Month: October 2022

Campbell, Mark W.’s team published research in Journal of the American Chemical Society in 2021 | CAS: 105942-08-3

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Formula: C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Campbell, Mark W.; Yuan, Mingbin; Polites, Viktor C.; Gutierrez, Osvaldo; Molander, Gary A. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Photochemical C-H Activation Enables Nickel-Catalyzed Olefin Dicarbofunctionalization》.Formula: C7H3BrFN The article contains the following contents:

Herein, the implementation of efficient, sustainable, diaryl ketone hydrogen-atom transfer (HAT) catalysis to activate native C-H bonds for multicomponent dicarbofunctionalization of alkenes was reported. The ability to forge new carbon-carbon bonds between reagents typically viewed as commodity solvents provided a new, more atom-economic outlook for organic synthesis. Through detailed exptl. and computational investigation, the critical effect of hydrogen bonding on the reactivity of this transformation was uncovered. In the experimental materials used by the author, we found 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Formula: C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Szukalski, Adam’s team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2019 | CAS: 17201-43-3

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Product Details of 17201-43-3

In 2019,Journal of Materials Chemistry C: Materials for Optical and Electronic Devices included an article by Szukalski, Adam; Moffa, Maria; Camposeo, Andrea; Pisignano, Dario; Mysliwiec, Jaroslaw. Product Details of 17201-43-3. The article was titled 《All-optical switching in dye-doped DNA nanofibers》. The information in the text is summarized as follows:

All-optical switches are introduced which are based on DNA (DNA) in the form of electrospun fibers, where DNA is semi-intercalated with a push-pull, luminescent nonlinear pyrazoline derivative Optical birefringence is found in the organic nanofibers, with fully reversible switching controlled through continuous-wave laser irradiation The photoinduced signal is remarkably large, with birefringence highlighted by optically-driven refractive index anisotropy approaching 0.001. Sub-millisecond characteristic switching times are found. Integrating dye-intercalated DNA complex systems in organic nanofibers, as a convenient and efficient approach to template mol. organization and control it by external stimuli, might open new routes for realizing optical logic gates, reconfigurable photonic networks and sensors through phys.-transient biopolymer components.4-Cyanobenzyl bromide(cas: 17201-43-3Product Details of 17201-43-3) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Product Details of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Maurya, Shiv Shyam’s team published research in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2019 | CAS: 17201-43-3

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Recommanded Product: 4-Cyanobenzyl bromide

The author of 《Synthesis of 1,3,4-oxadiazole and imidazo[1,2-a]pyridine based molecular hybrids and their in vitro antituberculosis and cytotoxicity studies》 were Maurya, Shiv Shyam; Gosain, Tannu Priya; Kidwai, Saqib; Singh, Ramandeep; Rawat, Diwan S.. And the article was published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2019. Recommanded Product: 4-Cyanobenzyl bromide The author mentioned the following in the article:

A library of novel 1,3,4-oxadiazole substituted imidazo[1,2-a]pyridine based mol. hybrids I (R = Br, Cl, Me; R1 = 2-nitrobenzyl, naphthalen-1-ylmethyl, (E)-geranyl, etc.) have been synthesized and evaluated against mycobacterium tuberculosis H37Rv. Out of 59 compounds synthesized, ten compounds show activity in the range of 3.125-12.5 μM. Compound I (R = Br, R1 = hexyl) is found to be most active with MIC99 value of 3.125-6.25 μM. Further, these ten compounds have also been tested for their toxicity against THP-1 cell line and are found to be non-toxic with TC50 value in the range of (10 – >50 μM) concentration The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Recommanded Product: 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mondal, Buddhadeb’s team published research in Organic & Biomolecular Chemistry in 2019 | 21667-62-9

Organic & Biomolecular Chemistry published new progress about Alkadienones Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Mondal, Buddhadeb; Balha, Megha; Pan, Subhas Chandra published the artcile< Organocatalytic asymmetric spirocyclization reactions of cyclic 2,4-dienones with cyanoketones: synthesis of spiro-dihydropyrano cyclohexanones>, COA of Formula: C9H6ClNO, the main research area is cyclic dienone cyanoketone cinchona alkaloid organocatalyst spirocyclization; spiro dihydropyrano cyclohexanone diastereoselective enantioselective preparation.

The first organocatalytic asym. synthesis of spiro-dihydropyrano cyclohexanones was developed via the cascade reaction between cyanoketones and cyclic 2,4-dienones. A cinchona alkaloid-derived bifunctional primary amine catalyst in combination with N-Boc-tleucine was found to be the most effective for this spirocyclization reaction and provided the desired products in moderate to good yields with high enantioselectivities.

Organic & Biomolecular Chemistry published new progress about Alkadienones Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, COA of Formula: C9H6ClNO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abou Elmaaty, Tarek’s team published research in Journal of Supercritical Fluids in 2022-01-31 | 21667-62-9

Journal of Supercritical Fluids published new progress about Antimicrobial agents. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Name: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Abou Elmaaty, Tarek; Elsisi, Hanan; Negm, Elham; Ayad, Seif; Sofan, Mamdouh published the artcile< Novel nano silica assisted synthesis of azo pyrazole for the sustainable dyeing and antimicrobial finishing of cotton fabrics in supercritical carbon dioxide>, Name: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is nano silica azo pyrazole dye synthesis cotton fabric dyeing; disperse reactive dye supercritical carbon dioxide antimicrobial finishing.

A new protocol was developed for the synthesis of azo pyrazole derivatives via one-pot reaction of β-ketonitriles and Ph hydrazines in the presence of nano SiO2 as a mild catalyst. The synthesized dyes were elucidated using spectrophotometry, mainly NMR, FTIR, UV as well as elemental anal. The dyeing was carried out utilizing supercritical carbon dioxide as a green medium. Outstanding deep color shades and excellent dye fixation were exhibited by all new dyes. Furthermore, the dyed samples revealed superlative color fastness. The biol. evaluation of both the dyestuffs and the dyed samples showed overgrowing antimicrobial activity against the tested microorganisms. Therefore, our findings assured that disperse reactive dyes are the most com. appropriate materials for dyeing cotton in supercritical carbon dioxide.

Journal of Supercritical Fluids published new progress about Antimicrobial agents. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Name: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gore, Babasaheb Sopan’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | 21667-62-9

Chemical Communications (Cambridge, United Kingdom) published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Application In Synthesis of 21667-62-9 .

Gore, Babasaheb Sopan; Kuo, Chiao-Ying; Wang, Jeh-Jeng published the artcile< Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,1'-indene] derivatives>, Application In Synthesis of 21667-62-9 , the main research area is diaryl spiro furan indene preparation regioselective chemoselective stereoselective; isocyanide enyne spirocyclization photocatalysis nickel iridium atom economy.

An atom-economic, efficient, and highly convenient construction of spiro[furan-3,1′-indene] skeletons from isocyanides and 1,5-enynes by synergistic nickel- and iridium-photocatalysis is reported. Spirocyclization was developed under practical and mild conditions, which features excellent functional group tolerance, gram-scale synthesis and representative synthetic transformations for the obtained products and broad substrate scope. Primary mechanistic studies demonstrated that the reaction proceeds through energy-transfer-mediated excitation of intermediate catalytic species.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Application In Synthesis of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Roessler, Simon L’s team published research in Angewandte Chemie, International Edition in 2019 | 38487-85-3

Angewandte Chemie, International Edition published new progress about Amination (pyridination). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Recommanded Product: 2-Amino-4-methoxybenzonitrile.

Roessler, Simon L.; Jelier, Benson J.; Tripet, Pascal F.; Shemet, Andrej; Jeschke, Gunnar; Togni, Antonio; Carreira, Erick M. published the artcile< Pyridyl Radical Cation for C-H Amination of Arenes>, Recommanded Product: 2-Amino-4-methoxybenzonitrile, the main research area is amination arene pyridinium triflate visible light photocatalysis mechanism; amination; late-stage functionalization; photoredox catalysis; pyridyl radical cation; radical mechanism.

Electron-transfer photocatalysis provides access to the elusive and unprecedented N-pyridyl radical cation from selected N-substituted pyridinium reagents. The resulting C(sp2)-H functionalization of (hetero)arenes furnishes versatile intermediates for the development of valuable aminated aryl scaffolds. Mechanistic studies that include the first spectroscopic evidence of a spin-trapped N-pyridyl radical adduct implicate SET-triggered, pseudo-mesolytic cleavage of the N-X pyridinium reagents mediated by visible light.

Angewandte Chemie, International Edition published new progress about Amination (pyridination). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Recommanded Product: 2-Amino-4-methoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Patterson, Andrew W’s team published research in Journal of Organic Chemistry in 2008-06-20 | 6136-93-2

Journal of Organic Chemistry published new progress about Alkylation. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Related Products of 6136-93-2.

Patterson, Andrew W.; Peltier, Hillary M.; Ellman, Jonathan A. published the artcile< Expedient Synthesis of N-Methyl Tubulysin Analogues with High Cytotoxicity>, Related Products of 6136-93-2, the main research area is asym synthesis methyl tubulysin analog alkylation acylation heterocyclization esterification.

An optimized and highly efficient synthesis of potent, bioactive N-Me tubulysin analogs I and II has been achieved with > 40% overall yields. This synthesis represents a significant improvement over previously reported syntheses of these and related tubulysin analogs. The stereoselective synthesis of the unnatural amino acid tubuvaline is accomplished using tert-butanesulfinamide chem. N-Alkylation to form N-Me tubuvaline is performed without protection of the tubuvaline alc. by implementing a unique N-methylation strategy via formation and reduction of a 1,3-tetrahydrooxazine heterocycle. Acylation of the hindered N-Me tubuvaline amine utilizes a novel sequence of O-acylation followed by an O- to N-acyl transfer to form the hindered amide bond between N-Me tubuvaline and isoleucine. This high-yielding synthesis should enable the production of large quantities of material for biol. studies.

Journal of Organic Chemistry published new progress about Alkylation. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Related Products of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gore, Babasaheb Sopan’s team published research in Green Chemistry in 2021 | 21667-62-9

Green Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Gore, Babasaheb Sopan; Lin, Jun-Hao; Wang, Jeh-Jeng published the artcile< Unraveling innate substrate-controlled arylation and bicyclization of 1,5-enynes with α,β conjugates: synthesis of substituted benzo[a]fluorenes>, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is enyne unsaturated ketone arylation arene cyclization Friedel Crafts; benzofluorene aryl regioselective preparation green chem.

A strategy for the aromatic C-H functionalization of electron-rich arenes, such as anisole, phenol, veratrol, toluene or naphthalene, with 1,5-enynes anchored by conjugates, e.g., I (X = CN, EtO2C, Ts, PhCO; R1 = n-Bu, Ph, 3-FC6H4, etc.; R2 = H, 4-Me, 5-F, 4-MeO, etc.; R3 = H, 4-Cl, 3-F, 3-Br, etc.) catalyzed by a Bronsted acid under metal- and solvent-free conditions has been developed. A diverse range of benzo[a]fluorenes, e.g., II [R4 = 4-MeOC6H4, 4-HOC6H4, 3,4-(MeO)2C6H3] [from I (X = CN)] or III (R4 = 4-MeOC6H4, 4-MeC6H4, 1-naphthyl), was obtained in moderate to good yields by using this protocol. This process includes intermol. nucleophilic arene insertion or 6-exo-dig cyclization (depending on the nature of the substrates) followed by a Friedel-Crafts-type reaction and 1,5-H transfer or intermol. nucleophilic arene insertion, resp. In addition, reactions with heterocyclic compounds such as (E)-2-benzoyl-3-(2-(phenylethynyl)pyridin-3-yl)acrylonitrile proceeded smoothly and afforded 11-phenyl-11H-indeno[1,2-h]quinoline-6-carbonitrile. Moreover, solvent recycling experiments were successfully carried out to illustrate green pathways. These reactions feature a readily accessible starting materials, transition metal-free approaches, simple one-pot operations, gram-scale syntheses and wide functional group tolerance.

Green Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Recommanded Product: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Huan’s team published research in Synlett in 2020-12-31 | 38487-85-3

Synlett published new progress about Acrylamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Application In Synthesis of 38487-85-3.

Sun, Huan; Jiang, Yue; Lu, Ming-Kun; Li, Yun-Yun; Li, Li; Liu, Ji-Kai published the artcile< Iron-Catalyzed Tandem Radical Addition/Cyclization: Highly Efficient Access to Methylated Quinoline-2,4-diones>, Application In Synthesis of 38487-85-3, the main research area is methyl quinoline dione preparation; cyanoaryl acrylamide dimethyl sulfoxide photochem methylation iron catalyst.

A visible-light-induced and iron-catalyzed oxidative radical addition/cyclization cascade reaction of N-(o-cyanoaryl)acrylamides I [R1 = 4-Cl, 5-CF3, 3-Br, etc.; R2 = Me, Bn; R3 = Me, [(2,2-dimethylpropanoyl)oxy]methyl, Bn, Ph, (acetyloxy)methyl, (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl] with DMSO has been developed. The method exhibits a wide substrate scope and an excellent functional-group tolerance, thus providing an efficient and convenient access to a variety of methylated quinoline-2,4-diones II (R4 = 6-Cl, 6-CF3, 5-Br, etc.).

Synlett published new progress about Acrylamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Application In Synthesis of 38487-85-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts