Month: October 2022

HPLC of Formula: 1194-02-1In 2021 ,《Sensitization-initiated electron transfer via upconversion: mechanism and photocatalytic applications》 was published in Chemical Science. The article was written by Glaser, Felix; Kerzig, Christoph; Wenger, Oliver S.. The article contains the following contents:

Sensitization-initiated electron transfer (SenI-ET) describes a recently discovered photoredox strategy that relies on two consecutive light absorption events, triggering a sequence of energy and electron transfer steps. The cumulative energy input from two visible photons gives access to thermodynamically demanding reactions, which would be unattainable by single excitation with visible light. For this reason, SenI-ET has become a very useful strategy in synthetic photochem., but the mechanism has been difficult to clarify due to its complexity. We demonstrate that SenI-ET can operate via sensitized triplet-triplet annihilation upconversion, and we provide the first direct spectroscopic evidence for the catalytically active species. In our system comprised of fac-[Ir(ppy)3] as a light absorber, 2,7-di-tert-butylpyrene as an annihilator, and N,N-dimethylaniline as a sacrificial reductant, all photochem. reaction steps proceed with remarkable rates and efficiencies, and this system is furthermore suitable for photocatalytic aryl dehalogenations, pinacol couplings and detosylation reactions. The insights presented here are relevant for the further rational development of photoredox processes based on multi-photon excitation, and they could have important implications in the greater contexts of synthetic photochem. and solar energy conversion. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.HPLC of Formula: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 31938-07-5In 2000 ,《Histamine H1 receptor ligands part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives》 was published in Farmaco. The article was written by Walczynski, Krzysztof; Guryn, Roman; Zuiderveld, Obbe P.; Zhang, Ming-Qiang; Timmerman, Henk. The article contains the following contents:

New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the Ph ring, showed weak H1-antagonistic activity (pA2: 4.62-5.04) and this activity was completely lost in the case of meta-Me substituents (pA2 < 4). When the phenylamino group was replaced by benzhydryl groups of classic antihistamines, the resulting compounds exhibited slightly improved H1-antagonistic activity (at the meta-position pA2: 6.38-6.15; at the para-position pA2: 6.04-5.87).2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Recommanded Product: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Accessing Aliphatic Amines in C-C Cross-Couplings by Visible Light/Nickel Dual Catalysis》 was written by Dong, Weizhe; Badir, Shorouk O.; Zhang, Xuange; Molander, Gary A.. Recommanded Product: 105942-08-3This research focused ontrimethylsilylmethanamine aryl bromide nickel catalyst regioselective aminoalkylation; aryl methanamine preparation. The article conveys some information:

A general aminoalkylation of aryl halides were developed, overcoming intolerance of free amines in nickel-mediated C-C coupling. This transformation features broad functional group tolerance and high efficiency. Taking advantage of the fast desilylation of α-silylamines upon single-electron transfer (SET) facilitated by carbonate, α-amino radicals were generated regioselectively, which then engage in nickel-mediated C-C coupling. The reaction displays high chemoselectivity for C-C over C-N bond formation. Highly functionalized pharmacophores and peptides were also amenable. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Recommanded Product: 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1403850-00-9On May 1, 2020 ,《Additions of Aldehyde-Derived Radicals and Nucleophilic N-Alkylindoles to Styrenes by Photoredox Catalysis》 appeared in Organic Letters. The author of the article were Lux, Marcel; Klussmann, Martin. The article conveys some information:

The consecutive addition of acyl radicals and N-alkylindole nucleophiles to styrenes was established, as well as some addnl. radical-nucleophile combinations. Both aryl and aliphatic aldehydes give reasonable yields. The reaction proceeds best for α-substituted styrenes, effectively creating a quaternary all-carbon center. Some iridium-based photoredox systems are catalytically active; furthermore, a base is needed in this transformation. Radicals are formed by reductive perester cleavage and hydrogen atom transfer. In addition to this study using 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile, there are many other studies that have used 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Related Products of 1403850-00-9) was used in this study.

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Related Products of 1403850-00-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C13H11NO2On June 3, 2016, Danda, Adithi; Kesava-Reddy, Naredla; Golz, Christopher; Strohmann, Carsten; Kumar, Kamal published an article in Organic Letters. The article was 《Asymmetric Roadmap to Diverse Polycyclic Benzopyrans via Phosphine-Catalyzed Enantioselective [4 + 2]-Annulation Reaction》. The article mentions the following:

The catalytic addition of the amino acid derived bifunctional N-acylaminophosphine to an α-substituted allene ester generated a zwitterionic dipole that engaged the vinylogous ester function of 3-cyanochromones in a [4 + 2] annulation reaction to deliver tetrahydroxanthones embodying three consecutive chiral centers in high yields and with excellent enantioselectivities. The established asym. synthesis further paves the way to two different classes of complex, sp3-rich tetracyclic benzopyrans via efficient cascade reactions. The experimental process involved the reaction of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Computed Properties of C13H11NO2)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Computed Properties of C13H11NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2010,Kienle, Marcel; Knochel, Paul published 《i-PrI Acceleration of Negishi Cross-Coupling Reactions》.Organic Letters published the findings.Name: 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

The Negishi cross-coupling of arylzinc reagents with various bromoanilines is accelerated by the presence of i-PrI (1 equiv) and furnished the expected biaryls within 5-12 min reaction time at 25 °C. Arylzinc reagents can also be cross-coupled under these conditions with a range of aryl bromides bearing an enolizable ester or acidic benzylic protons. In the part of experimental materials, we found many familiar compounds, such as 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Name: 2-(3-Bromophenyl)acetonitrile)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Name: 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chemical Science included an article by Song, Hualong; Rogers, Nicola J.; Allison, Simon J.; Brabec, Viktor; Bridgewater, Hannah; Kostrhunova, Hana; Markova, Lenka; Phillips, Roger M.; Pinder, Emma C.; Shepherd, Samantha L.; Young, Lawrence S.; Zajac, Juraj; Scott, Peter. Electric Literature of C8H6BrN. The article was titled 《Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification》. The information in the text is summarized as follows:

Helicates and related metallofoldamers, synthesized by dynamic self-assembly, represent an area of chem. space inaccessible by traditional organic synthesis, and yet with potential for discovery of new classes of drug. Here we report that water-soluble, optically pure Fe(II)- and even Zn(II)-based triplex metallohelices are an excellent platform for post-assembly click reactions. By these means, the in vitro anticancer activity and most importantly the selectivity of a triplex metallohelix Fe(II) system are dramatically improved. For one compound, a remarkable array of mechanistic and pharmacol. behaviors is discovered: inhibition of Na+/K+ ATPase with potency comparable to the drug ouabain, antimetastatic properties (including inhibition of cell migration, re-adhesion and invasion), cancer stem cell targeting, and finally colonosphere inhibition competitive with the drug salinomycin. In the experimental materials used by the author, we found 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
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The author of 《Formation of Hetero-binuclear Pt(II)-M(II) Complexes Based on (2-(1H-Tetrazol-5-yl)phenyl)diphenylphosphine Oxide for Superior Phosphorescence of Monomers》 were Huang, Juan; Liu, Zhuo; Chen, Hui; Zhang, Hailing; Zhang, Han; Liu, Chunmei; Gao, Qin; Du, Chenxia; Zhang, Bin. And the article was published in Inorganic Chemistry in 2019. Category: nitriles-buliding-blocks The author mentioned the following in the article:

Novel hetero-binuclear platinum complexes (HBC-Pt(II)-M(II), M = Ca(II), Mg(II), Zn(II), and Cd(II)) have been synthesized by the reaction of the corresponding precursors [Pt(ppy)(μ-Cl)]2 with (2-(1H-tetrazol-5-yl)phenyl)diphenylphosphine oxide (TTPPO). The x-ray structures of the complexes show that two ancillary ligands TTPPO in the square-planar Pt(II) moiety act as a quadridentate chelating agent for the other metal center, eventually forming a distorted octahedral configuration. There are no significant π-π interactions and Pt-M metallophilic interactions in the crystal lattice, due to the steric hindrances associated with the rigid octahedral structure together with the bulky TTPPO. Consequently, HBC-Pt-M complexes show monomer emission characteristics with quantum yields up to 59% in powder, suggesting their great potential for practical applications. DFT and TD-DFT calculations on HBC-Pt-Zn reveal that the phosphorescence can be ascribed to intraligand charge transfer (3ILCT) combined with some metal-to-ligand charge transfer (3MLCT) in the Pt(ppy) moiety, which is consistent with the observations from the photophys. investigations. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Category: nitriles-buliding-blocks)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Design and Synthesis of 5-Morpholino-Thiophene-Indole/Oxindole Hybrids as Cytotoxic Agents》 was written by Yadav, Upasana; Sakla, Akash P.; Tokala, Ramya; Nyalam, Sai Teja; Khurana, Amit; Digwal, Chander Singh; Talla, Venu; Godugu, Chandraiah; Shankaraiah, Nagula; Kamal, Ahmed. Application of 17201-43-3 And the article was included in ChemistrySelect in 2020. The article conveys some information:

A series of new 5-morpholino-thiophene-indole/oxindole hybrids (Z)-I (R1 = PhCH2, 4-MeOC6H4CH2, 4-NCC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 4-ClC6H4CH2; R2 = 4-MeOC6H4, 4-MeC6H4, 4-ClC6H4) and (Z)-II (R3 = H, Cl) has been designed and synthesized using mol. hybridization approach. The synthesized compounds I and II were evaluated for their in vitro cytotoxic potential against selected human cancer cell lines such as triple neg. breast (MDA-MB-231), liver (SK-Hep-1), breast (MCF-7), colon (HCT-116) mouse melanoma (B16F10) and compared with normal human lung epithelial cell line (BEAS-2B). Among I and II, I (R1 = PhCH2; R2 = 4-MeC6H4) (III) showed significant cytotoxicity in HCT-116 cancer cells with an IC50 value of 8.98 ± 0.6μM. Cell cycle anal. revealed that selected compounds arrested the cell cycle in sub-G1 phase. Moreover, JC-1, acridine orange, DAPI nucleic acid, and DCFDA staining studies suggest that III inhibited cellular proliferation through induction of apoptosis. Further, mol. docking and relative viscosity studies of III indicated that III bound in the minor groove of calf thymus DNA. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Application of 17201-43-3

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Nitrile – Wikipedia,
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《Design, synthesis and SARs of novel telomerase inhibitors based on BIBR1532》 was written by Liu, Chao; Zhou, Hua; Sheng, Xiao Bao; Liu, Xin Hua; Chen, Fei Hu. SDS of cas: 31938-07-5 And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

Telomerase has become one of the new popular targets for the development of anti-tumor drugs. Based on the structural characteristics of the BIBR1532 which has entered the stage of clin. research, six series total of 64 new compounds with diverse structural characteristics were designed and synthesized. The inhibitory activity against SGC-7901, MGC-803, SMMC-7721, A375 and GES cell lines and their telomerase inhibitory activity were tested. Among them, eight compounds showed good activity against cancer cells, among them compounds 56, 57 and 59 also showed low toxicity. Some of them showed excellent telomerase inhibitory activity with IC50 values ranging from 0.62μM to 8.87μM. Based on above, in depth structure-activity relationships were summarized, the compounds by replacing Me group with cyanide and retaining amide moiety had good anti-tumor activity, moderate cytotoxicity, and better telomerase inhibitory activity. The results should be used for reference in BIBR1532-based structural optimization for further development of small mol. telomerase inhibitors. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.SDS of cas: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts