Month: October 2022

Mokhtar, Mohamed; Alghamdi, Khadijah S.; Ahmed, Nesreen S.; Bakhotmah, Dina; Saleh, Tamer S. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021. The article was titled 《Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases》.Name: 3-Oxo-3-phenylpropanenitrile The article contains the following contents:

A new set of 4,6,7,8-tetrahydroquinolin-5(1H)-ones were designed as cytotoxic agents against breast cancer cell line (MCF-7) and synthesized under ultrasonic irradiation using chitosan decorated copper nanoparticles (CS/CuNPs) catalyst. The new compounds , , , and exhibited the most potent cytotoxic activity of IC50 values (0.002 – 0.004μM) comparing to Staurosporine of IC50; 0.005μM. The latter derivatives exhibited a promising safety profile against the normal human WI38 cells of IC50 range 0.0149 – 0.048μM. Furthermore, the most promising cytotoxic compounds , were evaluated as multi-targeting agents against the RTK protein kinases; EGFR, HER-2, PDGFR-β, and VEGFR-2. Compound 4j showed promising inhibitory activity against HER-2 and PDGFR-β of IC50 values 0.17 x 10-3, 0.07 x 10-3μM in comparison with the reference drug sorafenib of IC50; 0.28 x 10-3, 0.13 x 10-3μM, resp. In addition, induced apoptotic effect and cell cycle arrest at G2/M phase preventing the mitotic cycle in MCF-7 cells. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Name: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2008,Rapid Communications in Mass Spectrometry included an article by Barrero-Moreno, Josefa M.; Tirendi, Salvatore; Reniero, Fabiano; Giordano, Giuseppe; Kotzias, Dimitrios. Recommanded Product: 2,3-Diisobutyl-2,3-dimethylsuccinonitrile. The article was titled 《Identification of 2,3-dimethyl-2,3-diisobutyl succinonitrile in laser printer emissions》. The information in the text is summarized as follows:

2,3-Dimethyl-2,3-diisobutyl succinonitrile was identified as the main volatile organic compound (>90%) emitted from laser printers during printing. Experiments were conducted in a large environmental chamber (30 m3) where printers were placed and working to simulate actual office setting conditions. Air, collected on Tenax TA adsorbent cartridges near the printers, was analyzed by thermal desorption gas chromatog.-mass spectrometry. Determined compounds are discussed. Addnl. data obtained by NMR, Fourier transform IR spectroscopy, and liquid chromatog.-tandem mass spectrometry (LC-MS/MS) supported the proposed structure (having no reported Chem. Abstracts Service number), as 2,3-dimethyl-2,3-diisobutyl succinonitrile. This compound is a byproduct of the thermal decomposition of 2,2′-azobis(2,4-di-Me valeronitrile), a com. available free radical polymerization initiator used in polymerization processes during toner manufacturing By headspace GC/MS, 15 toners used in black and white and color printers were examined; 6 contained 2,3-dimethyl-2,3-diisobutyl succinonitrile, which was also detected in processed paper. The experimental process involved the reaction of 2,3-Diisobutyl-2,3-dimethylsuccinonitrile(cas: 80822-82-8Recommanded Product: 2,3-Diisobutyl-2,3-dimethylsuccinonitrile)

2,3-Diisobutyl-2,3-dimethylsuccinonitrile(cas: 80822-82-8) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Recommanded Product: 2,3-Diisobutyl-2,3-dimethylsuccinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Echemendia, Radell; da Silva, Gustavo P.; Kawamura, Meire Y.; de la Torre, Alexander F.; Correa, Arlene G.; Ferreira, Marco A. B.; Rivera, Daniel G.; Paixao, Marcio W.. COA of Formula: C9H7NO. The article was titled 《A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives》. The information in the text is summarized as follows:

A stereoselective multicomponent approach leading to a novel class of pentasubstituted tetrahydropyridines was described. Variation of the components enabled the incorporation of peptide, sugar and steroid moieties to access chimeric derivatives DFT calculations provided insights about the unprecedented high diastereoselectivity of the MCR.3-Oxo-3-phenylpropanenitrile(cas: 614-16-4COA of Formula: C9H7NO) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.COA of Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sethi, Navjot S.; Prasad, Deo N.; Singh, Rajesh K. published their research in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2021. The article was titled 《Synthesis, Anticancer, and Antibacterial Studies of Benzylidene Bearing 5-substituted and 3,5-disubstituted-2,4-Thiazolidinedione Derivatives》.Application of 17201-43-3 The article contains the following contents:

To develop novel compounds having potent anticancer and antibacterial activities. Several studies have proved that benzylidene analogs of clin. 2,4-TZDs, such as troglitazone and ciglitazone, have more potent antiproliferative activity than their parent compounds Literature studies also revealed that the attachment of more heterocyclic rings, containing nitrogen on 5th position of 2,4-TZD, can enhance the antimicrobial activity. Hence, attachment of various moieties on the benzylidene ring may produce safe and effective compounds in the future. The objective of the present study was to synthesize a set of novel benzylidene ring containing 5- and 3-substituted-2,4-thiazolidinedione derivatives and evaluate them for their anticancer and antibacterial activity. The synthesized compounds were characterized by IR, NMR, mass, and elemental studies. The in vitro cytotoxicity studies were performed for human breast cancer (MCF-7) and human lung cancer (A549) cells and HepG2 cell-line and compared to standard drug doxorubicin by MTT assay. Antimicrobial activity of the synthesized 2,4-thiazolidinediones derivatives was carried out using the cup plate method with slight modification. The results obtained showed that TZ-5 and TZ-13 exhibited good antiproliferative activity against A549 cancer cell-line, whereas TZ-10 exhibited moderate antiproliferative activity against HepG2 cell-line when compared to standard drug doxorubicin. TZ-5 also exhibited reasonable activity against the MCF-7 cell-line with doxorubicin as standard TZ-4, TZ-5, TZ-6, TZ-7, and TZ- 16 exhibited remarkable antibacterial activity against Gram pos. and moderate activity against Gram neg. bacteria with the standard drug ciprofloxacin. Attachment of heterocyclic rings containing nitrogen as the hetero atom improves the anticancer and antimicrobial potential. Attachment of electroneg. elements like halogens can also enhance the antimicrobial activity. Further structure modifications may lead to the development of more potent 2,4-TZD leads that can be evaluated for further advanced studies. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Application of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

SDS of cas: 17201-43-3In 2019 ,《Modulating the expression of chirality in a mechanically chiral rotaxane》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Gell, Charles E.; McArdle-Ismaguilov, Timur A.; Evans, Nicholas H.. The article contains the following contents:

The expression of mech. chirality by a hydrogen bond templated rotaxane, as detected by 1H NMR spectroscopy, may be modulated by affecting the co-conformational behavior of the rotaxane through varying solvent or by addition of acid and base. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3SDS of cas: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.SDS of cas: 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《NHC-catalyzed silylative dehydration of primary amides to nitriles at room temperature》 was written by Hota, Pradip Kumar; Maji, Subir; Ahmed, Jasimuddin; Rajendran, N. M.; Mandal, Swadhin K.. Product Details of 2042-37-7 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

In the presence of the abnormal imidazolylidene carbene I, primary amides underwent chemoselective dehydrogenative dehydration reactions with phenylsilane to yield nitriles; the method bypasses the energetically demanding 1,2-siloxane elimination step usually required for metal/silane catalyzed reactions. The mechanism of the was dehydrogenative dehydration studied using DFT calculations of the transition state structures and their free energies and enthalpies on the dehydration pathway; a silane adduct of I was characterized by NMR and evidence for the formation of H2 and of a disiloxane byproduct provided. In the experiment, the researchers used many compounds, for example, 2-Bromobenzonitrile(cas: 2042-37-7Product Details of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Product Details of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. These research results belong to Al-Rashood, Sara T.; Hamed, Ahmed R.; Hassan, Ghada S.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Alharbi, Amal; Al-Sanea, Mohammad M.; Eldehna, Wagdy M.. HPLC of Formula: 614-16-4 The article mentions the following:

In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic compounds Interestingly, no much attention has been paid to develop spirooxindole derivatives with dual antioxidant and anticancer activities. In this context, a series of spirooxindoles 6a-p was examined for their anticancer effect towards HepG2 hepatocellular carcinoma and PC-3 prostate cancer cell lines. Spirooxindole 6a was found to be an efficient anti-proliferative agent towards both HepG2 and PC-3 cells (IC50 = 6.9 and 11.8μM, resp.). Afterwards, spirooxindole 6a was assessed for its apoptosis induction potential in HepG2 cells, where its pro-apoptotic impact was approved via the significant elevation in the Bax/Bcl-2 ratio and the expression levels of caspase-3,. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Eldehna, Wagdy M.; Salem, Rofaida; Elsayed, Zainab M.; Al-Warhi, Tarfah; Knany, Hamada R.; Ayyad, Rezk R.; Traiki, Thamer Bin; Abdulla, Maha-Hamadien; Ahmad, Rehan; Abdel-Aziz, Hatem A.; El-Haggar, Radwan published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021. The article was titled 《Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer》.Application In Synthesis of 4-Cyanobenzyl bromide The article contains the following contents:

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates ( and ) was designed and synthesized. The anticancer activity for compounds (, and ) was measured against NCI-55 human cancer cell lines. Compound was the most efficient, and thus subjected to the five-dose screen where it showed excellent broad activity against almost all tested cancer subpanels. Furthermore, all conjugates ( and ) showed a good anti-proliferative activity towards colorectal cancer SW-620 and HT-29 cell lines, with an excellent inhibitory effect for compounds and (IC50 = 8.7 and 9.4μM (), and 6.5 and 9.8μM for (), resp.). Both compounds displayed selective cytotoxicity with good safety profile. In addition, both compounds provoked apoptosis in a dose dependent manner in SW-620 cells. Also, they significantly inhibited the anti-apoptotic Bcl2 protein expression and increased the cleaved PARP level that resulted in SW-620 cells apoptosis. After reading the article, we found that the author used 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Application In Synthesis of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Novel phthalimide based analogues: Design, synthesis, biological evaluation, and molecular docking studies》 were Othman, Ismail M. M.; Gad-Elkareem, Mohamed A. M.; El-Naggar, Mohamed; Nossier, Eman S.; Amr, Abd El-Galil E.. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. SDS of cas: 614-16-4 The author mentioned the following in the article:

Pyrazolylphthalimide derivative I was synthesized and reacted with different reagents to afford the target imidazopyrazoles II, III, and IV, pyrazolopyrimidines V (R = NH2, R1 = CN, R2 = SMe; R = H, R1 = COPh, R2 = NH2; R = H, R1 = CN, R2 = NH2) and pyrazolotriazines VI (R3 = CN, R4 = NH2; R3 = CO2Et, R4 = Me) containing phthalimide moiety. The prepared compounds were established by different spectral data and elemental analyses. Addnl., all synthesized derivatives were screened for their antibacterial activity against four types of Gram + ve and Gram-ve strains, and for antifungal activity against two fungi micro-organisms by well diffusion method. Moreover, the antiproliferative activity was tested for all compounds against human liver (HepG-2) cell line in comparison with the reference vinblastine. Moreover, drug-likeness and toxicity risk parameters of the newly synthesized compounds were calculated using in-silico studies. The data from structure-activity relationship (SAR) anal. suggested that phthalimide derivative bearing 3-aminopyrazolone moiety, illustrated the best antimicrobial and antitumor activities and might be considered as a lead for further optimization. To investigate the mechanism of the antimicrobial and anticancer activities, enzymic assay and mol. docking studies were carried out on E. coli topoisomerase II DNA gyrase B and VEGFR-2 enzymes. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4SDS of cas: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.SDS of cas: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《De novo approach for the synthesis of water-soluble interlocked and non-interlocked organic cages》 was written by Chakraborty, Debsena; Modak, Ritwik; Howlader, Prodip; Mukherjee, Partha Sarathi. Related Products of 17201-43-3This research focused ontriazine immidazolium water metal free non interlocked organic cage. The article conveys some information:

Research on self-assembled metallosupramol. architectures has bloomed in recent times. Analogous metal-free organic architectures with water solubility are highly challenging. We report here a unique class of triazine based immidazolium water-soluble metal-free interlocked organic cage, which was synthesized in a one-pot reaction without using dynamic covalent chem. and without any chromatog. separation An analogous non-interlocked cage was also successfully achieved by steric control using different positional isomers of the building blocks. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Related Products of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Related Products of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts