Month: October 2022

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Formula: C8F4N2.

Yang, Chongqing;Jiang, Kaiyue;Zheng, Qi;Li, Xinle;Mao, Haiyan;Zhong, Wenkai;Chen, Cheng;Sun, Bing;Zheng, Haimei;Zhuang, Xiaodong;Reimer, Jeffrey A.;Liu, Yi;Zhang, Jian research published 《 Chemically stable polyarylether-based metallophthalocyanine frameworks with high carrier mobilities for capacitive energy storage》, the research content is summarized as follows. Covalent organic frameworks (COFs) with efficient charge transport and exceptional chem. stability are emerging as an import class of semiconducting materials for opto-/electronic devices and energy-related applications. However, the limited synthetic chem. to access such materials and the lack of mechanistic understanding of carrier mobility greatly hinder their practical applications. Herein, we report the synthesis of three chem. stable polyarylether-based metallophthalocyanine COFs (PAE-PcM, M = Cu, Ni, and Co) and facile in situ growth of their thin films on various substrates (i.e., SiO₂/Si, ITO, quartz) under solvothermal conditions. We show that PAE-PcM COFs thin films with van der Waals layered structures exhibit p-type semiconducting properties with the intrinsic mobility up to ~19.4 cm² V^-1 s^-1 and 4 orders of magnitude of increase in conductivity for PAE-PcCu film (0.2 S m^-1) after iodine doping. D. functional theory calculations reveal that the carrier transport in the framework is anisotropic, with the out-of-plane hole transport along columnar stacked phthalocyanine more favorable. Furthermore, PAE-PcCo shows the redox behavior maximumly contributes ~88.5% of its capacitance performance, giving rise to a high surface area normalized capacitance of ~19 μF cm^-2. Overall, this work not only offers fundamental understandings of electronic properties of polyarylether-based 2D COFs but also paves the way for their energy-related applications.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Formula: C8F4N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Recommanded Product: 4-Ethynylbenzonitrile.

Yang, Bin;Yang, Junfeng;Zhang, Junliang research published 《 Synthesis of Axially Chiral Anilides Enabled by a Palladium/ Ming-Phos-Catalyzed Desymmetric Sonogashira Reaction》, the research content is summarized as follows. Atropisomeric anilides are one of important C-N axially chiral compounds Compared with the N-terminal functionalization to prepare such compounds, C-terminal functionalization strategies have been rarely reported. Authors describe herein an efficient synthesis of axially chiral anilides enabled by Pd-catalyzed desym. Sonogashira cross-coupling reactions with the use of a newly identified Ming-Phos. Moderate to high yields with high enantioselectivities (up to 98% ee) were obtained.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Application of C8F4N2.

Yan, Zhi-Ping;Liu, Ting-Ting;Wu, Ruixia;Liang, Xiao;Li, Zhi-Qiang;Zhou, Liang;Zheng, You-Xuan;Zuo, Jing-Lin research published 《 Chiral Thermally Activated Delayed Fluorescence Materials Based on R/S-N²,N²′-Diphenyl-[1,1′-binaphthalene]-2,2′-diamine Donor with Narrow Emission Spectra for Highly Efficient Circularly Polarized Electroluminescence》, the research content is summarized as follows. In this study, two pairs of chiral thermally activated delayed fluorescence (TADF) materials enabling circularly polarized luminescence (CPL) named R/S-p-BAMCN (rod-shape) and R/S-o-BAMCN (helix-shape) are prepared based on a new pair of chiral donor (D*), R/S-N2,N2′-diphenyl-[1,1′-binaphthalene]-2,2′-diamine (R/S-BAM), and two cyano (CN) acceptors. Due to the rigid mol. structure and special intramol. arrangement, the chiral TADF materials show high photoluminescence quantum efficiency (up to 0.86) with narrow full-width at half-maximum (38 nm in cyclohexane, 51 nm in toluene) and photoluminescence dissymmetry factor (|gPL|) up to 5.3 x 10^-3. Particularly, the circularly polarized OLEDs (CP-OLEDs) with rod-shaped R/S-p-BAMCN as the emitter show high device performances with the maximum external quantum efficiency nearing 28%. Meanwhile, the semi-transparent CP-OLEDs based on helix-shaped R/S-o-BAMCN exhibit obvious circularly polarized electroluminescence (CPEL) properties with the electroluminescence |gEL| factors around 4.6 x 10-3. The strategy of rigid D*-A-D* structure with special arrangement of chiral donor provides a direct way to obtain efficient CP-TADF materials with narrow emission spectra and promising CPL properties for better CPEL performance.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Application of C8F4N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Category: nitriles-buliding-blocks.

Yalazan, Halise;Tuezuen, Burak;Akkaya, Didem;Barut, Burak;Kantekin, Halit;Yildirmis, Sermet research published 《 Quinoline-fused both non-peripheral and peripheral Zn^II and Mg^II phthalocyanines: Anti-cholinesterase, anti-glucosidase, DNA nuclease, antioxidant activities, and in silico studies》, the research content is summarized as follows. Quinoline-fused Zn^II (ZnPc^p/ZnPc^np) and Mg^II (MgPc^p/MgPc^np) phthalocyanines with four 4-methylquinolin-2-ol (1) at nonperipheral or peripheral positions of the phthalocyanine core were synthesized via cyclotetramerization of phthalonitrile derivatives (CN^p/CN^np) in the presence of zinc (II) and magnesium (II) metal ions. After synthesis and characterization processes, anticholinesterase, anti-α-glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and nonperipheral Zn^II and Mg^II phthalocyanines were investigated. The inhibitory effects of metalated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and α-glucosidase enzymes were tested by spectrophotometric method. Theor. methods were used to compare both the chem. and biol. activities of the studied phthalonitrile derivatives and metalated phthalocyanine compounds

Category: nitriles-buliding-blocks, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.

Yadav, Sanjay;Suresh, Surisetti research published 《 N-Heterocyclic Carbene (NHC)-Catalyzed Intramolecular Stetter Reaction to Access Dibenzo-fused Seven-membered Heterocycles》, the research content is summarized as follows. Herein, an NHC-catalyzed transformation to access dibenzo-fused seven-membered heterocyclic compounds via intramol. Stetter reaction under ambient conditions was delineated. A range of dibenzo[b,f]oxepine and dibenzo[b,f]thiepine derivatives was generated in very good to excellent yields. The 1,4-dicarbonyl functionality of a representative derivative was undergone further heterocyclization via Paal-Knorr reaction.

Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Category: nitriles-buliding-blocks.

Xue, Yisong;Tang, Wenhao;Si, Conghui;Lu, Qifang;Guo, Enyan;Wei, Mingzhi;Pang, Yingping research published 《 0D/2D/1D silver-decorated CuPc/Bi₂MoO₆ Z-scheme heterojunctions enable better visible-light-driven tetracycline photocatalysis》, the research content is summarized as follows. The pursuit of a desirable photocatalytic technol. has always been accompanied by photocatalyst design and development, marking high activity, long-term stability, and low cost. Herein, an in-situ deposition approach is used to integrate plasmonic 0D Ag nanoparticles on the surface of 2D slice-like 2,9,16,23-tetranitrocopper(II) phthalocyanine (CuPc) sensitized 1D Bi₂MoO₆ nanofibers (Ag-CuPc/Bi₂MoO₆) for visible-light-induced tetracycline (TC) photocatalysis. Benefiting from the combination of 2D CuPc sensitization, and surface plasmon resonance (SPR) effect of 0D Ag nanoparticles, we exptl. find that the Ag-CuPc/Bi₂MoO₆ nanofibers boost the visible-light utilization efficiency, promote charge transfer, and separation, and accelerate electron redox transformation in TC photocatalysis. The superior photocatalytic activity is attributed to the strong interfacial interaction, and Z-scheme heterojunction synergy in Ag-CuPc/Bi₂MoO₆ nanofibers. This work opens new horizons for the delicate design of promising Z-scheme visible-light photocatalysts for the removal of antibiotics in wastewater, realizing water purifications.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. HPLC of Formula: 31643-49-9.

Xu, Yunyun;Jiang, Cheng;Gong, Hao;Xue, Hairong;Gao, Bin;Li, Peng;Chang, Kun;Huang, Xianli;Wang, Tao;He, Jianping research published 《 Single atom site conjugated copper polyphthalocyanine assisted carbon nanotubes as cathode for reversible Li-CO₂ batteries》, the research content is summarized as follows. Recently, Li-CO₂ battery has gradually become a research hotspot due to its high discharge capacity, energy d. and environmental benefits. However, it has been an important problem for researchers because of its slow decomposition kinetics and difficult to generalize to practical application. Herein, we prepared copper polyphthalocyanine-carbon nanotubes composites (CuPPc-CNTs) by solvothermal in-situ polymerization of copper phthalocyanine on the surface of carbon nanotubes as cathode for reversible Li-CO₂ batteries, which exhibits a high discharge capacity of 18,652.7 mAh·g^-1 at c.d. of 100 mA·g^-1, 1.64 V polarization at 1,000 mA·g^-1, and a stable cycles number of 160 is close to 1,630 h of charge-discharge process at 200 mA·g^-1. Copper polyphthalocyanine has highly efficient copper single-atom catalytic sites with excellent CO₂ adsorption and activation, while carbon nanotubes provide a conductive network. The synergistic effect of the two compounds enables it to have excellent catalytic activity. The d. functional theory (DFT) calculation proved that the addition of copper polyphthalocyanine significantly improved the CO₂ adsorption and activation process. This study provides an opportunity for the research of covalent organic polymers (COPs) single-atom catalyst in Li-CO₂ battery field.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., HPLC of Formula: 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Reference of 105-34-0.

Xu, Wen-Bin;Ghorai, Samir;Huang, Wenyu;Li, Changkun research published 《 Rh(I)/Bisoxazolinephosphine-Catalyzed Regio- and Enantioselective Allylic Substitutions》, the research content is summarized as follows. Rhodium(I)/bisoxazolinephosphine combination has been developed as a general catalyst to achieve the dynamic kinetic asym. allylation of a variety of nitrogen, carbon, oxygen, and sulfur pronucleophiles from branched racemic allylic carbonates. Exclusive branch-selectivity and up to 99% enantiomeric excess could be obtained under neutral conditions. Linear allylic substrates (both Z and E) could be converted to the same chiral branched products with excellent regio- and enantioselectivities as well. Chiral π-allyl-Rh(III)/NPN intermediate was isolated and characterized to understand the origin of the high selectivities.

Reference of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Synthetic Route of 1835-49-0.

Xu, Weifeng;Liu, Xiang;Cai, Jianzhe;Xue, Tiemeng;Tang, Kewen research published 《 Synthesis of reusable cyclodextrin polymers for removal of naphthol and naphthylamine from water》, the research content is summarized as follows. As one group of important naphthalene derivatives, naphthol and naphthylamine are diffusely employed as dye intermediates. The presence of naphthol and naphthylamine in water systems may pose risks to the environment and public health due to their carcinogenicity. In this study, four mesoporous polymers prepared by β-cyclodextrin derivatives and tetrafluoroterephthalonitrile were obtained and applied to adsorbing 1-naphthylamine, 2-naphthylamine, 1-naphthol, and 2-naphthol from water. The impact of adsorption time, initial concentration of naphthol and naphthylamine, and temperature on the adsorption efficiency of the four polymers were explored sep. The four polymers present fast adsorption kinetics toward naphthol and naphthylamine, attaining 93 ∼ 100% of adsorption equilibrium uptake for 1-naphthol, 1-naphthylamine, 2-naphthylamine in 15 min, and 87 ∼ 90% of equilibrium uptake for 2-naphthol in 15 min. The kinetics could be depicted well by the pseudo-second-order kinetic model. The adsorption isotherms of the four polymers toward naphthol and naphthylamine accord with the Redlich-Peterson or Sips model. The maximum adsorption capacities of 1-naphthylamine, 2-naphthylamine, 1-naphthol, and 2-naphthol are 189.9 mg/g, 82.8 mg/g, 137.7 mg/g, and 88.7 mg/g, resp. The adsorption ratio increases fast with reducing the initial concentration of naphthol and naphthylamine, and the adsorption ratio of naphthol and naphthylamine in 5 mg/L can achieve over 95% in 25 °C. In addition, the four polymers can be effortlessly regenerated by a gentle and simple washing procedure with little reduction in performance. The adsorption performance of the four polymers toward the four naphthalene derivatives can be improved by increasing the adsorption temperature In conclusion, the prepared β-cyclodextrin polymers exhibit rapid water treatment in removing the four low-concentration naphthalene derivatives with convenient regeneration and good reusability.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Synthetic Route of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Safety of 4-Ethynylbenzonitrile.

Xu, Tianhao;Zhou, Xiangbing;Han, Yuhui;Zhang, Liangwei;Liu, Long;Huang, Tianzeng;Li, Chunya;Tang, Zhi;Wan, Shungang;Chen, Tieqiao research published 《 Palladium-catalyzed stereo-selective three-component cis-1,2-arylalkynylation of bicyclic alkenes with aryltriflates and terminal alkynes》, the research content is summarized as follows. Synthesis of (1S,2R,3S,4R)-2-(arylethynyl)-3-(aryl)bicyclo[2.2.1]heptanes I [R = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar = Ph, 2-MeC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, C(O)Me] via a palladium-catalyzed stereo-selective cis-1,2-arylalkynylation of bicyclic alkenes with aryl triflates and terminal alkynes was developed. This reaction showed high functional group tolerance and could be applied to the modification of bioactive mols. This three-component reaction provided a practical method for preparing the value-added bicyclo[2.2.1]heptanes derivatives

Safety of 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts