Month: October 2022

Subaramanian, Murugan; Ramar, Palmurukan M.; Rana, Jagannath; Gupta, Virendra Kumar; Balaraman, Ekambaram published the artcile< Catalytic conversion of ketones to esters via C(O)-C bond cleavage under transition-metal free conditions>, Application In Synthesis of 21667-62-9, the main research area is aryl ester preparation.

The catalytic conversion of ketones to esters ArC(O)OR [Ar = Ph, 2-furyl, 2-thienyl, etc.; R = Me, CN, Ph, etc.] via C(O)-C bond cleavage under transition-metal free conditions was reported. This catalytic process proceeded under solvent-free conditions and offers an easy operational procedure, broad substrate scope with excellent selectivity, and reaction scalability.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Application In Synthesis of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dong, Li-Na; Zhang, Shuai-Zheng; Zhang, Wan-Lu; Dong, Yao; Mo, Li-Ping; Zhang, Zhan-Hui published the artcile< Synthesis, characterization and application of magnetic biochar sulfonic acid as a highly efficient recyclable catalyst for preparation of spiro-pyrazolo[3,4-b]pyridines>, Application In Synthesis of 21667-62-9, the main research area is cobalt iron oxide biochar sulfonic acid magnetization adsorption stability.

A magnetic biochar sulfonic acid was prepared and characterized by fourier IR spectroscopy (FT-IR), powder x-ray diffraction technol., scanning electron microscope, transmission electron microscope and vibrating sample magnetometer techniques. The prepared catalyst exhibited excellent catalytic activity for synthesis of spiro-pyrazolo[3,4-b]pyridine derivatives via one-pot three-component reaction of 1H-pyrazol-5-amine, isatin and 3-oxo-3-phenylpropanenitrile. The catalyst could be readily recovered and reused several times without an obvious decay of catalytic performance.

Research on Chemical Intermediates published new progress about Adsorption. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Application In Synthesis of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hora, J. published the artcile< The synthesis of bis-endo-2-(hydroxymethyl)-5-(4-imidazolylmethyl)bicyclo[2.2.2]octane and the corresponding cyclohexane analog>, Product Details of C6H11NO2, the main research area is bicyclooctane imidazolylmethyl; cyclohexane imidazolylmethyl; imidazole bicyclooctanyl; cyclization aminoacetal.

The imidazolylbicyclooctane I was prepared in 9 steps by cyclization of 3,4-dihydrobenzoic acid with H2C:CHCO2Me and conversion of the II (R = CO2H, R1 = CO2Me) to II (R = tetrahydropyranyl, R1 = CH2Br) which was treated with Mg and (EtO)2CHCN, followed by reduction formylation, cyclization with HCONH2. 3-Oxabicyclononane was treated with MeCOCl and the cis-1-(chloromethyl)-4-(hydroxymethyl)cyclohexane similarly converted to III.

Recueil des Travaux Chimiques des Pays-Bas published new progress about Cyclization. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Product Details of C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cai, Yue-Ming; Zhang, Xin; An, Cui; Yang, Ye-Fei; Liu, Wei; Gao, Wen-Xia; Huang, Xiao-Bo; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue published the artcile< Catalyst-free oxidative N-N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO>, Reference of 38487-85-3, the main research area is benzotriazinone preparation; aminobenzamide coupling; benzothiadiazole preparation; aminothiol N S coupling; triazolopyridine preparation; pyridinyl methanamine coupling.

A catalyst-free method was developed to synthesize 1,2,3-benzotriazinones I [R = H, 6-Cl, 6-Br, etc.] and 1,2,3-benzothiadiazoles II [R1 = H, 6-Cl, 6-Br, etc.] from 2-amino-benzamides and 2-amino thiols. Of particular note was that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines III [R2 = H, Ph, 4-ClC6H4; R3 = H, 7-Me, 7-Br] from pyridin-2-ylmethanamine was reported for the first time. This approach featured no use of catalyst, extremely mild conditions and excellent efficiency.

Organic Chemistry Frontiers published new progress about Amino thiols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Reference of 38487-85-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Melin, Lea; Gesner, Emily; Attwell, Sarah; Kharenko, Olesya A.; van der Horst, Edward H.; Hansen, Henrik C.; Gagnon, Alexandre published the artcile< Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2>, COA of Formula: C8H8N2O, the main research area is LM146 quinazolin synthesis anticancer SAR PB1 bromodomain.

PB1 is a bromodomain-containing protein hypothesized to act as the nucleosome-recognition subunit of the PBAF complex. Although PB1 is a key component of the PBAF chromatin remodeling complex, its exact role has not been elucidated due to the lack of potent and selective inhibitors. Chem. probes that target specific bromodomains within the complex would constitute highly valuable tools to characterize the function and therapeutic pertinence of PB1 and of each of its bromodomains. Here, we report the design and synthesis of lead compound LM146, which displays strong stabilization of the second and fifth bromodomains of PB1 as shown by DSF. LM146 does not interact with bromodomains outside of sub-family VIII and binds to PB1(2), PB1(5), and SMARCA2B with KD values of 110, 61, and 2100 nM, resp., providing a ~34-fold selectivity profile for PB1(5) over SMARCA2.

ACS Omega published new progress about Antitumor agents. 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, COA of Formula: C8H8N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xie, Hao; Xing, Qiaoyan; Shan, Zhifei; Xiao, Fuhong; Deng, Guo-Jun published the artcile< Nickel-Catalyzed Annulation of o-Haloarylamidines with Aryl Acetylenes: Synthesis of Isoquinolone and 1-Aminoisoquinoline Derivatives>, SDS of cas: 21423-84-7, the main research area is isoquinolone aminoisoquinoline benzoimidazoisoquinoline preparation regioselective; haloarylamidine aryl acetylene annulation nickel catalyst.

An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives I (R1 = H, 8-Me, 6-F etc.; R2 = H, 4-Me, 3-Cl, etc.; R3 = H, Me, n-Bu, Ph, COOEt; R4 = Ph, 4-MeC6H4, 3-pyridyl, etc.) via nickel-catalyzed annulation of substituted 2-halobenzamidines with aryl alkynes in the presence of water is described. Benzo[4,5]imidazo[2,1-a]isoquinolines II (R1 = R2 = H; R3 = H, C6H5; R4 = C6H5, 4-FC6H4, 4-MeOC6H4, etc.) were formed as the dominated products when dry DMSO was used as the solvent. Furthermore, when benzyl substituted amidines were used as the substrates, debenzylation reaction occurred to provide various 1-aminoisoquinoline products.

Advanced Synthesis & Catalysis published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, SDS of cas: 21423-84-7.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fare, Fiorenza; Dei Cas, Michele; Arnoldi, Sebastiano; Casagni, Eleonora; Visconti, Giacomo Luca; Parnisari, Giulia; Bolchi, Cristiano; Pallavicini, Marco; Gambaro, Veniero; Roda, Gabriella published the artcile< Determination of Methyldibromoglutaronitrile (MDBGN) in Skin Care Products by Gaschromatography-Mass Spectrometry Employing an Enhanced Matrix Removal (EMR) Lipid Clean-Up>, HPLC of Formula: 6136-93-2, the main research area is methyldibromoglutaronitrile skin care product gas chromatog mass spectrometry.

A new application of QuEChERS extraction followed by EMR-lipid cleanup and GC-MS anal. is proposed for skin care products. Method is applied to determine MDBGN, a preservative frequently used in cosmetic products before being banned for its allergic reactions. New validated procedure consists in extractingcosmetic products with acetonitrile, removing the lipid matrix and then water and solid particles from organic mixture by two dSPE in sequence and, lastly, analyzing extracts in GC-MS. Compared to classic liquid-liquid extraction with chloroform,method has superior features in terms of applicability to cosmetics, ease of use, working times optimization and, above all, reduction of anal. interfering lipidic constituents. Use of EMR-Lipid dSPE system followed by GC-MS anal. allows to trace and quantify a minimal amount of a banned preservative, MDBGN, in so-called “”complex”” matrixes, such as cosmetic creams. This system shows following advantages: much simpler use, as system provides tubes already packaged with clean-up phase, optimization of working times, and noticeable reduction of extraction impurities allowing cleaner extracts to be obtained. A new application of QuEChERS extraction followed by enhanced matrix removal-lipid cleanup and GC-MS anal. is proposed for skin care products. Compared to classic liquid-liquid extraction with chloroform (upper part),method has superior features in terms of applicability to cosmetics, ease of use, working times optimization and, above all, reduction of anal. interfering lipidic constituents .

European Journal of Lipid Science and Technology published new progress about Chamomile. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, HPLC of Formula: 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yan, Yingkun; Li, Min; Liu, Min; Huang, Min; Cao, Lianyi; Li, Wenzhe; Zhang, Xiaomei published the artcile< Sc(OTf)3-Catalyzed Dearomative [3+2] Annulation of 5-Aminoisoxazoles with Quinone Imine Ketals or Quinone Monoacetals>, Reference of 21667-62-9 , the main research area is indoline fused isoxazoline preparation diastereoselective; dihydrobenzofuran fused isoxazoline preparation diastereoselective; aminoisoxazole quinone imine ketal cyclization scandium triflate catalyst; quinone monoacetal aminoisoxazole cyclization scandium triflate catalyst.

Sc(OTf)3-catalyzed dearomative [3+2] annulations of 5-aminoisoxazoles I (R1 = Me, 4-chlorophenyl, thiophen-2-yl, etc.; R2 = Me, Et, 4-bromophenyl, 3-chlorophenyl; R3 = Me, Et) with quinone imine ketals (QIKs) II (R4 = NTs; R5 = H) and quinone monoacetals (QMAs) II (R4 = O; R5 = H, Me, Cl, Br) were reported. A variety of indoline- and 2,3-dihydrobenzofuran-fused isoxazolines III, IV were afforded in moderate to good yields with excellent diastereoselectivities (all cases >20 : 1 dr). This method featured mild reaction conditions, wide substrate scope, and gram-scale synthesis.

European Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Reference of 21667-62-9 .

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Du, Bingnan; Jiang, Xiaoqing; Sun, Peipei published the artcile< Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group>, Recommanded Product: 2-Chloro-4-methylbenzonitrile, the main research area is halosuccinimide ortho halogenation arylnitrile palladium catalyst; nitrile aromatic ortho halogenation halosuccinimide palladium catalyst.

A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature Using cyano as the directing group, the halogenation reaction gave good to excellent yields. E.g., in presence of Pd(OAc)2 and p-toluenesulfonic acid, reaction of PhCN and NIS gave 84% 2-IC6H4CN. The method is compatible for arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available at least the gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.

Journal of Organic Chemistry published new progress about Halogenation catalysts. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Recommanded Product: 2-Chloro-4-methylbenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feng, Jian-Bo; Wu, Xiao-Feng published the artcile< Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions>, Recommanded Product: 3-Chloro-2-fluorobenzonitrile, the main research area is pyridoquinazolinimine preparation; aminopyridine fluorobenzonitrile cyclization nucleophilic aromatic substitution; quinazolinamine preparation; amidine fluorobenzonitrile cyclization nucleophilic aromatic substitution.

A convenient procedure for the synthesis of pyrido[1,2-a]quinazolinimines e.g., I and quinazolinamines e.g., II was developed via cyclization of 2-fluorobenzonitriles with 2-aminopyridines or amidines resp. through SNAr reactions using potassium tert-butoxide as the promoter. Using this methodol., the desired pyrido[1,2-a]quinazolinimines and quinazolinamines were obtained in moderate to good yields under catalyst-free conditions.

Organic & Biomolecular Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Recommanded Product: 3-Chloro-2-fluorobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts