Month: October 2022

On May 1, 2004, Marco, Jose L.; de los Rios, Cristobal; Garcia, Antonio G.; Villarroya, Mercedes; Carreiras, M. Carmo; Martins, Carla; Eleuterio, Ana; Morreale, Antonio; Orozco, M.; Luque, F. Javier published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors. And the article contained the following:

The synthesis and the biol. activity of heterocyclic derivatives as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca2+ channels and nicotinic receptors, are described. These mols. are tacrine analogs, which have been prepared from polyfunctionalized 6-amino-5-cyano-4H-pyrans, 6-amino-5-cyano-pyridines and 5-amino-2-aryl-3-cyano-1,3-oxazoles via Friedlander reaction with selected cycloalkanones. These compounds are moderate acetylcholinesterase and butyrylcholinesterase inhibitors, the BuChE/AChE selectivity of the most active mols. ranges from 10.0 to 76.9. Interestingly, the oxazolo-tacrine’ derivatives are devoid of any activity. All compounds showed an important inhibitory effect on the nicotinic acetylcholine receptor. Most of them also blocked L-type Ca2+ channels, and three of them blocked the non-L type of Ca2+ channels. Mol. modeling studies suggest that these compounds might bind at the peripheral binding site of AChE, which opens the possibility to design inhibitors able to bind at both, the catalytic and peripheral binding sites of the enzyme. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to heterocyclic derivative preparation acetylcholinesterase butyrylcholinesterase inhibitor, calcium channel modulator heterocyclic derivative, nicotinic receptor inhibitor heterocyclic derivative, tacrine analog preparation acetylcholinesterase butyrylcholinesterase inhibitor and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Deshmukh, Mahesh S.; Das, Biswajit; Jain, Nidhi published an article in 2013, the title of the article was Dual SNAr reaction in activated ortho-halonitrobenzene: direct synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines and 1,4-benzodioxines.Recommanded Product: 34662-29-8 And the article contains the following content:

An unprecedented one-pot synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines and 1,4-benzodioxines from activated ortho-halonitrobenzenes was accomplished by dual nucleophilic aromatic substitution (SNAr) of halogen followed by substitution of the nitro group by secondary diamines, secondary amino alcs. and diols resp. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to fluoro nitrobenzene diamine dual aromatic nucleophilic substitution, quinoxaline preparation, aminoalc fluoro nitrobenzene dual aromatic nucleophilic substitution, benzoxazine preparation, diol fluoro nitrobenzene dual aromatic nucleophilic substitution, benzodioxine preparation and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Matsnev, Andrej; Noritake, Shun; Nomura, Yoshinori; Tokunaga, Etsuko; Nakamura, Shuichi; Shibata, Norio published an article in 2010, the title of the article was Efficient Access to Extended Yagupolskii-Umemoto-Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho-Ethynylaryltrifluoromethylsulfanes.Computed Properties of 2510-01-2 And the article contains the following content:

S-(trifluoromethyl)benzo[b]thiophenium salts, as analogs of Yagupolskii-Umemoto type reagents, were synthesized by novel triflic acid mediated intramol. cyclization of ortho-ethynylaryltrifluoromethylsulfanes. Cyclopropyl analog I is especially useful for the electrophilic trifluoromethylation of β-ketoesters and dicyanoalkylidenes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

The Article related to ortho ethynylaryltrifluoromethylsulfane preparation triflic acid intramol cyclization, benzothiophenium salt trifluoromethyl derivative preparation yagupolskii umemoto reagent analog, beta keto ester sulfur trifluoromethyl benzothiophenium salt electrophilic trifluoromethylation and other aspects.Computed Properties of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 1, 2009, Ioannidis, Stephanos; Lamb, Michelle L.; Davies, Audrey M.; Almeida, Lynsie; Su, Mei; Bebernitz, Geraldine; Ye, Minwei; Bell, Kirsten; Alimzhanov, Marat; Zinda, Michael published an article.HPLC of Formula: 5098-14-6 The title of the article was Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors. And the article contained the following:

Pyridineethyl- and pyrimidineethyl-substituted pyrazoleaminopyrazines such as I (R = Me; X = N) and I (R = H; X = CH) are prepared as selective JAK2 kinase inhibitors for potential use as anticancer agents; the GI50 values for their JAK2 and JAK3 kinase inhibition are determined The activities of selected pyridineethyl- and pyrimidineethyl-substituted pyrazoleaminopyrazines in a functional phosphorylation model in mice and their inhibition of aurora B kinase, cyclin-dependent kinase 2, and TrkA are determined; the pharmacokinetics and pharmacodynamics of I (R = Me; X = N) and of I (R = H; X = CH) in rats and beagles are also determined The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).HPLC of Formula: 5098-14-6

The Article related to pyridineethyl pyrimidineethyl pyrazoleaminopyrazine preparation selective jak2 kinase inhibitor, structure pyridineethyl pyrimidineethyl pyrazoleaminopyrazine jak2 kinase inhibition selectivity, pharmacokinetics pharmacodynamics pyrimidineethyl pyrazoleaminopyrazine jak2 kinase inhibitor and other aspects.HPLC of Formula: 5098-14-6

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 15, 2005, Nishiyabu, Ryuhei; Anzenbacher, Pavel Jr. published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Sensing of Antipyretic Carboxylates by Simple Chromogenic Calix[4]pyrroles. And the article contained the following:

A simple, two- or three-step method for the synthesis of chromogenic octamethyl calix[4]pyrrole-based (OMCP) sensors for anions was presented. Electrophilic aromatic substitution allows for converting the pyrrole moieties of OMCP into a dye. The formation of a sensor-anion complex results in partial charge transfer and a dramatic change in color. The absorption (UV-vis) and NMR titration experiments show that the chromogenic OMCPs sense anions administered as aqueous solutions, even at high ionic strength (∼0.1 M NaCl), while displaying selectivity for pyrophosphate and carboxylate anions. The experiments with polyurethane sensor films show a strong response for aqueous carboxylates, such as antipyretics naproxen ≈ ibuprofen > salicylate, without being biased by bicarbonate or carboxy termini of blood plasma proteins. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to antipyretic ibuprofen salicylate naproxen carboxylate chromogenic calixpyrrole preparation, chromogenic calix pyrrole sensor anion preparation, sensor anion complex chromogenic calixpyrrole preparation color change, polyurethane sensor film anion complex chromogenic calixpyrrole color change and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 1, 2005, Geuns-Meyer, Stephanie D.; Hodous, Brian L.; Chaffee, Stuart C.; Tempest, Paul A.; Olivieri, Philip R.; Johnson, Rebecca E.; Albrecht, Brian K.; Patel, Vinod F.; Cee, Victor J.; Kim, Joseph L.; Bellon, Steven; Zhu, Xiaotian; Cheng, Yuan; Xi, Ning; Romero, Karina; Nguyen, Hanh Nho; Deak, Holly L. published a patent.Synthetic Route of 13544-06-4 The title of the patent was Preparation of nitrogen-heteroaryl-containing protein kinase modulators for use against cancer and other diseases. And the patent contained the following:

The present invention relates to nitrogen-heteroaryl-containing compounds (shown as I; variables defined below; e.g. 4-fluoro-3-[[3-(pyrimidin-4-yl)pyridin-2-yl]amino]-N-[3-[(tetrahydrofuran-2-yl)methoxy]-5-trifluoromethylphenyl]benzamide (shown as II)) and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases. For I: A is N or CR10; B is N or CR11; D is N or CR12; E is N or CH; G is NR13, O, S, C(O), S(O), SO2, CR13R13 or CR13R14; H1 is N or CR5; H2 is N or CR6; H3 is N or CR7; H4 is N or CR5; H5 is N or CR9; R1 is H, halo, haloalkyl, NO2, CN, NR13R13, OR13, SR13 (CHR13)nR13, or R15; alternatively R1 taken together with R10 forms a partially or fully unsaturated 5- or 6-membered ring of C atoms optionally including 1-3 heteroatoms = O, N and S, and the ring (un)substituted; R2 is H, halo, haloalkyl, oxo, NO2, CN, SR13, et al.; each of R3 and R4, independently, is H, halo, haloalkyl, oxo, NO2, CN, SR13, et al.; addnl. details including provisos are given in the claims. Although the methods of preparation are not claimed, preparations and/or characterization data for >1200 examples of I and intermediates are included. For example, II was prepared in 2 steps starting with condensation of 4-(2-chloropyridin-3-yl)pyrimidine (preparation given) with 3-amino-4-fluorobenzoic acid in Et3N-TFA to give 4-fluoro-3-[[3-(pyrimidin-4-yl)pyridin-2-yl]amino]benzoic acid, which was condensed with [3-[(tetrahydrofuran-2-yl)methoxy]-5-trifluoromethylphenyl]amine using EDC and DMAP in DMF. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Synthetic Route of 13544-06-4

The Article related to nitrogen heteroaryl containing protein kinase modulator antitumor antiinflammatory, aurora kinase modulator nitrogen heteroaromatic compound preparation, cmet tyrosine kinase modulator nitrogen heteroaromatic compound preparation, braf kinase modulator nitrogen heteroaromatic compound preparation and other aspects.Synthetic Route of 13544-06-4

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Nitrile – Wikipedia,
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On February 21, 2007, Liu, Tian-Yu; Cui, Hai-Lei; Long, Jun; Li, Bang-Jing; Wu, Yong; Ding, Li-Sheng; Chen, Ying-Chun published an article.Application of 2510-01-2 The title of the article was Organocatalytic and Highly Stereoselective Direct Vinylogous Mannich Reaction. And the article contained the following:

The first direct asym. vinylogous Mannich (AVM) reaction of α,α-dicyanoolefins and N-Boc aldimines was described promoted by a simple chiral bifunctional thiourea-tertiary amine organocatalyst. The reaction was highly efficient (S/C up to 1000) and regio-, stereoselective (generally >99% de, >96% ee) at room temperature for a broad array of substrates. Enantiomerically pure δ-amino acid and subsequential δ-lactam could be smoothly prepared from the adduct. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to dicyanoolefin aldimine chiral thiourea tertiary amine asym vinylogous mannich, dicyanovinyl amine stereoselective preparation reduction hydrolysis, amino acid stereoselective preparation amidation, lactam stereoselective preparation, asym vinylogous mannich catalyst chiral thiourea tertiary amine and other aspects.Application of 2510-01-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 24, 2020, Zhuo, Jun-Rui; Quan, Bao-Xue; Zhao, Jian-Qiang; Zhang, Ming-Liang; Chen, Yong-Zheng; Zhang, Xiao-Mei; Yuan, Wei-Cheng published an article.SDS of cas: 2510-01-2 The title of the article was Base-mediated [4+2] annulation of electron-deficient nitrobenzoheterocycles and α,α-dicyanoalkenes in water: Facile access to structurally diverse functionalized dibenzoheterocyclic compounds. And the article contained the following:

A base-mediated [4 + 2] annulation of electron-deficient nitrobenzoheterocycles with α,α-dicyanoalkenes for the synthesis of structurally diverse dibenzoheterocyclic compounds was reported. Reaction of 2-nitrobenzofurans/2-nitrobenzothiophenes with α,α-dicyanoalkenes afforded fused-benzofuran-carbonitrile derivatives and fused-benzothiophene-carbonitrile derivatives I [R1 = H, 10-Me, 10-Cl, etc.; R2 = H, 3-Me, 2-OMe, 4-Br, etc.; R3R4 = H, (CH2)2, OCH2, etc.; X = O, S]. Reaction between 3-nitrobenzothiophenes and α,α-dicyanoalkenes was developed to give fused-benzothiophene-carbonitrile derivatives II [R5 = H, 10-Me, 10-F, 10-Cl, 10-Ph; R6R7 = H, (CH2)2, OCH2, etc.]. Synthesis of fused-indole derivatives III [R8 = H, 10-F, 10-Cl, 11-Br; R9 = acetyl, tert-butyloxycarbonyl, tosyl; R10R11 = H, OCH2, (CH2)2, (CH2)3] by reaction of 3-nitroindoles and α,α-dicyanoalkenes was reported. Preparation of polycyclic heteroaromatic compounds IV [R12 = H, 10-OMe, 10-F, etc.] via oxidative dehydrogenation of some of the fused-benzofuran-carbonitrile derivatives I was reported. The reaction proceeded smoothly via a tandem vinylogous Michael addition/cyclization/tautomerization/elimination process in water with cesium carbonate as base, affording a wide range of dibenzofurans, dibenzothiophenes and carbazoles in good to high yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to dibenzoheterocyclic compound green preparation, nitrobenzoheterocycle dicyanoalkene tandem annulation base mediated, polycyclic heteroaromatic compound preparation, fused benzofuran carbonitrile derivative oxidative dehydrogenation, amino phenyl dihydrophenanthrobenzofuran carbonitrile preparation and other aspects.SDS of cas: 2510-01-2

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Nitrile – Wikipedia,
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On May 17, 1985, Hennen, William J.; Hinshaw, Barbara C.; Riley, Timothy A.; Wood, Steven G.; Robins, Roland K. published an article.Formula: C10H11N3O3S The title of the article was Synthesis of 4-substituted 5-amino-2-(β-D-ribofuranosyl)thiazoles and 4-substituted 5-amino-2-(β-D-ribofuranosyl)selenazoles, and their respective conversion into 2-(β-D-ribofuranosyl)thiazolo[5,4-d]pyrimidines and 2-(β-D-ribofuranosyl)selenazolo[5,4-d]pyrimidines. A new synthesis of tiazofurin and selenazofurin. And the article contained the following:

Anhydroallonothioate (I; Z = S) and -selenoate (I; Z = Se), prepared by treatment of anhydroallonimidate (I; Z = NH) with H2S and H2Se, underwent cyclocondensation with H2NCH(CN)2, NCCN(NH2)CONH2, or NCCH(NH2)CO2Et to give C-nucleosides II (X = S, R = NH2, R1 = cyano; X = S, Se, R = NH2, R1 = CONH2; X = S, Se, R = NH2, R1 = CO2Et). II (X = S, R = NH2, R1 = cyano; X = S, Se, R = NH2, R1 = CONH2) were further cyclized with H2NCH:NH or HC(OEt)3 to give thiazolo- and selenazolopyrimidine C-nucleosides, e.g., III (X = S, Se). II (X = S, Se, R = NH2, R1 = CO2Et) were converted in 2 steps into tiazofurin and selenazofurin (II; X = S, Se, R = H, R1 = CONH2), resp. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to aminoribofuranosylthiazole, aminoribofuranosylselanazole, thiazole c nucleoside, selenazole c nucleoside, ribofuranosylthiazolopyrimidine, ribofuranosylselenazolopyrimidine, thiazolopyrimidine ribofuranosyl, selenazolopyrimidine ribofuranosyl, tiazofurin, selenazofurin, nucleoside c thiazole selenazole and other aspects.Formula: C10H11N3O3S

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 18, 2015, Spallarossa, Andrea; Caneva, Chiara; Caviglia, Matteo; Alfei, Silvana; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Brindisi, Margherita; Zisterer, Daniela M.; Bright, Sandra A.; Williams, Clive D.; Crespan, Emmanuele; Maga, Giovanni; Sanna, Giuseppina; Delogu, Ilenia; Collu, Gabriella; Loddo, Roberta published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents. And the article contained the following:

A new series of indole-based analogs were recently identified as potential anticancer agents. The Knoevenagel-type indoles herein presented were prepared via a one-pot condensation of iminium salts with active methylene reagents and were isolated as single geometric isomers. Biol. evaluation in different cell-based assays revealed an antiproliferative activity for some analogs already in the nanomolar range against leukemia, breast and renal cancer cell lines. To explain these effects, the most promising analogs of the series were engaged in further cell-based studies. Compounds I [R1 = R3 = H, R2 = Ph, X = CN, Y = thien-2-yl-(E), SO2Ph-(E); R1 = R3 = H, R2 = Ph, X = C(:O)Me, Y = SO2Ph-(E); R1 = R3 = H, R2 = C6H4OMe-4, X = CN, Y = CN, SO2Ph-(E)] highlighted a pro-apoptotic potential being able to induce apoptosis in HL60, K562 and MCF-7 cell lines in a dose and time-dependent manner. The ability of these compounds to arrest cell cycle at the G2/M phase inspired the immunofluorescence studies which allowed us to identify tubulin as a potential target for compounds (E)-I [R1 = R3 = H, R2 = Ph, X = CN, Y = SO2Ph; R1 = R3 = H, R2 = C6H4OMe-4, X = CN, Y = SO2Ph]. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to unconventional knoevenagel type indole preparation cell based proapoptotic agent, structure activity relationship unconventional knoevenagel type antiproliferative, leukemia proapoptotic agent unconventional knoevenagel type indole, breast cancer proapoptotic agent unconventional knoevenagel type indole and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts