Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Quality Control of 105-34-0.
Zanin, Lucas Lima;Jimenez, David Esteban Quintero;de Jesus, Matheus Pereira;Diniz, Luan Farinelli;Ellena, Javier;Porto, Andre Luiz Meleiro research published 《 Synthesis and X-ray crystal structures of polyfunctionalized 4H-chromene derivatives via tricomponent reaction with Knoevenagel adducts as intermediates in aqueous medium》, the research content is summarized as follows. The synthetic methodologies to obtain 4H-chromene derivs was described. Two routes were investigated, the first being a bicomponent reaction using Knoevenagel adducts as reagents and the second using one-pot tricomponent reactions, both under microwave irradiation, using H2O as solvent and triethylamine as catalyst. Twenty 4H-chromene derivatives were synthesized with 50-95% yields from aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexadione and malononitrile or Me cyanoacetate, being further characterized by Fourier Transform IR and NMR. The three crystal structures from the synthesized chromene derivatives, by single-crystal X-ray diffraction, showed the main supramol. features of each structure – a poorly unexplored approach involved this class of compounds so far was reported.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Quality Control of 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts