compounds on lung and mammary cell lines (A549, MCF7). In addition, obtained compounds I were screened against healthy CCD19-Lu cell line (human lung fibroblast normal cells) to determine selectivity of the cytotoxic activities. Among the tested compounds, I (R1 = H; R2 = NO2) and I (R1 = Cl; R2 = Cl) showed significant cytotoxic activity against A549 cancer cell. Moreover, compound I (R1 = H; R2 = Cl) and I (R1 = H; R2 = Br) displayed good activity. And the compounds I (R1 = H; R2 = NO2) and I (R1 = Cl; R2 = Cl) performed significant EGFR inhibition. Interaction modes of the compounds I (R1 = H; R2 = NO2), I (R1 = Cl; R2 = Cl) were investigated against EGFR tyrosine kinase by means of docking studies. As a result of the studies, the importance of the quinoxaline ring and the NO2 substituent has been understood. The activity can be contributed by using other heterocyclic rings instead of the oxadizaole ring.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts