Month: October 2022

Moderhack, Dietrich published the artcile< N-unsubstituted tetrazolocarboxaldehyde>, Application In Synthesis of 6136-93-2, the main research area is tetrazolecarboxaldehyde; aldehyde tetrazolyl.

The title compound was prepared by the cyclization of (EtO)2CHCN with N3H in the presence of pyridine to give I [R = CH(OEt)2], which was treated with HCl to give the aldehyde, which exists in the solid form as the dimer II. Upon dissolving in dry Me2SO at 80°, II gave 90% I (R = CHO), which undergoes most of the normal aldehyde reactions, e.g., aldol condensation. Reaction of I (R = CHO) with piperidine gave the unstable salt III, which upon exposure to air gave IV.

Chemiker-Zeitung published new progress about 6136-93-2. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application In Synthesis of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sanchez-Viesca, F.; Gomez, M. R. published the artcile< Anomalous Hoesch reaction>, Category: nitriles-buliding-blocks, the main research area is Hoesch reaction ethoxyacetonitrile; methane methoxyphenyl; acetonitrile ethoxy Hoesch reaction; methoxybenzene Hoesch reaction ethoxyacetonitrile; acetophenone dichlorotrimethoxy reaction.

Treating 1,2,4-trimethoxybenzene (I) with (EtO)2CHCN gave II instead of the Hoesch product III (R = R1 = EtO)(IV). Similar treatment of I with EtOCH2CN gave III (R = H, R1 = Cl). IV could not be prepared from III (R = R1 = Cl).

Revista Latinoamericana de Quimica published new progress about 6136-93-2. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hou, Chuanwei; He, Qian; Yang, Chunhao published the artcile< Direct Synthesis of Diverse 2-Aminobenzo[b]thiophenes via Palladium-Catalyzed Carbon-Sulfur Bond Formation Using Na2S2O3 as the Sulfur Source>, SDS of cas: 886761-96-2, the main research area is diverse aminobenzothiophene synthesis palladium catalyzed carbon sulfur bond formation; sodium thiosulfate sulfur source aminobenzothiophene synthesis.

A novel and direct synthesis of various 2-aminobenzo[b]thiophenes has been developed. The reactions were catalyzed by a combination of Pd(dppf)Cl2 and dppf using odorless and cheap Na2S2O3 as the sulfur source. This strategy allowed us to synthesize important 2-aminobenzo[b]thiophene scaffold more efficiently and conveniently. Thus, e.g., sulfuration of (2-bromophenyl)acetonitrile with Na2S2O3 in presence of Pd(dppf)Cl2 and dppf afforded 2-aminobenzothiophene in up to 64% yield.

Organic Letters published new progress about Acetylation (nucleophilic substitution of dimethylamine formed in situ from DMF under attempted acetylation conditions). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, SDS of cas: 886761-96-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Yitao; Yao, Wenqiang; Lin, Jian; Gao, Guoliang; Huang, Chang; Wu, Yang published the artcile< Design, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi>, Computed Properties of 94087-40-8, the main research area is phenyloxadiazole preparation antifungal activity.

A novel series of picarbutrazox-inspired oxadiazole hybrids I (R = 4-cyanophenyl, 3,5-dibromophenyl, 3,5-dichloro-4-(3-methoxyphenoxy)phenyl, etc.) was synthesized and the derivatives’ biol. activity against phytopathogenic fungi was investigated. The mols. were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment I. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative I can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection.

Monatshefte fuer Chemie published new progress about Agrochemical fungicides. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Computed Properties of 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lai, Miao; Su, Fangyao; Hu, Jingyi; Wang, Mengzhuo; Zhao, Mingqin; Zhang, Ganlin published the artcile< Synthesis of N-heteroarenemethyl esters via C-C bond cleavage of acyl cyanides under transition metal-free conditions>, Synthetic Route of 21667-62-9, the main research area is heteroarenemethyl ester acyl cyanide transition metal free condition; C-C bond cleavage; N-heteroaryl esters; N-heteroaryl methanols; acyl cyanides; transition-metal free synthesis.

A practical method to synthesize N-heteroaryl esters from N-heteroaryl methanols with acyl cyanides via C-C bond cleavage without using any transition metal is demonstrated here. The use of Na2CO3/15-crown-5 couple enables access to a series of N-heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about C-C bond cleavage. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Synthetic Route of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hariharan, Palamarneri Sivaraman; Pan, Chengjun; Karthikeyan, Subramanian; Xie, Dexun; Shinohara, Akira; Yang, Chuluo; Wang, Lei; Anthony, Savarimuthu Philip published the artcile< Solvent vapour induced rare single-crystal-to-single-crystal transformation of stimuli-responsive fluorophore: Solid state fluorescence tuning, switching and role of molecular conformation and substituents>, Name: 2-(3,4-Difluorophenyl)acetonitrile, the main research area is solvent vapor crystal transformation fluorescence tuning switching conformation polymorph.

The substituent groups in the aggregation-induced-emissive (AIE) tetraphenylethylene (TPE) based donor (D)-acceptor (A) fluorophores (TPPA-1-6) were tailored. and fluorescent polymorphs formation and single-crystal-to-single-crystal (SC-SC) transition in the solid state was explored. TPPA-1 showed conformational fluorescent polymorphs via twisted and coplanar conformation between TPE Ph group and cyanophenyl acceptor Ph ring. However, single crystal anal. of other derivatives revealed that substituent groups and supramol. interactions control the mol. conformation and SC-SC transition. Fluorophore with same substituent but positional change also show drastic effect on the fluorescent polymorphs formation and SC-SC transition. Substituents that can form strong intermol. interactions stabilize the less stable coplanar structure whereas bulky substituents with weak intermol. interactions produced twisted or both conformers. Photophys., powder x-ray diffraction (PXRD), DSC and thermogravimteric (TG) anal. were performed to substantiate and get insight on the structural transformation. The formation of fluorescent polymorphs and SC-SC transition exhibited tunable and switchable solid state fluorescence. The nonplanar TPE core was made use to demonstrate high contrast stimuli induced reversible fluorescence switching. Overall, the present studies attempted to gain information on the structural design for developing SC-SC transforming functional organic fluorescent materials that could be of potential interests for optoelectronic and display devices.

Dyes and Pigments published new progress about Conformational transition. 658-99-1 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5F2N, Name: 2-(3,4-Difluorophenyl)acetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Peng; Zhuang, Yu-Xin; Diao, Peng-Cheng; Yang, Fang; Wu, Shao-Yu; Lv, Lin; You, Wen-Wei; Zhao, Pei-Liang published the artcile< Synthesis, biological evaluation, and molecular docking investigation of 3-amidoindoles as potent tubulin polymerization inhibitors>, Synthetic Route of 38487-85-3, the main research area is amidoindole preparation antiproliferative mol docking tubulin inhibitor human; 3-Amidoindoles; Antiproliferative activity; Microtubules; Tubulin polymerization.

A series of novel 3-amidoindole derivatives possessing 3,4,5-trimethoxylphenyl groups I [R1 = H, Me, Cl, OMe; R2 = 2-thienyl, Ph, 4-FC6H4, etc.] was synthesized and evaluated for their antiproliferative and tubulin polymerization inhibitory activities. Some of them demonstrated moderate to potent activities in vitro against six cancer cell lines including MCF-7, MDA-MB-231, BT549, T47D, MDA-MB-468, and HS578T. The most active compound I [R1 = Cl; R2 = 4-ClC6H4] inhibited the growth of T47D, BT549, and MDA-MB-231 cell lines with IC50 values at 0.04, 3.17, and 6.43 μM, resp. Moreover, the flow cytometric anal. clearly revealed that compound I [R1 = Cl; R2 = 4-ClC6H4] significantly inhibited growth of breast cancer cells through arresting cell cycle in G2/M phase via a concentration-dependent manner. In addition, the compound I [R1 = Cl; R2 = 4-ClC6H4] also exhibited the most potent anti-tubulin activity with IC50 values of 9.5 μM, which was remarkable, compared to CA-4. Furthermore, mol. docking anal. demonstrated the interaction of the compound I [R1 = Cl; R2 = 4-ClC6H4] at the colchicine-binding site of tubulin.

European Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Synthetic Route of 38487-85-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kotani, Shunsuke; Sakamoto, Midori; Osakama, Kazuki; Nakajima, Makoto published the artcile< A Sterically Congested α-Cyanoamine as a Cyanating Reagent: Cyanation of Acetals and Orthoesters>, Formula: C6H11NO2, the main research area is alkoxy alkanenitrile nitrile cyanation.

The cyanation of acetals and ortho-esters by using a sterically congested α-cyanoamine as a cyanation reagent was investigated. The α-cyanoamine effectively facilitated cyanation in the presence of trichlorosilyl triflate to produce a variety of cyanated adducts in excellent yields. Anal. of the reaction mixture by 1H NMR spectroscopy revealed that trichlorosilyl triflate produced an oxocarbenium cation species as an intermediate. Under optimized conditions the synthesis of the target compounds was achieved using 1,1,1-trifluoromethanesulfonic acid trichlorosilyl ester as a reagent and 2-(dicyclohexylamino)acetonitrile (cyanation agent amine-cyanide) and (dimethoxymethyl)benzene (benzaldehyde acetal), (3,3-dimethoxy-1-propen-1-yl)benzene, (dimethoxymethyl)cyclohexane, 1,1′-[(phenylmethylene)bis(oxymethylene)]bis[benzene], 2-phenyl-1,3-dioxolane (cyclic acetal) as starting materials. The title compounds thus formed included α-(methoxy)benzeneacetonitrile derivatives, α-(methoxy)-1-naphthaleneacetonitrile, 2-methoxy-4-phenyl-2-butenenitrile, α-(2-hydroxyethoxy)benzeneacetonitrile. Ortho-ester reactants included (trimethoxymethyl)benzene, 1,1′,1”-[methylidynetris(oxy)]tris[ethane] and 1,1,1-triethoxypentane. Products therefrom included α,α-dimethoxybenzeneacetonitrile.

European Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Formula: C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kuzuya, Masayuki; Noguchi, Akihiro; Okuda, Takachiyo published the artcile< Quantum chemical consideration of substituent effects on tautomeric properties of 2-pyridones-2-pyridinols>, Reference of 89324-17-4, the main research area is tautomerism pyridone pyridinol UV; MO tautomerism pyridone; substituent effect pyridone tautomerism.

The tautomeric properties of 2-pyridones-2-pyridinols exerted by the substituent effect were discussed on the basis of quantum chem. quantities deduced from MO calculations A substituent at the 6-position has the greatest stabilizing effect. The magnitude of this effect was greater on the 2-pyridinol form than on the 2-pyridone form, irresp. of the nature of the substituent. This led to a large predominance of the 2-pyridinol form on the 6-polar-substituted derivatives, to such an extent that it was observed by conventional UV measurements at ambient temperature In the 6-Me derivative, the 2-pyridinol form was not observed by a similar measurement due to the weak substituent effect. The association ability is still an important factor in determining tautomeric equilibrium in a solution, resulting in a strong lability to the mol. environment. The substituent effects on the stabilities of both tautomers were correlated with the N-at. charges and ring structural modifications of the tautomers.

Bulletin of the Chemical Society of Japan published new progress about Electron configuration. 89324-17-4 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H4N2O, Reference of 89324-17-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dulou, Raymond; Savostianoff, Dimitri published the artcile< Synthesis of glyoxal acetals from diethoxyacetonitrile>, Computed Properties of 6136-93-2, the main research area is .

A series of RCOCH(OEt)2 (I) was prepared from (EtO)2CHCN (II) with the corresponding RMgX. II was obtained in 77% yield by ammonolysis of (EtO)2CHCO2Et and subsequent dehydration of the resulting (EtO)2CHCONH2. II (12.9 g.) in 150 cc. dry Et2O added to about 0.2 mol appropriate RMgX in Et2O (1-1.9 mol/kg.), stirred 1 h., kept 12 h. at room temperature, treated with 50 g. NH4Cl in 200 cc. H2O, and acidified with concentrated HCl to pH 2-3 yielded 80-95% corresponding I listed in the table. R, b.p./mm., n20D, d2020, % yield; Et, 98-100°/55, 1.408, 0.929, 80; iso-Pr, 103-4°/45, 1.408, 0.910, 79; Am, 104-7°/9, 1.420, 0.913, 94; C7H15, 126-30°/10-11, 1.426, 0.886, 94; Ph, 135-6°/12, 1.505, 1.040, 80; cyclohexyl, 108-13°/10, 1.448, 0.961, 95;

Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques published new progress about 6136-93-2. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Computed Properties of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts