Month: October 2022

In 2022,Wang, Jianhua; Li, Xiaoxun published an article in Chemical Science. The title of the article was 《Asymmetric β-arylation of cyclopropanols enabled by photoredox and nickel dual catalysis》.Synthetic Route of C7H3BrFN The author mentioned the following in the article:

The enantioselective functionalization and transformation of readily available cyclopropyl compounds are synthetically appealing yet challenging topics in organic synthesis. Here authors report an asym. β-arylation of cyclopropanols with aryl bromides enabled by photoredox and nickel dual catalysis. This dual catalytic transformation features a broad substrate scope and good functional group tolerance at room temperature, providing facile access to a wide array of enantioenriched β-aryl ketones bearing a primary alc. moiety in good yields with satisfactory enantioselectivities (39 examples, up to 83% yield and 90% ee). The synthetic value of this protocol was illustrated by the concise asym. construction of natural product calyxolane B analogs. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Synthetic Route of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Synthetic Route of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Pan, Liuming; Fu, Wenqian; Zhang, Lei; Wang, Siming; Tang, Tiandi published an article in Molecular Catalysis. The title of the article was 《Highly dispersed Co species in N-doped carbon enhanced the aldehydes ammoxidation reaction activity》.Product Details of 1194-02-1 The author mentioned the following in the article:

Natural vitamin B12 was used as a carbon source for the preparation of a cobalt- and nitrogen-doped catalyst precursor, which was pyrolyzed at different temperatures to obtain cobalt- and nitrogen-doped carbon (Co@NC-T) (T denotes pyrolysis temperature) catalysts. The Co@NC-800 exhibited excellent activity and selectivity in the ammoxidation of aromatic aldehydes with ammonium carbonate to aromatic nitriles compared to the Co@NC-700, Co@NC-600 and Co@NC-500 catalysts. The high catalytic performance of Co@NC-800 could be due to the presence of the low-d. electron cloud of the highly dispersed Co species, which could interact with the benzene ring of benzaldehyde bearing p-π conjugate, thereby promoting the adsorption and activation of benzaldehyde. Consequently, the activated benzaldehyde reacted with amino groups that were decomposed from ammonium carbonate and subsequently underwent a dehydration process to form nitriles.4-Fluorobenzonitrile(cas: 1194-02-1Product Details of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Product Details of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Liang, Yu-Jie; Zhu, Bo; Su, Zhong-Min; Guan, Wei published an article in Inorganic Chemistry. The title of the article was 《IrIII/NiII-Metallaphotoredox-Catalyzed Enantioselective Decarboxylative Arylation of α-Amino Acids: Theoretical Insight of Enantio-Determining Outer-Sphere Reductive Elimination》.Synthetic Route of C7H4BrN The author mentioned the following in the article:

The IrIII/NiII-metallaphotoredox-catalyzed enantioselective decarboxylative arylation of α-amino acids has been systematically investigated using d. functional theory calculations The combination of oxidative quenching (IrIII-*IrIII-IrIV-IrIII) or reductive quenching (IrIII-*IrIII-IrII-IrIII) cycle with the nickel catalytic cycle (NiII-NiI-NiIII-NiII) is possible. The favorable reaction mechanism consists of three major processes: single-electron transfer, oxidative addition, and stepwise outer-sphere reductive elimination. The rate-determining step is the oxidative addition Unexpectedly, the enantio-determining C-C bond formation occurs via an ion-pair intermediate involved in the stepwise outer-sphere reductive elimination process, which is unusual in the IrIII/NiII-metallaphotoredox catalysis. Furthermore, computational results reveal that the high enantioselectivity of this reaction is mainly dependent on the steric effect of substituents on substrates. This theor. study provides useful knowledge for deep insights into the activity and selectivity of visible-light-mediated enantioselective metallaphotoredox dual catalysis at the mol. and at. levels and benefits the development of asym. synthesis. In the experimental materials used by the author, we found 4-Bromobenzonitrile(cas: 623-00-7Synthetic Route of C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Synthetic Route of C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Zhao, Rongrong; Wen, Simiaomiao; Fu, Hao; Liu, Mengna; Liu, Qixing; Zhou, Haifeng published an article in Green Chemistry. The title of the article was 《Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen》.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

A simple, efficient and clean approach for the synthesis of diverse dihydroisoquinolino[2,1-a]quinazolinones, 2-aryl quinazolinones and analogs through intramol. acceptorless dehydrogenative coupling has been achieved. The combination of bis(2-methoxyethyl)ether and mol. oxygen was identified as a highly efficient system for this oxidative dehydrogenative coupling sequential transformation without an external initiator, catalyst and additive. The applicability and practicability were demonstrated by a scope of twenty-nine examples and a gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Formula: C7H4BrNIn 2019 ,《Semiheterogeneous Dual Nickel/Photocatalytic (Thio)etherification Using Carbon Nitrides》 was published in Organic Letters. The article was written by Cavedon, Cristian; Madani, Amiera; Seeberger, Peter H.; Pieber, Bartholomaeus. The article contains the following contents:

A carbon nitride material can be combined with homogeneous nickel catalysts for light-mediated cross-couplings of aryl bromides with alcs. under mild conditions. The metal-free heterogeneous semiconductor is fully recyclable and couples a broad range of electron-poor aryl bromides with primary and secondary alcs. as well as water. The application for intramol. reactions and the synthesis of active pharmaceutical ingredients was demonstrated. The catalytic protocol is applicable for the coupling of aryl iodides with thiols as well. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Formula: C7H4BrN) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Formula: C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 4-Bromo-2-fluorobenzonitrileIn 2020 ,《Substrate profiling of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870》 was published in Molecules. The article was written by Mashweu, Adelaide R.; Chhiba-Govindjee, Varsha P.; Bode, Moira L.; Brady, Dean. The article contains the following contents:

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a bi-aryl axis, prepared by the Suzuki coupling reaction, Morita-Baylis-Hillman adducts, heteroatom-linked diarylpyridines prepared by Buchwald-Hartwig cross-coupling reactions and imidazo[1,2-a]pyridines prepared by the Groebke-Blackburn-Bienayme multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the bi-aryl compounds and Morita-Baylis-Hillman products but not the Groebke-Blackburn-Bienayme products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Name: 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Thermochromic aggregation-induced dual phosphorescence via temperature-dependent sp3-linked donor-acceptor electronic coupling》 was written by Wang, Tao; Hu, Zhubin; Nie, Xiancheng; Huang, Linkun; Hui, Miao; Sun, Xiang; Zhang, Guoqing. Application In Synthesis of 4-Cyanobenzyl bromideThis research focused ontriphenylamine phosphorescence aggregation induced emission. The article conveys some information:

Aggregation-induced emission (AIE) has proven to be a viable strategy to achieve highly efficient room temperature phosphorescence (RTP) in bulk by restricting mol. motions. Here, we show that by utilizing triphenylamine (TPA) as an electronic donor that connects to an acceptor via an sp3 linker, six TPA-based AIE-active RTP luminophores were obtained. Distinct dual phosphorescence bands emitting from largely localized donor and acceptor triplet emitting states could be recorded at lowered temperatures; at room temperature, only a merged RTP band is present. Theor. investigations reveal that the two temperature-dependent phosphorescence bands both originate from local/global min. from the lowest triplet excited state (T1). The reported mol. construct serves as an intermediary case between a fully conjugated donor-acceptor system and a donor/acceptor binary mix, which may provide important clues on the design and control of high-freedom mol. systems with complex excited-state dynamics. In the experimental materials used by the author, we found 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Application In Synthesis of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrileOn May 26, 2008, Rashid, Muhammad A.; Rasool, Nasir; Appel, Bettina; Adeel, Muhammad; Karapetyan, Vahuni; Mkrtchyan, Satenik; Reinke, Helmut; Fischer, Christine; Langer, Peter published an article in Tetrahedron. The article was 《Synthesis of 1-azaxanthones by condensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-(cyano)benzopyrylium triflates and subsequent domino retro-Michael/nitrile-addition/heterocyclization’ reaction》. The article mentions the following:

Functionalized 1-azaxanthones (5-oxo-5H-[1]-benzopyrano[2,3-b]pyridines), e.g. I, were prepared by TMSOTf-mediated condensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-cyanochromones and subsequent base-mediated domino retro-Michael/nitrile-addition/heterocyclization reaction.6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile) was used in this study.

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Greiner, Robert; Ziegler, Dorothee S.; Cibu, Denise; Jakowetz, Andreas C.; Auras, Florian; Bein, Thomas; Knochel, Paul published 《Preparation of Polyfunctional Naphthyridines by Cobalt-Catalyzed Cross-Couplings of Halogenated Naphthyridines with Magnesium and Zinc Organometallics》.Organic Letters published the findings.COA of Formula: C7H3BrFN The information in the text is summarized as follows:

CoCl2 (5%) catalyzes cross-couplings of various halogenated naphthyridines with alkyl- and arylmagnesium halides. Also, arylzinc halides undergo smooth cross-couplings with various naphthyridines in the presence of CoCl2·2LiCl (5%) and sodium formate (50%), leading to polyfunctional arylated naphthyridines. Two of these arylated naphthyridines, e. g., I, are highly fluorescent, with quantum efficiencies reaching 95% and long excited-state lifetimes of up to 12 ns. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3COA of Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.COA of Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Tetrahedron Letters included an article by Yu, Xiaoqiang; Yin, Qing; Zhang, Zhiheng; Huang, Tianyu; Pu, Zichao; Bao, Ming. Formula: C7H4FN. The article was titled 《Synthesis of 2-substituted benzothiazoles via the Bronsted acid catalyzed cyclization of 2-amino thiophenols with nitriles》. The information in the text is summarized as follows:

A convenient and efficient method for the synthesis of 2-substituted benzothiazoles I [R1 = H, 5-Cl; R2 = H, 4-Me, 3-F3C, etc.] from simple and readily available 2-aminothiophenols and nitriles was described. The Bronsted acid-catalyzed cyclization reaction was performed under metal and solvent-free conditions. The low cost of catalyst and simplicity of procedure were advantages of this method. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzonitrile(cas: 1194-02-1Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Formula: C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts