Month: October 2022

Garnes-Portoles, Francisco; Greco, Rossella; Oliver-Meseguer, Judit; Castellanos-Soriano, Jorge; Consuelo Jimenez, M.; Lopez-Haro, Miguel; Hernandez-Garrido, Juan Carlos; Boronat, Mercedes; Perez-Ruiz, Raul; Leyva-Perez, Antonio published an article in 2021. The article was titled 《Regioirregular and catalytic Mizoroki-Heck reactions》, and you may find the article in Nature Catalysis.Recommanded Product: 2-Bromobenzonitrile The information in the text is summarized as follows:

Here, the ligand-free, few-atom palladium clusters in solution catalyze the α-selective intramol. Mizoroki-Heck coupling of iodoaryl cinnamates, and mechanistic studies support the formation of a sterically encumbered cinnamate-palladium cluster intermediate was showed. Following this rationale, the α-selective intermol. coupling of aryl iodides with styrenes was also achieved with palladium clusters encapsulated within fine-tuned and sterically restricted zeolite cavities to produce 1,1-bisarylethylenes, which are further engaged with aryl halides by a metal-free photoredox-catalyzed coupling. These ligand-free methodologies significantly expand the chem. space of the Mizoroki-Heck coupling. The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Li, Changan; Swenson, Dale C.; MacGillivray, Leonard R. published an article in Chemistry – A European Journal. The title of the article was 《Programming Rapid Functional Group Diversification into a Solid-State Reaction: Aryl Nitriles for Self-Assembly, Click Reactivity, and Discovery of Coexisting Supramolecular Synthons》.SDS of cas: 17201-43-3 The author mentioned the following in the article:

A method to rapidly diversify the mols. formed in organic crystals is introduced, with aryl nitriles playing a novel dual role as both hydrogen-bond acceptors and modifiable organic groups. The discovery of coexisting supramol. synthons in the same crystal is also described. The general concept is demonstrated by using a bis(aryl nitrile) alkene that undergoes a hydrogen-bond-directed intermol. [2+2] photodimerization to form a tetra(aryl nitrile)cyclobutane. The product is readily converted by click reactivity to a tetra(aryl tetrazole) and by hydrolysis to a tetra(aryl carboxylic acid). The integration of aryl nitriles into solid-state reactions opens broad avenues to post-modify products formed in crystalline solids for rapid diversification. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3SDS of cas: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.SDS of cas: 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 105942-08-3In 2017 ,《Experimental investigation of the influence of reaction atmosphere on the pyrolysis of printed circuit boards》 appeared in Applied Energy. The author of the article were Evangelopoulos, Panagiotis; Kantarelis, Efthymios; Yang, Weihong. The article conveys some information:

Printed circuit boards (PCB) are one of the most challenging fractions of waste elec. and electronic equipment (WEEE) in terms of recycling due to their complexity and diversity. Pyrolysis seems to be a promising alternative for production of energy carriers from its organic fraction with simultaneous recovery of metals. Reaction atm. is among the process parameters that affects the thermal decomposition as well as the products formation and distribution. In this study, the decomposition of two different PCB fractions in inert and steam atmospheres has been investigated by means of thermogravimetric anal. (TGA) and lab scale fixed bed reactor experiments It was found that the decomposition of the tested materials in steam atm. starts at lower temperatures and proceeds slower compared to the N2 atmosphere. Moreover, a two-step decomposition has been observed on the PCB sockets fraction due to the fact that high amount of antimony oxide was present, a common additive for improving the flame retardancy, which have been also observed on previous studies (Wu et al., 2014). The presence of steam influence the pyrolysis gas composition and promotes addnl. vaporisation of antimony as verified by powder X-ray diffraction (XRD) and SEM (SEM). Finally, the liquid fraction has been qual. analyzed using a GC/MS in order to determine the brominated compounds as well as other compounds that are produced from this process. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Recommanded Product: 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of C8H6BrNIn 2020 ,《Synthesis and antitumor activity of novel gibberellin derivatives with tetracyclic diterpenoid skeletons》 appeared in Medicinal Chemistry Research. The author of the article were Zhu, Shi-ying; Luo, Fa-zeng; Sun, Ping-Hua. The article conveys some information:

Abstract: Gibberellic acid (GA3) is a tetracyclic diterpene compound which displays interesting bioactivities. Recently, its potential use for preparing antitumor drug leads has been highlighted, and various modification methods of GA3 have been reported. Aiming at investigating GA3 derivatives with potential antitumor activities, ring distortion of GA3 under different conditions was carried out, and this was followed with amidation or substitution, yielding four series of derivatives The chem. structure of these compounds were analyzed by 1H-NMR, 13C-NMR, HRMS, FTIR and polarimetry, and SXRD was employed to further confirm the spatial configurations of derivatives 3c and 7d. The antitumor activities of three series of derivatives were evaluated by using MTT assay and ELISA. Results shows that, among amide derivatives, compounds with a saturated linear amide showed better activity than those with an aromatic amide. Among ester derivatives, compounds with a meta-substituted benzyl group showed better activities than those with a para-substituted benzyl group. The antitumor activity of ester derivatives might possibly be linked with the inhibition of FGFR1 activation and KDR activation. Overall, this study discussed how the antitumor activity of GA3 was formed, thereby assisting the future design of more effective active GA3 derivatives [graphic not available: see fulltext]. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Category: nitriles-buliding-blocksIn 2012 ,《Quantitative structure-property relationships studies on free-radical polymerization chain-transfer constants for styrene》 appeared in Journal of Applied Polymer Science. The author of the article were Xu, Jie; Wang, Lei; Zhang, Hui; Shen, Xiaolin; Liang, Guijie. The article conveys some information:

Quant. structure-property relationships (QSPR) studies were performed for kinetic chain-transfer constants of 90 agents on styrene polymerization at 60°. By using stepwise multi-linear regression anal. (MLRA) and artificial neural network (ANN), linear and nonlinear models containing seven descriptors were obtained with R2 of 0.7866 and 0.8661 for the training set, resp. The reliability of the proposed models was validated through the test set. The descriptors involved in the models are related to the mol. conformational changes and some functional groups. As these descriptors are directly calculated from the mol. structure, the proposed models can be employed to estimate the chain-transfer constants for styrene. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Category: nitriles-buliding-blocks)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 4-BromobenzonitrileIn 2022 ,《Characterization of Radioiodinated Diaryl Oxadiazole Derivatives as SPECT Probes for Detection of Myelin in Multiple Sclerosis》 appeared in ACS Chemical Neuroscience. The author of the article were Watanabe, Hiroyuki; Maekawa, Rinka; Iikuni, Shimpei; Kakae, Masashi; Matsuo, Nagisa; Shirakawa, Hisashi; Kaneko, Shuji; Ono, Masahiro. The article conveys some information:

Multiple sclerosis (MS) is an intractable disease of the central nervous system that results from destruction of the myelin sheath. Direct measurement of de- and remyelination is required for monitoring the disease stage of MS, but no useful method has been established. In this study, we characterized four diaryl oxadiazole derivatives as novel myelin-imaging probes for single photon emission computed tomog. (SPECT). All the diaryl oxadiazole derivatives penetrated the blood-brain barrier in normal mice. Among them, the highest ratio of radioactivity accumulation in the white matter (myelin-rich region) against the gray matter (myelin-deficient region) was observed at 60 min postinjection of [125I]1,3,4-PODP-DM in ex vivo autoradiog. using normal mice. In the blocking study with ex vivo autoradiog., the radioactivity accumulation of [125I]1,3,4-PODP-DM in the white matter markedly reduced. [125I]1,3,4-PODP-DM detected demyelination in the ex vivo autoradiog. images of not only the spinal cord of the exptl. autoimmune encephalomyelitis mice but also the brain after lysophosphatidylcholine (LPC) injection. In addition, [123I]1,3,4-PODP-DM could image LPC-induced demyelination in the mouse brain with SPECT. These results suggest that [123I]1,3,4-PODP-DM may be a potential SPECT probe for imaging myelin in MS. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Name: 4-Bromobenzonitrile) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Name: 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 31938-07-5In 2021 ,《Silver/manganese dioxide nanorod catalyzed hydrogen-borrowing reactions and tert-butyl ester synthesis》 was published in Journal of Chemical Research. The article was written by Luo, Huanhuan; Yang, Yike; Yang, Bobin; Xu, Zhaojun; Wang, Dawei. The article contains the following contents:

Silver/manganese dioxide (Ag@MnO2) nanorods are synthesized and characterized by SEM, transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, and XPS. It was discovered that Ag@MnO2 nanorods can realize hydrogen-borrowing reactions in high yields and are also effective for the synthesis of tert-Bu esters from aryl cyanides and tert-Bu hydroperoxide in a short period of time. Mechanistic experiments revealed that this catalytic system acts as a Lewis acid in hydrogen-borrowing reactions, while the synthesis of tert-Bu esters occurs through a radical pathway. This is the first report on the excellent catalytic activity of Ag@MnO2 nanorods as a catalyst. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Related Products of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Quality Control of 2-BromobenzonitrileIn 2021 ,《Arylbiamidines: synthesis and structural studies en route to anticancer applications》 was published in New Journal of Chemistry. The article was written by Grytsai, Oleksandr; Goncalves, Leticia Christina Pires; Bardovskyi, Rostyslav; Hamouda-Tekaya, Nedra; Rocchi, Stephane; Ronco, Cyril; Benhida, Rachid. The article contains the following contents:

Biamidines are a unique and poorly studied class of nitrogenous compounds prone to tautomerization and H-bonding. Four series of heteroaryl diarylbiamidines were synthesized and the antimelanoma activity and physicochem. properties of the resulting 37 new compounds were evaluated. The dimethylthiazolyl 3-bromophenyl biamidine derivative B6 (I) inhibits the growth of six different melanoma cell lines, having higher activity than the pos. control drug, the B-RAF inhibitor PLX4032. This study introduces diarylbiamidines as promising frameworks for drug discovery. In addition to this study using 2-Bromobenzonitrile, there are many other studies that have used 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile) was used in this study.

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Quality Control of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application In Synthesis of 2-BromobenzonitrileIn 2021 ,《Paired Electrolysis Enabled Ni-Catalyzed Unconventional Cascade Reductive Thiolation Using Sulfinates》 was published in Journal of Organic Chemistry. The article was written by Kang, Jun-Chen; Li, Zi-Hao; Chen, Chao; Dong, Li-Kun; Zhang, Shu-Yu. The article contains the following contents:

Herein, authors have reported a nickel-catalyzed cascade reductive thiolation of aryl halides with sulfinates driven by paired electrolysis. This protocol uses sulfinates as the sulfur source, and various thioethers could be synthesized under mild conditions. By mechanism exploration, authors find that a cascade chem. step is allowed on the electrode interface and could alter the reaction pathway in paired electrolysis, whose findings could help the discovery of novel cascade reactions with unique reactivity. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Application In Synthesis of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Application In Synthesis of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Novel triazine-based cationic covalent organic polymers for highly efficient and selective removal of selenate from contaminated water》 was written by Lin, Wenxia; Wu, Pengcheng; Li, Rongfei; Li, Jihong; Cai, Yimin; Yuan, Lihua; Feng, Wen. HPLC of Formula: 17201-43-3This research focused ontriazine covalent organic framework selenate adsorption water purificaton; Adsorption; Contaminated water treatment; Covalent triazine framework; Selenium removal. The article conveys some information:

Selenium (Se) removal from contaminated water has become a major environmental problem in recent years. Designing efficient and selective materials for selenium adsorption is urgent and still represents a great challenge. Herein, two novel cationic covalent triazine frameworks (CTFS-Cl and CTFL-Cl) are developed for the first time and employed as a new class of Se adsorbents. The results from systematic adsorption experiments indicate that these materials can adsorb SeO2-4 in a wide range of pH values (2-11) with fast kinetics (5 min), outstanding adsorption capacity, and excellent selectivity over other competing anions. The maximum adsorption capacity achieved (149.3 mg/g by CTFS-Cl) constitutes one of the highest values among the organic polymeric materials. More importantly, after a single step adsorption, these materials can reduce the Se concentrations to lower than 10μg/L, the lowest drinking water standard in the world. The adsorption mechanism was probed by XPS technique, EDS anal., adsorption experiments, and DFT calculations, which reveals that anion exchange between Cl- and SeO2-4 is the main driving force for Se adsorption. Addnl., CTFS-Cl and CTFL-Cl perform well toward real contaminated river water sample with the residual Se being less than 8.49μg/L. This work demonstrates the excellent performance of CTFs-based materials with great application prospect for Se removal in contaminated water treatment. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3HPLC of Formula: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.HPLC of Formula: 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts