Month: October 2022

Ressmann, Anna K.; Schwendenwein, Daniel; Leonhartsberger, Simon; Mihovilovic, Marko D.; Bornscheuer, Uwe T.; Winkler, Margit; Rudroff, Florian published the artcile< Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes>, Computed Properties of 38487-85-3, the main research area is aldehyde quantification high throughput assay aminobenzamidoxime derivative.

The selective and direct reduction of carboxylic acids into the corresponding aldehydes by chem. methods is still a challenging task in synthesis. Several reductive and oxidative chem. methods are known to produce aldehydes, but most of them require expensive reagents, special reaction conditions, are 2-step procedures and often lack chemoselectivity. Nature provides an elegant tool, so called carboxylic acid reductases (CARs) for the direct reduction of carboxylic acids to aldehydes. Discovery as well as engineering of novel CAR enzymes necessitates a robust, product selective high-throughput assay (HTA). The authors report a simple and fast HTA that allows the substrate-independent and chemoselective quantification of aldehydes (irresp. of their chem. structure) and is sensitive to the nM range. The HTA was validated by NMR and GC analyses and in microbial cells by reexamination of the substrate scope of CAR from Nocardia iowensis (CARNi). The results were fully consistent with reported data.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: ANT (Analyte), RCT (Reactant), SPN (Synthetic Preparation), ANST (Analytical Study), RACT (Reactant or Reagent), PREP (Preparation). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Computed Properties of 38487-85-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Smith, William J. III; Sawyer, J. Scott published the artcile< A novel and selective method for the N-arylation of indoles mediated by KF/Al2O3>, HPLC of Formula: 94087-40-8, the main research area is regioselective arylation indole potassium fluoride.

Indole was treated with aryl electrophiles in the presence of 37% KF/Al2O3 and catalytic 18-crown-6 in DMSO at 120 °C to give regioselectively 1-arylindoles in fair to excellent yield. Electrophiles containing electronically unfavorable substitution patterns or leaving groups, such as 3-chlorobenzonitrile, coupled effectively under the reaction condition. For example, the potassium-fluoride mediated arylation of 1H-indole with 3-chloro-2-fluorobenzonitrile gave 3-chloro-2-(1H-indol-1-yl)benzonitrile (68% yield).

Tetrahedron Letters published new progress about Arylation, regioselective. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, HPLC of Formula: 94087-40-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeng, Ge; Liu, Jichao; Shao, Yinlin; Zhang, Fangjun; Chen, Zhongyan; Lv, Ningning; Chen, Jiuxi; Li, Renhao published the artcile< Selective Synthesis of β-Ketonitriles via Catalytic Carbopalladation of Dinitriles>, Computed Properties of 21667-62-9, the main research area is dinitrile arylboronic acid palladium carbopalladation addition catalyst; ketonitrile preparation.

A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition of organoboron reagents to dinitriles has been developed. This method provides excellent functional-group tolerance, a broad scope of substrates, and the convenience of using com. available substrates. The method is expected to show further utility in future synthetic procedures.

Journal of Organic Chemistry published new progress about Addition reaction. 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Computed Properties of 21667-62-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Chong; Yuan, Jing; Zhang, Zhenfeng; Gridnev, Ilya D.; Zhang, Wanbin published the artcile< Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center>, Name: 3-(3-Chlorophenyl)-3-oxopropanenitrile, the main research area is arylcyclopentanone enantioselective preparation; rhodium catalyst enantioselective intramol hydroacylation arylenal alkene isomerization; mechanism transition state energy rhodium catalyzed enantioselective hydroacylation arylenal; alkene isomerization; cycloketones; hydroacylation; rhodacycle; β-H elimination.

A new transformation pattern for enantioselective intramol. hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals such as I (or their Z isomers) were converted to C3- or C3,C5-chirogenic cyclopentanones such as II with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theor. calculated and the origin of the stereoselection is rationally explained.

Angewandte Chemie, International Edition published new progress about Cyclopentanones Role: SPN (Synthetic Preparation), PREP (Preparation) (3-aryl-2,2-disubstituted). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Name: 3-(3-Chlorophenyl)-3-oxopropanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Park, Kyeong-Yong; Lee, Jinyong; Park, Seong Jun; Heo, Jung-Nyoung; Lim, Hwan Jung published the artcile< Regioselective Synthesis of 1,2- and 1,4-Dihydroquinolines by Palladium-Catalyzed Intramolecular N-Arylation>, Related Products of 886761-96-2, the main research area is bromoaryl enamine palladium intramol arylation catalyst; dihydroquinoline regioselective preparation.

A series of 1,2- and 1,4-dihydroquinolines has been successfully prepared The Pd-catalyzed intramol. N-arylation of Z-enamines, formally prepared by the Horner-Wadsworth-Emmons olefination, proceeded efficiently to furnish the cyclized products. Depending on the cyclization conditions, substituted 1,4-dihydroquinolines and further isomerized 1,2-dihydroquinolines were independently obtained in high yields with an excellent control of isomerization of the double bond.

Advanced Synthesis & Catalysis published new progress about Arylation (intramol.). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Related Products of 886761-96-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bagley, Mark C.; Chapaneri, Krishna; Glover, Christian; Merritt, Eleanor A. published the artcile< Simple microwave-assisted method for the synthesis of primary thioamides from nitriles>, Application of C6H11NO2, the main research area is nitrile reaction ammonium sulfide microwave irradiation; thioamide primary preparation.

Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol, at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 °C or 130 °C in 15-30 min for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H2S under high pressure, proceeds in the absence of base and provides thioamides usually without the need for chromatog. purification

Synlett published new progress about Microwave irradiation. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application of C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Porter, Thomas C.; Smalley, Robert K.; Teguiche, Mabrouk; Purwono, Bambang published the artcile< Tetrazolo[1,5-a]quinolines and 1,2,3-triazolo[1,5-a]quinazolines by the action of cyano carbanions on 2-azidoaryl carbonyl compounds>, Quality Control of 658-99-1, the main research area is tetrazoloquinoline preparation; quinoline tetrazolo preparation; triazoloquinazoline preparation; quinazoline triazolo preparation; cyano carbanion azidophenyl carbonyl compound cyclocondensation.

In protic solvents, 2-N3C6H4CHO undergoes base-catalyzed condensation with cyano carbanions to yield tetrazolo[1,5-a]quinolines, whereas in aprotic media 1,2,3-triazolo[1,5-a]quinazolines are formed. Triazoloquinazolines are also obtained from 2-N3C6H4Ac and from 2-N3C6H4CN, whereas with 2-N3C6H4COCl hydroxytetrazoloquinolines result. 2,1-Oxazolo[4,3-c]tetrazolo[1,5-a]quinolines are obtained by the action of selected cyano carbanions on 2-N3C6H4CN+O- and a 1,2,3-triazolo[1,5-a]quinoline by base-catalyzed condensation of 2-N3C6H4CN with (PhCH2)2CO.

Synthesis published new progress about Aromatic carbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 658-99-1 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5F2N, Quality Control of 658-99-1.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Du, Bingnan; Jiang, Xiaoqing; Sun, Peipei published the artcile< Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group [Erratum to document cited in CA158:330848]>, HPLC of Formula: 21423-84-7, the main research area is erratum halosuccinimide ortho halogenation arylnitrile palladium catalyst; nitrile aromatic ortho halogenation halosuccinimide palladium catalyst erratum.

The authors provide clarification that there is competition during the halogenation of 4-methoxybenzonitrile and revise the corresponding results.

Journal of Organic Chemistry published new progress about Halogenation catalysts. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, HPLC of Formula: 21423-84-7.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Si, Chong; Myers, Andrew G. published the artcile< A Versatile Synthesis of Substituted Isoquinolines>, SDS of cas: 6136-93-2, the main research area is isoquinoline preparation cyclization imine nitrile.

This communication present the direct assembly of substituted isoquinolines and biisoquinolines for use in versatile and unique methodologies for the construction of heterocyclic compounds

Angewandte Chemie, International Edition published new progress about Condensation reaction. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, SDS of cas: 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Booth, Brian L.; Collis, Alan published the artcile< One-step synthesis of N1-(1-benzylisoquinolin-3-yl)phenylacetamidinium trifluoromethanesulfonate derivatives from phenylacetonitriles and trifluoromethanesulfonic acid>, COA of Formula: C8H5F2N, the main research area is phenylacetonitrile cyclotrimerization triflic acid; benzylisoquinolinylphenylacetamidinium triflate.

The phenylacetonitriles 3,4-R1R2C6H3CH2CN (I, R1 = H, Me, Cl, R2 = H; R1 = H, R2 = Cl, F; R1 = R2 = Cl, F) and 2-cyclohexylphenylacetonitrile react with CF3SO3H under various conditions to give the corresponding title salts, e.g. II, in moderate to high yields. This novel cyclotrimerization reaction can also be carried out with I (R1 = R2 = H) using FSO3H and, in low yield, with HBF4.Et2O while ClSO3H, 4-MeC6H4SO3H, and HCl/ZnCl2 give only PhCH2CONH2 under similar conditions. Reaction of I (R1 = R2 = H) with dry HCl resulted mainly in the formation of 1,3,5-tribenzyltriazine. Isoquinoline formation is not observed upon reaction of either I (R1 = H, MeO, R2 = MeO) with CF3SO3H, but complex product mixtures probably resulting from Houben-Hoesch reactions are obtained. I (R1 = H, R2 = AcO) gives a low yield of the Fries rearrangement product.

Journal of Chemical Research, Synopses published new progress about Cyclotrimerization. 658-99-1 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5F2N, COA of Formula: C8H5F2N.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts