Shaw, Ranjay team published research in Asian Journal of Organic Chemistry in 2022 | 105-34-0

Recommanded Product: Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: Methyl 2-cyanoacetate.

Shaw, Ranjay;Pratap, Ramendra research published 《 A Green and Base-Free Arylation of Thiomethylated 2-pyranones and Ketene Dithioacetals via Liebeskind-Srogl Coupling in Water》, the research content is summarized as follows. A green and base-free desulfitative coupling of different thioethers I (X = CN, COOMe; Ar1 = 4-methoxyphenyl, 4-fluorophenyl, thiophen-2-yl;) with aryl boronic acids Ar2B(OH)2 (Ar2 = Ph, naphthalen-2-yl, thiophen-3-yl, etc.) to botain II in water was described. Various thiomethylated 2H-pyran-2-ones I (X = CN, COOMe), 2-oxobenzo[h]chromones II and α-aroyl ketene-dithioacetals R2CH(O)CH=C(SCH3)2 (R2 = Ph, naphthalen-2-yl, thiophen-2-yl, etc.) were used as substrate to obtained arylated product I, II in very good to excellent yield. Further utility of reaction was carried out by a one-pot arylation followed by amination of α-aroyl ketene dithioacetals for the synthesis of 1-(4-bromophenyl)-3-morpholino-3-phenylprop-2-en-1-one and diarylazoles III (R3 = Ph, 4-methoxyphenyl, furan-2-yl, etc.; R4 = Ph, thiophen-3-yl, etc.; X = NH, O). The structure of isolated product 2-Oxo-4-phenyl-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile and (Z)-1-(4-Bromophenyl)-3-(methylthio)-3-phenylprop-2-en-1-one was ascertained by spectroscopic and single crystal X-ray diffraction analyses.

Recommanded Product: Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Neha team published research in Chemistry – A European Journal in 2021 | 105-34-0

Category: nitriles-buliding-blocks, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Sharma, Neha;Kumar, Sunil;Battula, Venugopala R.;Kumari, Anu;Giri, Arkaprabha;Patra, Abhijit;Kailasam, Kamalakannan research published 《 A Tailored Heptazine-Based Porous Polymeric Network as a Versatile Heterogeneous (Photo)catalyst》, the research content is summarized as follows. A heptazine-based microporous polymeric network, HMP-TAPA was synthesized by direct coupling of trichloroheptazine and tris(4-aminophenyl)amine (TAPA). A high surface area of 424 m2/g was achieved, which is the highest surface area among heptazine-based polymeric networks (HMPs). The tailored electron-donor and -acceptor units in HMP-TAPA give broad visible-light absorption. HMP-TAPA was employed as metal-free photocatalyst for oxidative coupling of amines to imines under visible light irradiation with 98 % selectivity. Furthermore, the surface basicity of HMP-TAPA was used to achieve metal-free heterogeneous base catalysis for Knoevenagel condensation under base-free conditions with >99 % conversion. In addition, HMP-TAPA showed extreme robustness over a wide pH range (1-14). The versatility and flexibility of the current material design is beneficial for understanding its photoactivity and surface basicity so as to design dual active (photo)catalyst materials for specific applications.

Category: nitriles-buliding-blocks, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Deepak team published research in Green Chemistry in 2022 | 3032-92-6

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Product Details of C9H5N

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C9H5N.

Sharma, Deepak;Hussain, Yaseen;Sharma, Manisha;Chauhan, Pankaj research published 《 Electrochemical cascade synthesis of α-thio-substituted masked aldehydes》, the research content is summarized as follows. The recent upsurge in electrosynthesis has provided efficient and sustainable synthetic strategies for procuring valuable mols. and their precursors. In this context, authors have achieved an efficient cascade synthesis of β,β-dialkoxy sulfides under ambient electrochem. conditions. The electrolysis of terminal aryl alkynes, aromatic and aliphatic thiols, and alcs. initiates a cascade sequence involving the thiol-yne reaction/1,2-thio migration via nucleophilic attack of alkoxides to provide α-thio-substituted masked aldehydes in good yields for a diverse range of substrates. The cascade sequence also works well when using acetic acid and acetic anhydride instead of alcs.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Product Details of C9H5N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shao, Chukai team published research in Asian Journal of Organic Chemistry in 2022 | 3032-92-6

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Computed Properties of 3032-92-6

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Computed Properties of 3032-92-6.

Shao, Chukai;He, Ying;Yin, Hongquan;Chen, Fu-Xue research published 《 Me3SiCl-Catalyzed Electrophilic Thiocyanation/Cyclization of Alkynylbenzoates to Synthesize 4-Thiocyanatoisocourmarins》, the research content is summarized as follows. A metal-free and regioselective electrophilic thiocyanation/cyclization of alkynylbenzoates was developed to afford series of thiocyanato-containing isocourmarins catalyzed by Me3SiCl. Tandem thiocyanation/6-endo cyclization of alkynylbenzoates was achieved using N-thiocyanatosuccinimide (NTS). A wide scope of substrates and functional groups was tolerated with moderate to excellent yield up to 98%. The mild reaction conditions made this protocol more practical to access isocourmarins bearing a thiocyanato group with diversed transformations.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Computed Properties of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shanmugam, Kotteswaran team published research in Journal of Solid State Electrochemistry in 2021 | 105-34-0

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Quality Control of 105-34-0

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. Quality Control of 105-34-0.

Shanmugam, Kotteswaran;Sundaramoorthy, Kannadhasan;Perumalsamy, Ramasamy research published 《 The novel approach of stability aspect in organic oligoene dye for dye-sensitized solar cell applications》, the research content is summarized as follows. The phenyl-conjugated oligoene dye 2-cyano3-(4-diphenylaminophenyl)prop-2-enoic acid (SKS) was synthesized by chem. method, and its structure was confirmed by 1H NMR and 13C NMR anal. Solar cell was made using TiO2 (P-25) as photoanode, synthesized oligoene SKS dye as sensitizer, I/I3- as electrolyte, and platinum as counter electrode. The overall power conversion efficiency of SKS dye based solar cell was 1.76%. The functional groups were identified from the FTIR spectrum. The optical, electrochem., and thermal properties were analyzed. The photostability of SKS dye was analyzed before and after various light irradiation by UV-Vis NIR absorption spectrum.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Quality Control of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shang, Zhi-Hao team published research in Advanced Synthesis & Catalysis in 2021 | 105-34-0

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. SDS of cas: 105-34-0.

Shang, Zhi-Hao;Zhang, Zhen-Xiao;Weng, Wei-Zhao;Wang, Yu-Fei;Cheng, Tian-Wei;Zhang, Qiu-Yi;Song, Li-Qun;Shao, Tian-Qi;Liu, Kai-Xuan;Zhu, Yan-Ping research published 《 A Metal- and Azide-free Oxidative Coupling Reaction for the Synthesis of [1,2,3]Triazolo[1,5-a]quinolines and their Application to Construct C-C and C-P Bonds, 2-Cyclopropylquinolines and Imidazo[1,5-a]quinolines》, the research content is summarized as follows. An iodine-promoted one-pot cascade oxidative annulation reaction was developed for the synthesis of [1,2,3]triazolo[1,5-a]quinolines I [R = H, 7-F, 8-Cl, etc.] from Me azaarenes and N-tosylhydrazines. The reaction has a broad substrate scope and could be easily scaled up to gram-scale. 1,2,3-Triazoles were an important skeletal structure for the construction of C-C and C-P bonds, 2-cyclopropylquinolines and imidazo[1,5-a]quinolines, for which different synthetic applications were explored.

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shang, Xiao team published research in Green Chemistry in 2021 | 20099-89-2

Reference of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Reference of 20099-89-2.

Shang, Xiao;Liu, Xuan;Sun, Yujie research published 《 Flexible on-site halogenation paired with hydrogenation using halide electrolysis》, the research content is summarized as follows. Direct electrochem. halogenation has appeared as an appealing approach in synthesizing organic halides in which inexpensive inorganic halide sources are employed and elec. power is the sole driving force. However, the intrinsic characteristics of direct electrochem. halogenation limit its reaction scope. Herein, we report an on-site halogenation strategy utilizing halogen gas produced from halide electrolysis while the halogenation reaction takes place in a reactor spatially isolated from the electrochem. cell. Such a flexible approach is able to successfully halogenate substrates bearing oxidatively labile functionalities, which are challenging for direct electrochem. halogenation. In addition, low-polar organic solvents, redox-active metal catalysts, and variable temperature conditions, inconvenient for direct electrochem. reactions, could be readily employed for our on-site halogenation. Hence, a wide range of substrates including arenes, heteroarenes, alkenes, alkynes, and ketones all exhibit excellent halogenation yields. Moreover, the simultaneously generated H2 at the cathode during halide electrolysis can also be utilized for on-site hydrogenation. Such a strategy of paired halogenation/hydrogenation maximizes the atom economy and energy efficiency of halide electrolysis. Taking advantage of the on-site production of halogen and H2 gases using portable halide electrolysis but not being suffered from electrolyte separation and restricted reaction conditions, our approach of flexible halogenation coupled with hydrogenation enables green and scalable synthesis of organic halides and value-added products.

Reference of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sever, Belgin team published research in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2021 | 20099-89-2

SDS of cas: 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. SDS of cas: 20099-89-2.

Sever, Belgin;Altintop, Mehlika Dilek;Ciftci, Gulsen Akalin;Ozdemir, Ahmet research published 《 A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-Small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into Their Anticancer Potencies》, the research content is summarized as follows. Targeted therapies acting on specific mol. targets in cancer cells with better curative efficacy and lower toxicity have come into prominence for the management of nonsmall cell lung cancer (NSCLC) and colorectal cancer (CRC). COX-2 stands out as a plausible target for anticancer agents due to its pivotal role in tumor initiation, progression and invasion. Due to the importance of triazolothiadiazine scaffold in targeted anticancer drug discovery, the aim of this work is the design of new triazolothiadiazines as potential anticancer agents for the targeted therapy of NSCLC and CRC. New triazolo[3,4-b]-1,3,4-thiadiazines (2a-g) were synthesized via the ring closure reactions of 2-bromo-1-arylethanones with 4-amino-5-((5-methoxy-2-methyl-1H-indol-3-yl)methyl)-2,4- dihydro-3H-1,2,4-triazole-3-thione (1), which was obtained via the solvent-free reaction of 5- methoxy-2-methyl-3-indoleacetic acid with thiocarbohydrazide. MTT assay was performed to determine their cytotoxic effects on A549 human lung adenocarcinoma, Caco-2 human colorectal adenocarcinoma and CCD-19Lu human lung fibroblast cells. The most potent compounds were evaluated for their effects on apoptosis, caspase-3, mitochondrial membrane potential, cell cycle, ultrastructural morphol. changes and COX-2 in A549 and Caco-2 cells. In silico docking and Absorption, Distribution, Metabolism and Excretion (ADME) studies were also performed using Schrodinger′s Maestro mol. modeling package. 6-(4-Chlorophenyl)-3-[(5-methoxy-2-methyl-1H-indol-3-yl)methyl]-7H-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazine (2e) was the most potent and selective anticancer agent in this series against A549 and Caco-2 cell lines. Compound 2e induced early apoptosis, caused mitochondrial membrane depolarization and arrested cell cycle at G0/G1 phase in A549 cells. On the other hand, compound 2e triggered intrinsic apoptotic pathway involving caspase-3 activation in Caco-2 cells. Compound 2e caused apoptotic morphol. changes in both cancer cell lines. The cytotoxic and apoptotic effects of this compound on CRC were found to be related to its selective COX-2 inhibitory activity. According to mol. docking studies, compound 2e showed good affinity to the active site of COX-2 (PDB code: 4COX). Based on in silico ADME studies, the compound is predicted to possess a favorable ADME profile. According to in vitro and in silico studies, compound 2e was identified as a potential orally bioavailable anticancer agent for COX-2-targeted therapy of CRC.

SDS of cas: 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sever, Belgin team published research in Archiv der Pharmazie (Weinheim, Germany) in 2021 | 20099-89-2

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Formula: C9H6BrNO

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Formula: C9H6BrNO.

Sever, Belgin;Tuerkes, Cueneyt;Altintop, Mehlika D.;Demir, Yeliz;Akalin Ciftci, Guelsen;Beydemir, Suekrue research published 《 Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds》, the research content is summarized as follows. New hybrid thiazolyl-pyrazoline derivatives (4a-k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase (hCA) isoforms I and II as well as on acetylcholinesterase (AChE) were determined All new thiazolyl-pyrazolines showed activity at nanomolar levels as hCA I, hCA II, and AChE inhibitors, with KI values in the range of 13.35-63.79, 7.01-115.80, and 17.89-48.05 nM, resp. 1-[4-(4-Cyanophenyl)thiazol-2-yl]-3-(4-piperidinophenyl)-5-(4-fluorophenyl)-2-pyrazoline (4f) and 1-(4-phenylthiazol-2-yl)-3-(4-piperidinophenyl)-5-(4-fluorophenyl)-2-pyrazoline (4a) against hCAs and 1-[4-(4-chlorophenyl)thiazol-2-yl]-3-(4-piperidinophenyl)-5-(4-fluorophenyl)-2-pyrazoline (4d) and 1-[4-(4-nitrophenyl)thiazol-2-yl]-3-(4-piperidinophenyl)-5-(4-fluorophenyl)-2-pyrazoline (4b) against AChE were identified as highly potent inhibitors, superior to the standard drugs, acetazolamide and tacrine, resp. Compounds 4a-k were also evaluated for their cytotoxic effects on the L929 mouse fibroblast (normal) cell line. Moreover, a comprehensive ligand-receptor interaction prediction was performed using the ADME-Tox, Glide XP, and MM-GBSA modules of the Schrodinger Small-Mol. Drug Discovery Suite to elucidate the potential binding modes of the new hybrid inhibitors against these metabolic enzymes.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Formula: C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sergeev, Pavel G. team published research in European Journal of Organic Chemistry in 2020 | 105-34-0

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Category: nitriles-buliding-blocks

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Sergeev, Pavel G.;Khrustalev, Victor N.;Nenajdenko, Valentine G. research published 《 Synthesis of Pyridazin-3(2H)-one Derivatives by the Reaction of CH-Acids with Dichlorodiazadienes》, the research content is summarized as follows. The reactions of 4,4-dichloro-1,2-diazabuta-1,3-dienes with di-Me malonate, cyanoacetic esters and Et acetoacetate provided straightforward access to highly functionalized pyridazine derivatives The approach was found to be very general for the highly efficient synthesis of various pyridazine derivatives , e.g., I, which can be isolated in moderate to excellent yields. The possibility of their subsequent functionalization was demonstrated. Moreover, the absorption characteristics in the UV/Vis-range and luminescence were studied for all synthesized compounds

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts