Month: October 2022

《Access to pyridines via cascade nucleophilic addition reaction of 1,2,3-triazines with activated ketones or acetonitriles》 was written by Zhang, Yuan; Luo, Han; Lu, Qixing; An, Qiaoyu; Li, You; Li, Shanshan; Tang, Zongyuan; Li, Baosheng. HPLC of Formula: 614-16-4This research focused ontriazine acetonitrile tandem regioselective cycloaddition nucleophilic addition; ketone triazine tandem regioselective cycloaddition nucleophilic addition; pyridine preparation. The article conveys some information:

The cascade nucleophilic addition reactions of 1,2,3-triazines with activated acetonitriles or ketones, which were used to construct highly substituted pyridines that were not easily accessed by conventional methods was reported. The strategy addressed some structural diversity issues currently facing medicinal chem., and the resulting pyridines was used as convenient precursors for the synthesis of related pharmaceuticals. This method was applied to the syntheses of the marketed drug etoricoxib and several biol. important mols. in a few steps. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Tris(triazolo)triazine-based emitters for solution-processed blue thermally activated delayed fluorescence organic light-emitting diodes》 was written by Hundemer, Fabian; Crovini, Ettore; Wada, Yoshimasa; Kaji, Hironori; Braese, Stefan; Zysman-Colman, Eli. Quality Control of 4-FluorobenzonitrileThis research focused onTristriazolotriazine emitters processed blue thermally fluorescence organic lightemitting diodes. The article conveys some information:

We report a new emitter 3,4,5-3TCz-TTT based on a tris(triazolo)triazine acceptor that shows thermally activated delayed fluorescence and cross-compare its performance with the recently reported analog, 3DMAC-TTT. These compounds show blue emission and delayed fluorescence with delayed lifetimes on the order of milliseconds. Solution-processed organic light-emitting diodes achieving maximum external quantum efficiencies, EQEmax, of 5.8% for 3,4,5-3TCz-TTT and 11.0% for 3DMAC-TTT.4-Fluorobenzonitrile(cas: 1194-02-1Quality Control of 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Quality Control of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C18H16FNO2On May 15, 2016 ,《An integrated nematic liquid crystal in-fiber modulator derivates from capillary optical fiber》 appeared in Optics Communications. The author of the article were Guo, Xiaohui; Yang, Xinghua; Li, Song; Liu, Zhihai; Hu, Minggang; Qu, Bin; Yuan, Libo. The article conveys some information:

A novel liquid crystal integrated modulation-depth-adjustable in-fiber modulator is proposed. The liquid crystal is encapsulated in a specially designed capillary optical fiber with tubular structure. The exptl. results show that the liquid crystal under the elec. field can influence the light intensity in the tubular core of the fiber. The light at 632.8 nm in the circular waveguide can be modulated by only 2.71×10-2 nL of the liquid crystals under elec. field. The wide range of modulation-depth from 23% to 50% can be obtained by adjusting the strength of the external elec. field. In addition, the modulator shows good stability and repeatability. This work has great potentials in integrated in-fiber optical devices such as tunable modulators, optical switches and elec. field sensors. In the experimental materials used by the author, we found 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5Computed Properties of C18H16FNO2)

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Computed Properties of C18H16FNO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C10H7BrN2On September 18, 2003 ,《Seco-C/D Ring Analogues of Ergot Alkaloids. Synthesis via Intramolecular Heck and Ring-Closing Metathesis Reactions》 was published in Organic Letters. The article was written by Kalinin, Alexey V.; Chauder, Brian A.; Rakhit, Suman; Snieckus, Victor. The article contains the following contents:

Intramol. Heck and ring-closing metathesis reactions on key intermediates I and II, resp., provide efficient entries into seco-C/D ring analogs of Ergot alkaloids III and IV, compounds of potential synthetic and biol. interest. In the experiment, the researchers used many compounds, for example, 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Computed Properties of C10H7BrN2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Computed Properties of C10H7BrN2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Iwao, Masatomo; Motoi, Osamu published their research in Tetrahedron Letters on August 14 ,1995. The article was titled 《Methodology for the efficient synthesis of 3,4-differentially substituted indoles. Fluoride ion-induced elimination-addition reaction of 1-triisipropylsilylgramine methiodides》.Recommanded Product: 89245-35-2 The article contains the following contents:

1-Triisopropylsilylgramine methiodide reacted smoothly with a variety of nucleophiles in the presence of tetrabutylammonium fluoride to give 3-substituted indoles. The 3,4-disubstituted indoles were efficiently synthesized by sequential use of 4-selective lithiation of 1-triisopropylsilylgramine and this new substitution reaction. The experimental process involved the reaction of 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Recommanded Product: 89245-35-2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Recommanded Product: 89245-35-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Fluorinated/non-fluorinated bisphenoxy benzyl ether zinc(II) phthalocyanine: Synthesis, photoinduced intramolecular electron transfer and intermolecular energy transfer》 was published in Journal of Luminescence in 2020. These research results belong to Guo, Ruotao; Chen, Kuizhi; Yu, Zhiqiang; Ye, Qiuhao; Xiao, Wenling; Huang, Bingcheng; Guan, Xinqiao; Peng, Yiru. Electric Literature of C8H6BrN The article mentions the following:

Two novel series of fluorinated and non-fluorinated bisphenoxy benzyl ether with cyano/pentyl terminal groups zinc(II) phthalocyanines were synthesized. Their structures were characterized by elemental anal., IR, 1H NMR, 13C NMR, ESI-MS and MALDI-TOF-MS methods. The photophys. properties, photoinduced intramol. electron transfer, and photoinduced intramol. energy transfer of fluorinated and non-fluorinated phthalocyanines were compared by UV-Vis and fluorescence spectroscopic methods. These properties exhibited fluorinated substituents and terminal groups nature dependence. Fluorinated zinc(II) phthalocyanine with pentyl ester terminal groups had the highest molar absorption coefficient, fluorescence intensity and fluorescence lifetime. Non-fluorinated zinc(II) phthalocyanine with cyano terminal groups exhibited the highest energy transfer efficiency. In addition to this study using 4-Cyanobenzyl bromide, there are many other studies that have used 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《C-Alkylation of Various Carbonucleophiles with Secondary Alcohols under CoIII-Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Chakraborty, Priyanka; Garg, Nidhi; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker. SDS of cas: 31938-07-5 The article mentions the following:

Oxindoles have been successfully α-alkylated under Cp*CoIII catalysis by a vast array of secondary alcs., including cyclic, acyclic, sym., and unsym., to produce C-alkylated oxindoles. This protocol was also extended to the α-alkylation of N,N-di-Me barbituric acid and benzyl cyanides. The kinetic profile and other preliminary mechanistic investigations suggest a first-order reaction rate in oxindoles and catalysts. A plausible catalytic cycle is proposed on the basis of the kinetic profile, of other preliminary mechanistic investigations, and of previous mechanistic studies on similar transformations, whereas d. functional theory calculations provide insight into the nature of the active species. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.SDS of cas: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Metal-Free Solvent/Base-Switchable Divergent Synthesis of Multisubstituted Dihydrofurans》 was written by Gore, Babasaheb Sopan; Kuo, Chiao-Ying; Garkhedkar, Amol Milind; Chang, Yu-Lun; Wang, Jeh-Jeng. Quality Control of 3-Oxo-3-phenylpropanenitrile And the article was included in Organic Letters in 2020. The article conveys some information:

A general protocol for the synthesis of multisubstituted 2,3-dihydrofuran-2-carbonitriles and 4,5-dihydrofuran-3-carbonitriles was demonstrated under a metal-free regime with the same oxidant, TBHP. By simply switching the reaction solvent and base, the reaction proceeds via two pathways. An unexpected -CN group migration rearrangement and hydroxylation have occurred in nonpolar and polar solvents, resp., under the reported conditions. Furthermore, the source of the hydroxyl group and hydrogen in the reaction is indirectly confirmed with isotope labeling studies. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Quality Control of 3-Oxo-3-phenylpropanenitrile) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Quality Control of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《A facile synthesis of mesoporous graphitic carbon nitride supported palladium nanoparticles as highly effective and reusable catalysts for Stille coupling reactions under mild conditions》 was written by Kalay, Erbay; Cetin, Sultan; Kolemen, Safacan; Metin, Onder. Related Products of 623-00-7 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

The development of a Stille coupling protocol that is operable under moderate conditions without using a base is highly required for the synthetic organic chem. community, which requires an efficient nanocatalyst. In this respect, addressed herein is a facile one-pot synthesis of mesoporous graphitic carbon nitride (mpg-CN) supported Pd NPs, denoted as mpg-CN/Pd hereafter, and investigation of their catalytic activity in Stille cross-coupling reactions for the first time. It has been demonstrated that mpg-CN nanosheets can serve as not only a support material but also a stabilizer for the generation of 4.5 nm Pd NPs. The ecofriendly generated heterogeneous nanocatalyst was characterized by TEM, XRD, XPS, BET surface area and ICP-MS anal. The mpg-CN/Pd nanocatalysts showed high activity in the Stille coupling reaction of a variety of electron-deficient and electron-rich aryl iodides/bromides and two different organostannanes with a wide substrate scope to afford the corresponding biaryls without using any bases and addnl. ligands under relatively mild conditions. The catalyst can be easily recovered from the reaction medium by centrifugation. It can be reused at least 5 times without any loss of activity. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Related Products of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《De Novo Protocol for the Construction of Benzo[a]fluorenes via Nitrile/Alkene Activation》 was written by Gore, Babasaheb Sopan; Chiang, Chun-Hsien; Lee, Chein Chung; Shih, Yi-Lun; Wang, Jeh-Jeng. Application of 614-16-4 And the article was included in Organic Letters in 2020. The article conveys some information:

Unprecedented chemo- and regioselective synthesis of benzo[a]fluorenes and naphthamide-substituted benzo[a]fluorenes were constructed from the reaction of (E)-2-aroyl-3-(2-(arylalkynes/alkenes)aryl)acrylonitrile scaffolds under metal-free conditions via the activation of nitriles and alkenes, resp. A tentative reaction mechanism was proposed for this homofunctionalization of nitriles. Control experiments showed that the reaction proceeds via selective nitrile or alkene protonation, depending upon the substrates. Addnl., we demonstrated an alternative expeditious route for the synthesis of disubstituted benzo[a]fluorenes in the presence of TfOH alone. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Application of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts