Month: October 2022

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Recommanded Product: Methyl 2-cyanoacetate.

Vikram, Venugopalarao;Penumutchu, Srinivasa R.;Vankayala, Raviraj;Thangudu, Suresh;Amperayani, Karteek Rao;Parimi, Umadevi research published 《 Design, synthesis, molecular docking and cytotoxic activity of novel urea derivatives of 2-amino-3-carbomethoxythiophene》, the research content is summarized as follows. An efficient feasible route for the one-pot synthesis of novel series of urea derivatives (2a-2j) from 2-amino-3-carbomethoxythiophene (1) via in situ isocyanate has been developed, and their corresponding anticancer activities were accomplished. The series of urea derivatives were characterized by using ¹H, ¹³C NMR and mass spectroscopic anal. The cytotoxic activities were evaluated against human cervical (HeLa) and human lung (NCI-H23) cancer cell lines. These studies revealed satisfactory activity for some of the compounds, which could potentially serve as lead compounds for drug discovery and development. Furthermore, mol. docking studies supported in identifying the potential binding sites between the urea derivatives and eukaryotic ribonucleotidereductase (RR). High ambiguity driven docking (HADDOCK) modeling was specifically employed to determine the model complex of RR and urea derivatives The proposed model has provided a deep insight into the mol. level interactions of RR-urea model complexes in understanding the exact pharmacophore for designing highly potent RR inhibitors. Overall, the present work has shed light in developing a feasible and robust approach for the synthesis of novel urea derivatives of 2-amino-3-carbomethoxythiophene and identified a part of mol. structure that is responsible for a specific biol. interaction leading to potential anticancer activities. Graphic abstract: We report herein, the exptl. design, synthesis and characterization of a novel series of urea derivatives of 2-amino-3carbomethoxythiophene with pyrimidine amine and benzyl amine analogs as both derivatives which exhibited potential antitumor activity via one pot synthesis and subsequently studied the structure activity relationships (SAR), and anticancer activities. The docking studies identified a part of molecularstructure that is responsible for a specific biol. interaction leading to the destruction of cancer cells.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Recommanded Product: Methyl 2-cyanoacetate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. Formula: C4H5NO2.

Vereshchagin, Anatoly N.;Karpenko, Kirill A.;Elinson, Michail N.;Minaeva, Alexandra P.;Goloveshkin, Alexander S.;Hansford, Karl A.;Egorov, Mikhail P. research published 《 One-pot five-component high diastereoselective synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitriles, dialkyl malonates and ammonium acetate》, the research content is summarized as follows. A novel five-component diastereoselective synthesis of polysubstituted 2-piperidinones is reported. The Knoevenagel condensation-Michael addition-Mannich cascade of two equivalent of aromatic aldehydes, nitriles, dialkyl malonates, and ammonium acetate or aqueous ammonia in alcs. provides convenient access to alkyl (3SR,4RS,6SR)-5,5-dicyano-2-oxo-4,6-diarylpiperidine-3-carboxylates I (Ar = Ph, 2-MeC₆H₄, 3-O₂NC₆H₄, 3-pyridyl, etc., R³ = Me, Et, n-Pr) with three stereocenters in 52-90% or dialkyl (2SR,3RS,4RS,5SR)-2,4-diaryl-3-cyano-6-oxopiperidine-3,5-dicarboxylates II (Ar = Ph, 4-MeOC₆H₄, 2-ClC₆H₄, etc., R², R³ = Me, Et, n-Pr) with four stereocenters in 38-88%. The formation of products was highly stereoselective, with only one diastereomer formed. Ammonium acetate or aqueous ammonia plays a role both as a catalyst and as a nitrogen source. 2,4,6-Triaryl-3,3,5,5-tetracyanopiperidines were obtained as a side products in the reactions with nitro-substituted aldehydes or with Et and Pr cyanoacetates. A series of 14 2-piperidinones and piperidines was assessed for antimicrobial activity against a panel of five bacteria and two fungi; no significant activity was observed Two side piperidines with nitro substituents in aromatic ring possess bacteriostatic action against S. aureus ATCC 43300 and A. baumannii ATCC 19606 at 32 ug/mL.

Formula: C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Name: 4-(2-Bromoacetyl)benzonitrile.

Venugopala, Katharigatta N.;Chandrashekharappa, Sandeep;Tratrat, Christophe;Deb, Pran Kishore;Nagdeve, Rahul D.;Nayak, Susanta K.;Morsy, Mohamed A.;Borah, Pobitra;Mahomoodally, Fawzi M.;Mailavaram, Raghu Prasad;Attimarad, Mahesh;Aldhubiab, Bandar E.;Sreeharsha, Nagaraja;Nair, Anroop B.;Alwassil, Osama I.;Haroun, Michelyne;Mohanlall, Viresh;Shinu, Pottathil;Venugopala, Rashmi;Kandeel, Mahmoud;Nandeshwarappa, Belakatte P.;Ibrahim, Yasmine F. research published 《 Crystallography, molecular modeling and COX-2 inhibition studies on indolizine derivatives》, the research content is summarized as follows. In this study, the design and synthesis of a new series of 7-methoxy indolizines I [R = 4-F, 4-CN, 3-MeO, 4-Br; R¹ = Et, EtO(O)C] as bioisostere indomethacin analogs were carried out and evaluated for COX-2 enzyme inhibition. All the compounds I showed activity in micromolar ranges and the compound I [R = 4-CN, R¹ = EtO(O)C] emerged as a promising COX-2 inhibitor with an IC₅₀ of 5.84μM, as compared to indomethacin (IC₅₀ = 6.84μM). The mol. modeling study of indolizines I indicated that hydrophobic interactions were the major contribution to COX-2 inhibition. The title compound I [R = 4-Br, R¹ = EtO(O)C] was subjected for single-crystal X-ray studies, Hirshfeld surface anal. and energy framework calculations The X-ray diffraction anal. showed that the mol. I [R = 4-Br, R¹ = EtO(O)C] crystallized in the monoclinic crystal system with space group P 2₁/n with a = 12.0497(6)Å, b = 17.8324(10)Å, c = 19.6052(11)Å, α = 90.000°, β = 100.372(1)°, γ = 90.000° and V = 4143.8(4)Å3. In addition, with the help of Crystal Explorer software program using the B3LYP/6-31G(d, p) basis set, the theor. calculation of the interaction and graphical representation of energy value was measured in the form of the energy framework in terms of coulombic, dispersion and total energy.

Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Safety of 4-(2-Bromoacetyl)benzonitrile.

Venugopala, Katharigatta N.;Chandrashekharappa, Sandeep;Deb, Pran Kishore;Tratrat, Christophe;Pillay, Melendhran;Chopra, Deepak;Al-Shar’i, Nizar A.;Hourani, Wafa;Dahabiyeh, Lina A.;Borah, Pobitra;Nagdeve, Rahul D.;Nayak, Susanta K.;Padmashali, Basavaraj;Morsy, Mohamed A.;Aldhubiab, Bandar E.;Attimarad, Mahesh;Nair, Anroop B.;Sreeharsha, Nagaraja;Haroun, Michelyne;Shashikanth, Sheena;Mohanlall, Viresh;Mailavaram, Raghuprasad research published 《 Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme》, the research content is summarized as follows. A series of 1,2,3-trisubstituted indolizines (, and ) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds , , and were active against the H37Rv-MTB strain with min. inhibitory concentration (MIC) ranging from 4 to 32μg/mL, whereas the indolizines with Et ester group at the 4-position of the benzoyl ring also exhibited anti-MDR-MTB activity (MIC = 16-64μg/mL). In silico docking study revealed the enoyl-acyl carrier protein reductase (InhA) and anthranilate phosphoribosyltransferase as potential mol. targets for the indolizines. The X-ray diffraction anal. of the compound was also carried out. Further, a safety study (in silico and in vitro) demonstrated no toxicity for these compounds Thus, the indolizines warrant further development and may represent a novel promising class of InhA inhibitors and multi-targeting agents to combat drug-sensitive and drug-resistant MTB strains.

Safety of 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Electric Literature of 3032-92-6.

Uema, Seiya;Saito, Kodai;Yamada, Tohru research published 《 Silver-Catalyzed Carbon Dioxide Fixation on Alkynylindoles》, the research content is summarized as follows. A silver-catalyzed carbon dioxide fixation reaction into 2-alkynylindole derivatives I [R¹ = cyclohexyl, Ph, thiophen-2-yl, etc.; R² = H, Me; R³ = H, F, OMe, etc.; R⁴ = H, OMe; -R³R⁴– = -OCH₂O-] was developed to afford tricyclic indoles II. Carbon dioxide was selectively fixed on the N atom of the indole, and only 6-endo-dig cyclization proceeded under mild reaction conditions. Carboxylation on C3 of the indole was not observed This method was applicable for a variety of 2-alkynylindoles I, and the corresponding products II were obtained in high yields without the production of side products.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Electric Literature of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Application of C8F4N2.

Ueda, Masahiro;Kimura, Masaki;Miyagawa, Shinobu;Naito, Masaya;Takaya, Hikaru;Tokunaga, Yuji research published 《 Four- and two-armed hetero porphyrin dimers: their specific recognition and self-sorting behaviours》, the research content is summarized as follows. In this study we self-assembled the four-armed porphyrin hetero dimer capsule Cap4, stabilized through amidinium-carboxylate salt bridges, in CH₂Cl₂ and CHCl₃. The dimer capsule Cap4 was kinetically and thermodynamically more stable than the corresponding two-armed dimer Cap2. The number of arms strongly influenced their recognition behavior; guests possessing small aromatic faces (e.g., 1,3,5-trinitrobenzene) preferred residing in the cavity of the two-armed capsule Cap2, rather than in Cap4, both thermodynamically and kinetically; in contrast, large aromatic guests (e.g., 9,10-dibromoanthracene) were encapsulated predominantly by Cap4 because of favorable entropic effects. The number of arms enabled self-sorting behavior of the dimer formation; complexation studies using an equimolar mixture of the four porphyrin constituents of the two capsules revealed the quant. formation of the corresponding dimers Cap2 and Cap4. Furthermore, we examined the specific mol. recognition of Cap2 and Cap4; NMR experiments of mixtures of Cap2 and Cap4 in the presence of favorable guests for Cap2 and Cap4 revealed that these guest mols. were encapsulated selectively by their preferred hosts.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Application of C8F4N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Formula: C9H5N.

Uchikura, Tatsuhiro;Aruga, Kureha;Suzuki, Riku;Akiyama, Takahiko research published 《 Enantioselective Friedel-Crafts Alkylation Reaction of Pyrroles with N-Unprotected Alkynyl Trifluoromethyl Ketimines》, the research content is summarized as follows. Developed herein is an enantioselective Friedel-Crafts alkylation reaction of N-unprotected alkynyl trifluoromethyl ketimines with pyrroles catalyzed by chiral phosphoric acid to furnish chiral primary α-trifluoromethyl-α-(2-pyrrolyl)propargylamines with high enantioselectivity. Transformation of the alkynyl group of the adducts afforded optically active α-trifluoromethylated amines bearing various substituents such as alkyl, alkenyl, enyne, and triazole without loss of optical purity.

Formula: C9H5N, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Related Products of 20099-89-2.

Tunel, Hasan;Er, Mustafa;Alici, Hakan;Onaran, Abdurrahman;Karakurt, Tuncay;Tahtaci, Hakan research published 《 Synthesis, structural characterization, biological activity, and theoretical studies of some novel thioether-bridged 2,6-disubstituted imidazothiadiazole analogues》, the research content is summarized as follows. In this study, thioether-bridged imidazo[2,1-b][1,3,4]thiadiazole derivatives that contained both imidazole and 1,3,4-thiadiazole I [X=Y = F, Cl; R’ = H, F, Cl, etc. ] were synthesized from the reactions of 2-amino-1,3,4-thiadiazole with phenacyl bromide (at yields of 59% to 74%). The structure of the synthesized compounds I was characterized using ¹H NMR, ¹³C NMR, Fourier-transform IR spectroscopy, elemental anal., mass spectroscopy, and X-ray diffraction anal. Mycelial growth, mycelial growth inhibition, min. inhibitory concentration, min. fungicidal concentration, and LD values against various plant pathogenic fungi were determined for all of the target compounds I synthesized in the study. The test results showed that most of the compounds I had moderate to good antifungal activity. In addition, the absorption, distribution, metabolism, excretion (ADME) parameters of the compounds I were calculated, and it was observed that all of the compounds met the drug-likeness rules in general. Finally, using docking simulations, it was found that compounds I [X=Y = Cl; R’ = Ph, 2-naphthyl] and [X=Y = F; R’ = Ph, 2-naphthyl] showed high affinity to PDB ID:5TZ1, which is an CYP51 antifungal target structure.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Related Products of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. SDS of cas: 31643-49-9.

Tundidor-Camba, Alain;Tagle, Luis H.;Terraza, Claudio A.;Rivera, Jorge;Coll, Deysma;Ortiz, Pablo A. research published 《 Tri-functional oligomeric polyesters prepared from new dicarboxylic acids containing several amino acids residues by Higashi methodology: synthesis, characterization, and study of solubility and thermal behavior》, the research content is summarized as follows. Abstract: The synthesis of polyfunctional aliphatic oligomeric polyesters (poly(ether-imido-esters); PEIEs) containing several amino acid residues is described, and their thermal properties and solubility behavior were studied. The new sym. monomeric dicarboxylic acids were synthesized using 4-nitrophthalonitrile as starting material, which reacted with bisphenol-A or bis(4-hydroxyphenyl)diphenylmethane. Then, the tetranitrile derivatives were hydrolyzed to the tetracarboxylic acids and dehydrated to the resp. dianhydrides. Finally, these compounds reacted with the amino acids glycine or L-alanine to obtain the aliphatic dicarboxylic acid monomers. PEIEs were obtained by Higashi methodol. from these monomers and bisphenol-A, characterized by elemental anal., NMR and IR, and the results were in agreement with the structures. The materials were soluble at 25°C in several aprotic polar organic solvents and some in CHCl₃ and THF. In agreement with the viscosity and SEC results, PEIEs were oligomers with d.p. of four and six, and Mw and Mn between 7370-9790 g/mol and 3680-4850 g/mol, resp. The samples showed low T_g values (124-160°C), associated with important structural flexibility promotes by dicarboxylic acid monomers. Despite this, this parameter depended of the aminoacidic residue nature in the sense that when the volume of it increased, the T_g also increased due to a decrease in the free rotation that neg. affects the segmental movements of the chains. This effect was also observed when the side groups of the diphenol moiety of the dicarboxylic acid monomers increase from Me to Ph. The recorded TDT_10% values from the TGA anal. (334-457°C) do not allow to consider these samples as thermoset materials. In this sense, it was possible to observe an average increase of 8-13°C and 23-28°C when the lateral group volume of the amino acid residues and of the diphenol moiety are increased, resp.

SDS of cas: 31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Computed Properties of 1835-49-0.

Tu, Poyi;He, Xunming;Abu-Reziq, Raed;Pan, Chunyue;Tang, Juntao;Yu, Guipeng research published 《 Fluorinated covalent triazine frameworks for effective CH₄ separation and iodine vapor uptake》, the research content is summarized as follows. In this article, analogous covalent triazine framework (CTFs) were simply prepared through the trimerization of different nitrile building blocks (tetrafluoroterephthalonitrile or terephthalonitrile) under typical ionothermal conditions. We demonstrated that the fluorine contents could be simply altered by changing the comonomer compositions Introducing fluorine could adjust the pore size distribution and electron structure of the network effectively. By increasing fluorine contents, an enhanced CO₂/CH₄ selectivity up to 15.5 was presented. Addnl., electron-concentrated fluorine strengthened CH/π interactions between the polymeric matrixes and guest CH₄, offering a CH₄/N₂ selectivity up to 8.0. The obtained CTFs also exhibited noticeable iodine adsorption capacity in vapor phase (302 wt%) due to their abundance of heteroatoms and porosity. These results clearly demonstrated the promising aspect of introducing fluorine groups into the porous networks for developing efficient sorbent towards potential applications in separating methane gas or iodine vapors and also affording further insight into the development of high performance functional polymers.

Computed Properties of 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts