Month: October 2022

Sochacka-Cwikla, Aleksandra; Regiec, Andrzej; Zimecki, Michal; Artym, Jolanta; Zaczynska, Ewa; Kocieba, Maja; Kochanowska, Iwona; Bryndal, Iwona; Pyra, Anna; Maczynski, Marcin published an article in 2020, the title of the article was Synthesis and biological activity of new 7-amino-oxazolo[5,4-d]pyrimidine derivatives.Synthetic Route of 5098-14-6 And the article contains the following content:

The synthesis of a series of novel 7-aminooxazolo[5,4-d]pyrimidines I (R = Me, Et, cyclohexyl, etc.), transformations during their synthesis and their physicochem. characteristics have been described. Complete detailed spectral anal. of the intermediates, the N’-cyanooxazolylacetamidine byproducts and final compounds I was carried out using MS, IR, 1D and 2D NMR spectroscopy. Theor. research was carried out to explain the privileged formation of 7-aminooxazolo[5,4-d]pyrimidines in relation to the possibility of their isomer formation and the related thermodn. aspects. Addnl., the single-crystal X-ray diffraction anal. for compound I [R = 2-(morpholin-4-yl)ethyl] was reported. Ten 7-aminooxazolo[5,4-d]pyrimidines I were biol. tested in vitro to preliminarily evaluate their immunol., antiviral and anticancer activity. Compounds I [R = n-pentyl, 3-(N,N-dimethylamino)propyl] showed the best immunoregulatory profile. These compounds displayed low-toxicity and strongly inhibited phytohemagglutinin A-induced proliferation of human peripheral blood lymphocytes and lipopolysaccharide-induced proliferation of mouse splenocytes. Compound I [R = 3-(N,N-dimethylamino)propyl] caused also a moderate suppression of tumor necrosis factor α (TNF-α) production in a human whole blood culture. Of note, the compounds also inhibited the growth of selected tumor cell lines and inhibited replication of human herpes virus type-1 (HHV-1) virus in A-549 cell line. Mol. investigations showed that the compounds exerted differential changes in expression of signaling proteins in Jurkat and WEHI-231 cell lines. The activity of the compound I (R = n-pentyl) is likely associated with elicitation of cell signaling pathways leading to cell apoptosis. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Synthetic Route of 5098-14-6

The Article related to amino oxazolopyrimidine isoxazolyl preparation antitumor antiviral apoptosis, x-ray crystallography, acetamidines, antiviral activity, apoptosis, imidates, immunosuppression, oxazolo[5,4-d]pyrimidines, proliferation, spectral analysis, synthesis and other aspects.Synthetic Route of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cui, Hai-Lei; Peng, Jing; Feng, Xin; Du, Wei; Jiang, Kun; Chen, Ying-Chun published an article in 2009, the title of the article was Dual organocatalysis: asymmetric allylic-allylic alkylation of α,α-dicyanoalkenes and Morita-Baylis-Hillman carbonates.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile And the article contains the following content:

The first highly enantioselective allylic-allylic alkylation of α,α-dicyanoalkenes I (RR1 = 2-C6H4SCH2, 2-C6H4OCH2; R = 2-thienyl, R1 = H; etc) and Morita-Baylis-Hillman carbonates II (R2 = 4-ClC6H4, E = CO2Me; R2 = Ph, E = CN; etc.) by dual catalysis of (DHQD)2AQN and (S)-BINOL was investigated. Excellent stereoselectivities were achieved for a broad spectrum of substrates (d.r. > 99:1, up to 99% ee). The multifunctional allylic products, e.g., III (RR1 = 2-C6H4SCH2, R2 = 4-ClC6H4, E = CO2Me) could be efficiently converted to a range of complex chiral cyclic frameworks. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to cyano alkene asym allylic alkylation carbonate cinchona alkaloid catalyst, diene dinitrile stereoselective preparation intramol michael, asym cyano cyclohexene preparation, cinchona alkaloid binol preparation asym allylic alkylation dual catalysis and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ang, Wei Jie; Chng, Yong Sheng; Lam, Yulin published an article in 2015, the title of the article was Fluorous bispidine: a bifunctional reagent for copper-catalyzed oxidation and Knoevenagel condensation reactions in water.Product Details of 75629-62-8 And the article contains the following content:

Fluorous bispidine-type ligands, I [R = 4-CF3(CF2)7(CH2)3C6H4CH2, (CH2)2(CF2)7CF3] and II [R1 = (CH2)2(CF2)7CF3] has been developed to facilitate its recovery and reusability and to demonstrate its bifunctional property as a ligand and base in copper-catalyzed aerobic oxidation, the Knoevenagel condensation and tandem oxidation/Knoevenagel condensation in water under mild conditions. Application of the fluorous ligand was also extended to the surfactant-free copper-catalyzed allylic and benzylic sp3 C-H oxidation reaction in water. The fluorous ligands could be recovered using F-SPE with recovery ranging from 91-97% and could be reused five times with little loss of activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Product Details of 75629-62-8

The Article related to bispidine fluorous preparation, carbonyl compound preparation green chem, alc aerobic oxidation copper catalyst fluorous bispidine, alkene preparation green chem, active methylene carbonyl compound knoevenagel condensation copper fluorous bispidine and other aspects.Product Details of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 31, 2014, Dyachenko, I. V.; Ramazanova, E. Yu.; Dyachenko, V. D. published an article.Category: nitriles-buliding-blocks The title of the article was Synthesis of 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine-2-thio(seleno)lates and 3-[aryl(hetaryl)]-2-cyanoprop-2-enethioamides by michael reaction. And the article contained the following:

Michael reaction of di-Me (furan-2-ylmethylidene)malonate with 2-cyanoethanethio(seleno)amides and 4-methylmorpholine afforded 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine-2-thio(seleno)lates (I.4-methylmorpholinium; X = S, Se) via exchange of the CH acid components. Aryl(hetaryl)methylidenemalononitriles II reacted with cyanoethanethioamide under analogous conditions to give 3-aryl(hetaryl)-2-cyanoprop-2-enethioamides III which were converted into 3-aryl(hetaryl)-2-(1,3-thiazol-2-yl)prop-2-enenitriles (IV) according to Hantzsch (using BrCH2COR’, R’ = e.g., Ph). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Category: nitriles-buliding-blocks

The Article related to michael carbon acid exchange furanylmethylenemalonate arylmethylenemalononitrile cyanoethanethioamide cyanoethaneselenoamide, pyridinethiolate aminocyanofuranyl, pyridineselenolate aminocyanofuranyl, hantzsch thiazole synthesis arylcyanopropenethioamide and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 31, 1987, Bogdanowicz-Szwed, Krystyna; Feret, Hanna; Lipowska, Malgorzata published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was The reaction of malononitrile with some enamines of 1-indanone. Synthesis of o-aminonitriles of indenopyridine and indenothiopyran. And the article contained the following:

Condensation of indanone enamines I (X = O, R = Ph, C6H4Cl-4) with H2C(CN)2 (II) give indenylidenemalononitriles III in 75 and 80% yields, resp. Cyclization of III with NaOH gave indenopyridones IV (X = O, X1 = NR) in 54 and 80% yields, resp. Condensation of thioamide I (X = S, R= C6H4R1-4, R1 = H, Cl, Br, Me) with II gave indenothiopyrano IV (X = NR, X1 = S) in 64-88% yields. Rearrangement of the thiopyrano gave indenothiopyridones IV (X = S, X1 = NR) in 67-85% yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to indanone enamine condensation malononitrile, indenylidenemalononitrile cyclization hydroxide, indenopyridone aminocyano, indenothiopyran aminocyano rearrangement hydroxide, rearrangement aminocyanoindenothiopyran hydroxide, indenothiopyridone aminocyano and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 12, 1989, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.HPLC of Formula: 34662-29-8 The title of the patent was Preparation of alkanesulfonanilide derivatives as analgesics and inflammation inhibitors. And the patent contained the following:

Title compounds I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxy; R3 = alkyl; R4 = acyl, cyano, HO2C, hydroxyalkyl, HS, alkylthio, alkylsulfinyl, alkylsulfonyl, Q, R7N:CR6, alkanoylalkenyl, (un)substituted 5-membered unsat. heterocyclyl, PhS; R6 = H, H2N, alkyl; R7 = OH, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, H2NCONH, H2NCSNH; R5 = H, halo, alkyl, alkanoyl] and pharmaceutically acceptable salts thereof were prepared I are also useful for treating pyretic diseases, rheumatism, and arthritis. 4′-Amino-3′-(2,4-difluorophenoxy)acetophenone (preparation given) and MeSO2Cl in pyridine were stirred overnight at room temperature to give I (R1 = R5 = H; R2 = 2-F; R3 = Me; R4 = 4-Ac; R8 = 4-F). Similarly prepared was I (R1 = R5 = H; R2 = 2-F; R3 = Me; R4 = 4-cyano; R8 = 4-F) (II). The analgesic activity was demonstrated with II showing an oral ED50 at 2.4 mg/kg in the HOAc-induced writhing test in mice (cf. 1.6 mg/kg for indomethacin). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).HPLC of Formula: 34662-29-8

The Article related to alkanesulfonanilide preparation analgesic antiinflammatory, sulfonanilide alkane preparation analgesic antiinflammatory, antirheumatic alkanesulfonanilide preparation, antipyretic alkanesulfonanilide preparation, antiarthritic alkanesulfonanilide preparation and other aspects.HPLC of Formula: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 20, 2011, Papeo, Gianluca Mariano Enrico; Anatolievna Busel, Alina; Khvat, Alexander; Krasavin, Mikhail Yurievitch; Forte, Barbara; Zuccotto, Fabio published a patent.Quality Control of Methyl 2-cyano-4-fluoro-6-methylbenzoate The title of the patent was Preparation of 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors. And the patent contained the following:

The title compounds I [R = alkyl, alkenyl, alkynyl (each group substituted with one or more substituents selected from either NR3R4, Oalkyl, CO2alkyl and CONRaRb; wherein Ra, Rb = alkenyl, alkynyl, etc.; or NRaRb = (un)substituted heterocyclyl); R1 = H, halo, CN, NO2, etc.; R3, R4 = H, alkenyl, alkynyl, etc.; or NR3R4 = (un)substituted heterocyclyl] which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with respect to poly(ADP-ribose) polymerase PARP-2, and therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation, were prepared and claimed. Thus, reacting 3-oxo-2-(piperidin-4-yl)-2,3-dihydro-1H-isoindole-4-carboxylic acid amide with 4,4-difluorocyclohexanone afforded the amide II. Exemplified compounds I were tested for their activity as PARP inhibitors (data given). The present invention also provides methods for preparing compounds I, pharmaceutical compositions comprising these compounds, and methods of treating, diseases utilizing pharmaceutical compositions comprising these compounds The experimental process involved the reaction of Methyl 2-cyano-4-fluoro-6-methylbenzoate(cas: 877151-43-4).Quality Control of Methyl 2-cyano-4-fluoro-6-methylbenzoate

The Article related to oxoisoindolecarboxamide preparation parp inhibitor combination chemotherapy antitumor cardiovascular, central nervous system injury treatmentoxoisoindolecarboxamide preparation parp inhibitor, antiinflammatory isoindolecarboxamide oxo preparation parp inhibitor and other aspects.Quality Control of Methyl 2-cyano-4-fluoro-6-methylbenzoate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 11, 2007, Wang, Xiang-Shan; Zhang, Mei-Mei; Li, Qing; Yao, Chang-Sheng; Tu, Shu-Jiang published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was An improved and clean procedure for the synthesis of one-donor poly-acceptors systems containing 2,6-dicyanoamine moiety in aqueous media catalyzed by TEBAC in the presence and absence of K2CO3. And the article contained the following:

A clean and simple synthesis of one-donor poly-acceptors systems containing 2,6-dicyanoamine moiety was accomplished via the reaction of 1-arylethylidenemalonodinitriles with arylidenemalonodinitriles in aqueous media catalyzed by TEBAC in the presence of K2CO3. The important intermediates were obtained successfully to confirm the mechanism in the absence of base under the same reaction conditions. The structures of I and II were confirmed by x-ray diffraction studies. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to aminodicyanodihydrophenanthrene preparation, aminoaryltricyanotetrahydrophenanthrene preparation, aminodiarylcyclohexadienetricarbonitrile preparation, arylidenemalonodinitrile dihydronaphthalenylidene malononitrile cycloaddition tebac, tebac cycloaddition catalyst and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 15, 2019, Frasson, Ilaria; Spano, Virginia; Di Martino, Simona; Nadai, Matteo; Doria, Filippo; Parrino, Barbara; Carbone, Anna; Cascioferro, Stella Maria; Diana, Patrizia; Cirrincione, Girolamo; Freccero, Mauro; Barraja, Paola; Richter, Sara N.; Montalbano, Alessandra published an article.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines. And the article contained the following:

[1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low micromolar concentrations (EC50 0.01-6.59 μM). The most photocytotoxic derivative showed very high selectivity and photocytotoxicity indexes (SI = 72-86, PTI>5000), along with a triplet excited state with exceptionally long lifetime (18.0 μs) and high molar absorptivity (29781 ± 180 M-1cm-1 at λmax 315 nm). The light-induced production of ROS promptly induced an unquenchable apoptotic process selectively in tumor cells, with mitochondrial and lysosomal involvement. Altogether, these results demonstrate that the most active compound acts as a promising singlet oxygen sensitizer for biol. applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Name: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to triazolo naphthyridine preparation photocytotoxic activity, oxazolo naphthyridine preparation photocytotoxic activity, photochemiotherapy, photosensitizing agents, reactive oxygen species, [1,2,3]triazolo[4,5-h][1,6]naphthyridines, [1,3]oxazolo[5,4-h][1,6]naphthyridines and other aspects.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 24, 1996, Gazit, Aviv; App, Harald; McMahon, Gerald; Chen, Jefferey; Levitzki, Alexander; Bohmer, Frank D. published an article.HPLC of Formula: 75629-62-8 The title of the article was Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins. And the article contained the following:

A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for inhibition of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The potency of the inhibitors was quinoxalines >quinolines >indoles. Lipophilic groups (Me, methoxy) in the 6 and 7 positions and Ph at the 3 position of quinoxalines and quinolines were essential for potency, in contrast to the hydrophilic catechol group in tyrphostins active against EGFR kinase inhibition at different sites. The inhibitors showed selectivity for PDGF and were not active against EGF receptor and HER-2/c-ErbB-2 receptor. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to quinoxaline tyrosine kinase inhibitor preparation structure, platelet growth factor receptor kinase preparation, quinoline tyrosine kinase inhibitor preparation structure, indole tyrphostin tyrosine kinase inhibitor preparation, msbar tyrosine kinase inhibitor tyrphostin and other aspects.HPLC of Formula: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts