Month: October 2022

In 2019,Organometallics included an article by Ding, Yi; Ma, Xiaoli; Liu, Yashuai; Liu, Wenqing; Yang, Zhi; Roesky, Herbert W.. Synthetic Route of C7H4FN. The article was titled 《Alkylaluminum Complexes as Precatalysts in Hydroboration of Nitriles and Carbodiimides》. The information in the text is summarized as follows:

The metathesis reaction of aluminum(III) dihydride β-diketiminate LAlH2 (1, L = (DippN:CMe)2CH, Ar = 2,6-iPr2C6H3) with BuLi and Bu2Mg, resp., resulted in di-Bu aluminum complex LAlBu2 (2). Meanwhile 1 reacted with MeLi producing di-Me aluminum LAlMe2 (3). Complexes 2 and 3 were characterized by NMR and elemental anal., and 2 was addnl. studied by single-crystal X-ray diffraction. The reported synthesis allows for access of dialkylaluminum complexes from aluminum(III) dihydride compound (1) with excellent yields. The chemoselective double hydroboration of nitriles or single hydroboration of carbodiimides was studied with pinacolborane (HBpin) using LAl(n-Bu)2 (2) as the precatalyst to afford bis(boryl)amines (4a-4m) and N-borylamines (6a-6d) under solvent-free and mild conditions (60 °C). The records show that the catalytic reactions proceed in quant. yields and short time. Moreover, nearly quant. yield of di(boryl)(silyl)amine (5) was obtained, when cyanobenzene was reacted with equal amounts of HBpin and phenylsilane in the presence of precatalyst 2. A comparison of the previously reported hydroboration reactions with nitriles in the literature and our results in the presence of the precatalyst LAl(n-Bu)2 show convincingly the better results of short reaction time, mild reaction conditions, and quant. yields. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Tuning the porosity and photocatalytic performance of triazine-based graphdiyne polymers through polymorphism》 were Schwarz, Dana; Acharjya, Amitava; Ichangi, Arun; Kochergin, Yaroslav S.; Lyu, Pengbo; Opanasenko, Maksym V.; Tarabek, Jan; Vacek Chocholousova, Jana; Vacek, Jaroslav; Schmidt, Johannes; Cejka, Jiri; Nachtigall, Petr; Thomas, Arne; Bojdys, Michael J.. And the article was published in ChemSusChem in 2019. Application of 623-00-7 The author mentioned the following in the article:

Crystalline and amorphous organic materials are an emergent class of heterogeneous photocatalysts for the generation of hydrogen from water, but a direct correlation between their structures and the resulting properties has not been achieved so far. To make a meaningful comparison between structurally different, yet chem. similar porous polymers, two porous polymorphs of a triazine-based graphdiyne (TzG) framework are synthesized by a simple, one-pot homocoupling polymerization reaction using as catalysts CuI for TzGCu and PdII/CuI for TzGPd/Cu. The polymers form through irreversible coupling reactions and give rise to a crystalline (TzGCu) and an amorphous (TzGPd/Cu) polymorph. Notably, the crystalline and amorphous polymorphs are narrow-gap semiconductors with permanent surface areas of 660 m2 g-1 and 392 m2 g-1, resp. Hence, both polymers are ideal heterogeneous photocatalysts for water splitting with some of the highest hydrogen evolution rates reported to date (up to 972 μmol h-1 g-1 with and 276 μmol h-1 g-1 without Pt cocatalyst). Crystalline order is found to improve delocalization, whereas the amorphous polymorph requires a cocatalyst for efficient charge transfer. This will need to be considered in future rational design of polymer catalysts and organic electronics. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Application of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Application of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids》 were Han, Chong; Kelly, Sean M.; Cravillion, Theresa; Savage, Scott J.; Nguyen, Tina; Gosselin, Francis. And the article was published in Tetrahedron in 2019. Category: nitriles-buliding-blocks The author mentioned the following in the article:

An efficient synthesis of PI3K inhibitor GDC-0077, featuring two consecutive Cu-catalyzed C-N coupling reactions, is reported. The described synthetic route involves a chemoselective Ullmann-type coupling of a chiral difluoromethyl-substituted oxazolidinone, a Cu-catalyzed N-arylation of L-alanine with high stereochem. integrity, and a high-yielding final amide bond formation step to produce GDC-0077 in >99.5 area % HPLC purity. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Category: nitriles-buliding-blocks)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Category: nitriles-buliding-blocks It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《A Complementary C-H Functionalization Mode of Benzoylacetonitriles: Computer-Augmented Study of a Regio- and Stereoselective Synthesis of Functionalized Benzofulvenes》 was published in Organic Letters in 2020. These research results belong to Song, Xia; Do Doan, Bao Nguyen; Zhang, Xinying; Lee, Richmond; Fan, Xuesen. Category: nitriles-buliding-blocks The article mentions the following:

A highly regio- and stereoselective synthesis of functionalized benzofulvenes via Rh(III)-catalyzed cascade reactions of benzoyl acetonitrile/methylsulfone/acetate with propargyl alcs. is presented herein. Mechanistic modeling performed with d. functional theory (DFT) calculations suggested that the hydroxyl group and CsOAc played important roles in mediating the 5-membered ring cyclization by forming a very thermodynamically stable Rh(III) intermediate. Another remarkable feature of this transformation is its excellent stereoselectivity in that only E-isomers are obtained. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Peng, Yi; Oestreich, Martin published an article in 2022. The article was titled 《B(C6F5)3-Catalyzed Reductive Denitrogenation of Benzonitrile Derivatives》, and you may find the article in Organic Letters.SDS of cas: 1194-02-1 The information in the text is summarized as follows:

A B(C6F5)3-catalyzed reductive denitrogenation of aromatic nitriles ArCN (Ar = 4-fluorophenyl, phenanthren-9-yl, 1-benzothiophen-5-yl, etc.) is reported, achieving the metal-free transformation of a cyano into a Me group in a single synthetic operation. Tris(phenylsilyl)amine is liberated as the nitrogen-containing byproduct. On the basis of control experiments as well as a NMR spectroscopic anal., SN1-type mechanism involving a trisilylammonium ion as a key intermediate is proposed. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1SDS of cas: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.SDS of cas: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Long, Yang; Zheng, Yanling; Xia, Ying; Qu, Lang; Yang, Yuhe; Xiang, Haifeng; Zhou, Xiangge published an article in 2022. The article was titled 《Nickel-Catalyzed Synthesis of an Aryl Nitrile via Aryl Exchange between an Aromatic Amide and a Simple Nitrile》, and you may find the article in ACS Catalysis.Recommanded Product: 1194-02-1 The information in the text is summarized as follows:

A nickel-catalyzed synthesis of an aryl nitrile via aryl exchange between an aromatic amide and a simple nitrile was developed. By using cheap, easy-to-handle, and low-toxic 4-cyanopyridine as the cyanating source, cyanation of various aromatic amides afforded an assortment of aryl nitriles including bioactive drugs and organic luminescent mols. in good yields. The reaction exhibited wide substrate scope, good functional group tolerance, and unique selectivity that were complementary to traditional methods. Moreover, two key nickel complexes formed by oxidative addition to each substrate are obtained and determined by X-ray crystallog., which gave strong support for the mechanism elucidations. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Recommanded Product: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Kaya, Meltem; Demir, Sevde; Arici, Mursel; Wriedt, Mario; Yesilel, Okan Zafer published an article in Polyhedron. The title of the article was 《Synthesis, characterization, and optical properties of four coordination polymers with 3,5-dicarboxy-1-(4-cyanobenzyl)pyridin-1-ium bromide》.Safety of 4-Cyanobenzyl bromide The author mentioned the following in the article:

Four coordination polymers based on a new 3,5-dicarboxy-1-(4-cyanobenzyl)pyridin-1-ium bromide (H2cbpyBr), formulated as {[Mn(μ-cbpy)2]·2H2O}n (1), {[Co(μ-cbpy)2]·2H2O}n (2), {[Cu(μ-cbpy)2]·H2O}n (3) and {[Zn3(μ-cbpy)6]·6H2O}n (4) were synthesized and characterized by x-ray single-crystal, IR spectroscopy, powder diffraction, and elemental anal. X-ray diffraction anal. revealed that isostructural complexes 1, 2, and 4 displayed 1D structures while complex 3 exhibited 3D coordination polymer with 66-dia topol. In complexes 1, 2, and 4, the adjacent 1D chains were further assembled by π···π and C:N, π interactions into the 3D supramol. framework. Furthermore, optical properties for the compounds were calculated and thermal behaviors of all the complexes were studied at 30-1000°. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Safety of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Safety of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Formula: C9H7NOIn 2020 ,《Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N-Propargyl Enamines》 appeared in Synthesis. The author of the article were Chikayuki, Yuya; Miyashige, Takakane; Yonekawa, Shiori; Kirita, Akiko; Matsuo, Natsuko; Teramoto, Hiroyoshi; Sasaki, Shigeru; Higashiyama, Kimio; Yamauchi, Takayasu. The article conveys some information:

A transition-metal-free synthesis of pyridine derivatives by 6-endo-dig cyclization of N-propargyl enamines was developed. This method is environmentally friendly and is a high atom economy reaction that is easily accessed to provide pyridine derivatives in moderate to good yield by heating N-propargyl enamines in solvent without additives. The total synthesis of onychine was achieved in 51% yield in only two steps by using this method. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2015,Sugiura, Y.; Tachikawa, Y.; Nagasawa, Y.; Tada, N.; Itoh, A. published 《Synthesis of benzoyl cyanide through aerobic photooxidation of benzyl cyanide using carbon tetrabromide as a catalyst》.RSC Advances published the findings.Related Products of 31938-07-5 The information in the text is summarized as follows:

A synthetic method towards benzoyl cyanide through aerobic photooxidation of benzyl cyanide in the presence of carbon tetrabromide under visible light irradiation with fluorescent lamps have been developed. The experimental part of the paper was very detailed, including the reaction process of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Related Products of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Green Chemistry included an article by Liu, Yaxu; He, Shaopo; Quan, Ziyi; Cai, Huizhuo; Zhao, Yang; Wang, Bo. Application of 1194-02-1. The article was titled 《Mild palladium-catalysed highly efficient hydrogenation of CN, C-NO2, and C=O bonds using H2 of 1 atm in H2O》. The information in the text is summarized as follows:

The first example of a mild and high-efficiency protocol enabling a process in water using 1 atm of H2 for the efficient and selective hydrogenation of nitriles RCN [R = CH3(CH2)2, 4-FC6H4, naphthalen-1-yl, etc.], nitro compounds 4-R1C6H4NO2 (R1 = H, F, Cl, Br, OH, Me, MeO, NH2), ketones R2C(O)R3 [R2 = CH3(CH2)2, 3-FC6H4, 2-H3CC6H4, etc.; R3 = Me, CF3] and aldehydes R4CHO [R4 = 4-(H3C)2CHC6H4, 3,4,5-(H3CO)3C6H2, naphthalen-1-yl, etc.], to yield primary amines RCH2NH2, 4-R1C6H4NH2 and alcs. R2CH(OH)CH3, R4CH2OH with satisfactory yields of up to >99% has been presented. Several palladium-based nanoparticle catalysts were prepared from K2PdCl4 and ligands, and one of them was found to be the best and most suitable for the hydrogenation of CN, C-NO2 and C=O bonds. In addition, the catalyst Pd-NPs can be easily recycled and reused without losing their activity and selectivity. A plausible mechanism for the hydrogenation of a CN bond was also proposed, representing the first example that possesses great potential for sustainable industrial purposes. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts