Month: October 2022

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Related Products of 20099-89-2.

Liu, Jing;Huang, Hong-Li;Wang, Chen;Li, Yinghua;Li, Huaqiang;Hu, Honggang;He, Shipeng;Tang, Hua;Gao, Fei research published 《 Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives》, the research content is summarized as follows. A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazoles had been established with α-carbonyl alkyl bromides. This protocol provided an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones I [R = CH₂CO₂Et, CH₂C(O)Ph, 4-MeC₆H₄C(O)CH₂, etc.; R¹ = H, Me, Br; R² = H, Me, OMe, t-Bu, F; R³ = H, Me, Br; R⁴ = H, F, Cl, Br; R⁵ = H, Me, Cl; R⁶ = H, Me, Cl] in outstanding yields, mild reaction conditions and excellent functional group tolerance.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Related Products of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. HPLC of Formula: 105-34-0.

Lipin, K. V.;Ershov, O. V. research published 《 Reaction of Disodium Ethene-1,1-bis(thiolates) with Dibromobutanes》, the research content is summarized as follows. 2-(1,3-Dithiolan-2-ylidene)malononitrile, 2-cyano-2-(1,3-dithiolan-2-ylidene)acetamides, and Me 2-cyano-2-(1,3-dithiolan-2-ylidene)acetate were synthesized by reaction of sodium 2-cyanoethene-1,1-bis(thiolates) with dibromobutanes. A one-pot procedure for their synthesis was also developed.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., HPLC of Formula: 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Name: Tetrafluoroterephthalonitrile.

Ling, Honglei;Jin, Jianyong research published 《 Improved synthesis route and performance of azide modified polymers of intrinsic microporosity after thermal self-crosslinking》, the research content is summarized as follows. A new azide modified biscatechol monomer was first obtained and characterized by single-crystal XRD, but its polymerization only afforded a low mol. weight azide-containing polymer of intrinsic microporosity (PIM-N3). The high-mol. PIM-N3 was then obtained via post-modification on PIM-Me, prepared by the fluoride-mediated PIM synthesis method developed by our group in 2015. The crosslinking temperature was set at 220°C based on the thermogravimetric anal. (TGA) data. The thermal self-crosslinking of PIM-N3 significantly enhanced gas permeability. The 6-h crosslinked PIM-N3 (PIM-N3-6 h) exhibited the best combination of CO₂ permeability, and selectivity for CO₂ over N₂ and CH₄, traversing the 2008 Robeson upper bound.

Name: Tetrafluoroterephthalonitrile, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Synthetic Route of 3032-92-6.

Lin, Hui-Shu;Pan, Yong-Zhou;Tian, Yu-Hong;Pan, Ying-Ming;Wang, Xu research published 《 Palladium-Catalyzed Tandem Cyclization of 2-(2 Ethynylphenyl)acetonitriles and Isocyanides: Access to Indeno[2,1-b]pyrroles》, the research content is summarized as follows. A palladium-catalyzed tandem cyclization of 2-(2-ethynylphenyl)acetonitriles I (R¹ = Ph, naphthalen-2-yl, thiophen-3-yl, etc.) with isocyanides CNR² (R² = tert-Bu, cyclohexyl, adamantan-1-yl, etc.) has been developed. Various indeno[2,1-b]pyrroles II were prepared in 55%-82% yields under air atm. at 100°C. The key to the success of this protocol is construction of new C-C and C-N bonds via the orderly insertion of isocyanides.

Synthetic Route of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Electric Literature of 3032-92-6.

Li, Yan;Liu, Deguang;Wan, Lei;Zhang, Jun-Yang;Lu, Xi;Fu, Yao research published 《 Ligand-Controlled Cobalt-Catalyzed Regiodivergent Alkyne Hydroalkylation》, the research content is summarized as follows. Herein, a ligand-controlled cobalt-catalyzed regiodivergent alkyne hydroalkylation was reported. The sensible selection of bisoxazoline and pyridine-oxazoline ligands led to reliable and predictable protocols that provided (E)-1,2-disubstituted and 1,1-disubstituted alkenes with high E/Z stereoselectivity and regioisomeric ratio starting from identical terminal alkyne and alkyl halide substrates and produced trisubstituted alkenes in the case of internal alkynes. This method exhibited a broad scope for terminal and internal alkynes with a wide range of activated and unactivated alkyl halides and shows excellent functional group compatibility.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Electric Literature of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application of C9H6BrNO.

Li, Wangbing;Lu, Zhichao;Hammond, Gerald B.;Xu, Bo research published 《 Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride》, the research content is summarized as follows. An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerated nucleophilic fluorinations using easy handling KF. An inexpensive and com. available ion-exchange resin was successfully converted to the polymer-supported ion pair promoter (A26-SO₄^2-), which could be reused after filtration. Moreover, A26-SO₄^2- could be used in continuous flow conditions. Water was well-tolerated.

Application of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Name: 4-Nitrophthalonitrile.

Li, Siqi;Huang, Zhipeng;Liu, Huifang;Liu, Meijiang;Zhang, Chaofeng;Wang, Feng research published 《 Polar hydrogen species mediated nitroarenes selective reduction to anilines over an [FeMo]S_x catalyst》, the research content is summarized as follows. An efficient approach for the chemoselective synthesis of arylamines RNH₂ (R = 2-fluorophenyl, 2-acetyl-4,5-dimethoxyphenyl, 2-pyridyl, etc.) from nitroarenes RNO₂ and hydrazine over an iron-molybdenum sulfide catalyst ([FeMo]S_x) is presented. The heterogeneous hydrogen transfer reduction can be efficiently carried out at 30°C and provides anilines with 95-99% selectivities. The in situ gas product anal. demonstrates that [FeMo]Sx can catalyze the decomposition of N₂H₄ to H* species, not H₂. Combining with the kinetic anal. of the aniline generation rates from nitrobenzene and intermediates, the nitro group reduction to the nitroso group is confirmed to be the rate-determining step. The pos. slope of Hammett’s equation suggests that the critical intermediate in the rate-determining step is in the neg. state, which suggests that the active H* should be in polar states (H^δ- and H^δ+). These findings will provide a novel route for the synthesis of substituted anilines and broaden the application of MoS_x catalysts under mild conditions.

Name: 4-Nitrophthalonitrile, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Reference of 31643-49-9.

Li, Shuangshuang;Tang, Xinwei;Zhang, Yawei;Lan, Qianqian;Hu, Zhiwei;Li, Le;Zhang, Nan;Ma, Piming;Dong, Weifu;Tjiu, Wengweei;Wang, Zicheng;Liu, Tianxi research published 《 Corrosion-Resistant Graphene-Based Magnetic Composite Foams for Efficient Electromagnetic Absorption》, the research content is summarized as follows. Designing and fabricating high-performance microwave absorption materials with efficient electromagnetic absorption and corrosion resistance becomes a serious and urgent concern. Herein, novel corrosion-resistant graphene-based carbon-coated iron (Fe@C) magnetic composite foam is fabricated via self-assembly of iron phthalocyanine/Fe₃O₄ (FePc hybrid) on the graphene skeletons under solvothermal conditions and then annealing at high temperature As a result, the rational construction of a hierarchical impedance gradient between graphene skeletons and Fe@C particles can facilitate the optimization in impedance matching and attenuation characteristic of the foam, realizing the efficient dissipation for incident electromagnetic waves. Addnl., the performance of electromagnetic absorption can be controllably regulated by optimizing annealing temperature and/or time. More importantly, the formation of a carbon-coated iron structure substantially improves the corrosion resistance of magnetic particles, endowing the composite foam with excellent stability and durability in microwave absorption performance.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Reference of 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Quality Control of 3032-92-6.

Li, Qiuyu;Fang, Xinxin;Pan, Rui;Yao, Hequan;Lin, Aijun research published 《 Palladium-Catalyzed Asymmetric Sequential Hydroamination of 1,3-Enynes: Enantioselective Syntheses of Chiral Imidazolidinones》, the research content is summarized as follows. Pd-catalyzed sequential hydroamination of readily available 1,3-enynes was reported. The redox-neutral process provides an efficient route to synthesize a broad scope of imidazolidinones, thiadiazolidines, and imidazolidines. Asym. sequential hydroamination generates a series of synthetically valuable, enantioenriched imidazolidinones. Mechanistic studies revealed that the transformation occurred via an intermol. enyne hydroamination pathway to give an allene intermediate. Subsequent intramol. hydroamination of the allene intermediate was proceeded under the Curtin-Hammett principle to provide enantioenriched imidazolidinone products.

Quality Control of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Application In Synthesis of 1835-49-0.

Li, Meng;Wu, Mingwei;Pan, Biwei;Xu, Dandan;Lvsong, Zhuopu;Li, Dongqing;Zhang, Fangrong;Huang, Jun research published 《 Aerobic Oxidation of 2,3,6-Trimethylphenol with Reusable Homogenized Copper Catalysts》, the research content is summarized as follows. The oxidation of 2,3,6-trimethylphenol(TMP) can produce both 2,3,5-trimethyl-1,4-benzoquinone(TMQ) and 2,3,5-trimethyl-1,4-hydroquinone(TMHQ) as important intermediates of vitamin E. With a soluble and porous polymer of intrinsic microporosity(PIM-1), we developed a highly active and reusable CuO@PIM-1 catalyst for the aerobic oxidation of TMP to TMQ and TMHQ. The CuO@PIM-1 catalyst is high active and selective for the aerobic oxidation of TMP, and TMQ and TMHQ can be obtained in yields of 81% and 19%, resp. The CuO@PIM-1 catalyst has both advantages of homogeneous and heterogeneous and the CuO@PIM-1 catalyst showed a higher activity than homogeneous(CuCl₂) and heterogeneous(supported CuO) catalysts. Moreover, CuO@PIM-1 catalyst can be recovered easily and reused at least 5 times without deactivation.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Application In Synthesis of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts