Month: October 2022

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Recommanded Product: 4-Ethynylbenzonitrile.

Wang, Zhenyu;Cao, Chengyao Kimmy;Tretyakov, Evgeny;Liu, Wei;Chen, Chao research published 《 A Facile Stereoselective Bis-Trifluoromethylselenolation Reaction of Alkynes with AgSeCF₃ and N-Bromosuccinimide》, the research content is summarized as follows. A facile stereoselective bis-trifluoromethylselenolation reaction of alkyne derivatives was realized for the first time. The reaction of alkyne derivatives and AgSeCF₃ was found to proceed in the presence of N-bromosuccinimide and water in THF and afforded bis-trifluoromethylselenolated products in moderate-to-excellent yields. The new methodol. enables one-pot synthesis with a broad substrate range.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. SDS of cas: 20099-89-2.

Wang, Yumei;Zhang, Ziwu;Deng, Lichan;Lao, Tianfeng;Su, Zhengquan;Yu, Yue;Cao, Hua research published 《 Mechanochemical Synthesis of 1,2-Diketoindolizine Derivatives from Indolizines and Epoxides Using Piezoelectric Materials》, the research content is summarized as follows. A simple and efficient mechanochem.-induced approach for the synthesis of 1,2-diketoindolizine derivatives I [R¹ = H, 8-Me, 7-OMe, etc.; Ar = Ph, 2-FC₆H₄, 4-EtC₆H₄, etc.; R² = Me, Ph, 4-FC6H4, etc.] via dicarbonylation/oxidation of indolizines and epoxides barium titanate as piezoelec. materials was developed. BaTiO₃ was used as the piezoelec. material in this transformation. This method featured no usage of solvent, simple exptl. operation, scalable potential, and high conversion efficiency, which make it attractive and practical.

SDS of cas: 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Electric Literature of 1835-49-0.

Wang, Yan;Chen, Yaqi;Bian, He;Sun, Yawei;Zhu, Lijun;Xia, Daohong research published 《 Highly selective and sensitive chiral recognition to deoxynucleosides by calixarene oligomers modified silver nanoparticles》, the research content is summarized as follows. Efficient enantiomeric sensing to deoxynucleosides by a simple method is of great importantance and remains a challenge in biochem. field. In this paper, three chiral calixarene oligomers (CA[n]P, n=4, 6, 8) were synthesized and characterized by Fourier Transform IR Spectroscopy, UV-vis spectrophotometry, CD spectroscopy , X-ray Powder Diffraction, XPS, Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry, ¹⁹F NMR and SEM. After that, the chiral calixarene oligomers capped silver nanoparticles (CA[n]P-Ag NPs, n=4, 6, 8) were prepared and characterized by FT-IR, UV-vis spectrophotometry, CD and dynamic light scattering. By using the as prepared CA[n]P-Ag NPs (n=4, 6, 8), highly selective and sensitive chiral recognition to deoxynucleosides was realized and demonstrated by UV-vis and CD. The color of the CAP-Ag NPs changes from yellow to red in the presence of β-L-2′-deoxycytidine (L-dC) or β-L-2′-deoxythymidine (L-dT) at a certain time, but not of their corresponding enantiomer β-D-2′-deoxycytidine (D-dC) or β-L-2′-deoxythymidine (D-dT). Moreover, the chiral recognition ability of CA[n]P-Ag NPs (n=4, 6, 8) toward L-deoxynucleosides was found to be in the order of CA[8]P-Ag NPs>CA[6]P-Ag NPs>CA[4]P-Ag NPs. This convenient method shows forceful prospect in developing biochem. sensors and has the potential application in enantiomeric recognition and separation of deoxynucleosides.

Electric Literature of 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: 4-Ethynylbenzonitrile.

Wang, Xuemei;Zhou, Liang;Zhang, Hongkui;Ren, Xiaoyu;Gao, Guowei;Wang, Tianli research published 《 Enantioselective γ-Addition-Driven Cascade of β,γ-Unsaturated Ketones by Ion-Pair Catalysis: Access to Chiral 1,3-Dioxolochroman Scaffolds》, the research content is summarized as follows. A highly enantioselective γ-addition-driven cascade of β,γ-unsaturated carbonyl compounds by bifunctional ion-pair catalysis was developed. With this protocol, a range of functionalized chiral 1,3-dioxolochroman derivatives I [Ar¹ = Ph, 3-FC₆H₄, 2-naphthyl, etc.; Ar² = Ph, 4-MeOC₆H₄, 3-FC₆H₄, etc.; Ar³ = Ph, 2-ClC₆H₄, 4-MeOC₆H₄, etc.] were prepared in high yields with superior stereoselectivities (>99% ee and >20:1 dr). The utility of this method was demonstrated by one-pot synthesis, scaled-up preparation, and facile transformation. Moreover, mechanistic investigations provided insights into reaction pathway and origin of chiral induction.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Synthetic Route of 20099-89-2.

Wang, Xinli;Chen, Liwei;Li, Renfu;Xie, Zuoxu;Hu, Ming;Sun, Shitao;Li, Zhenli;Hao, Jinle;Lin, Bin;Chen, Xueyuan;Xie, Lijun research published 《 Development of Rofecoxib-Based Fluorophores from ACQ to AIE by Positional Regioisomerization》, the research content is summarized as follows. The development of aggregation-induced emission luminogens (AIEgens) has attracted increasing attention due to their potential applications in various areas in recent years. In this study, a facile conversion from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) was achieved by an efficient regioisomerization strategy based on the rofecoxib scaffold. Two compounds, named PYR2 and PYR4, were identified as regioisomers of rofecoxib derivatives to show dramatically different fluorescent properties. Compound PYR2 with an ortho-substituted piperidine group showed typical AIE activity while compound PYR4 with a para-piperidine group exhibited typical ACQ behavior. Notably, compound PYR2 showed polymorphism with two forms of crystals. It was also endowed with reversible mechanochromic luminescence and acidochromic properties. The different fluorescent properties were elucidated by UV/Vis absorption spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analyzes. Its application as a security ink and in lipid droplets imaging have been demonstrated.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Synthetic Route of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Related Products of 1835-49-0.

Wang, Xinbo;Guo, Hao;Yu, Cong;Jing, Yuanju;Han, Zhaobin;Ma, Xiaohua;Yang, Chenchen;Liu, Minghua;Zhai, Dong;Zheng, Daoyuan;Pan, Yupeng;Li, Xiaoju;Ding, Kuiling research published 《 Practical Enantioselective Synthesis of Chiroptical Polymers of Intrinsic Microporosity with Circular Polarized Luminescence》, the research content is summarized as follows. Polymers with intrinsic microporosity (PIMs) have recently received increasing interest in the fields of gas separation, sensors, catalysts, and so on, due to their high microporosity and good solution processability. However, PIMs with chiral backbones are quite limited, which undoubtedly hinders their applications in many areas such as chiral separation and optoelectronics. Herein, the catalytic enantioselective synthesis of a novel cyclohexyl-fused spirobiindane-based chiral PIM is described. This novel polymer exhibits high intrinsic microporosity (S_BET = 796 m² g^-1), solubility, and good film formability. Its macroscopic chirality of the twist-bend structure was confirmed by CD. More interestingly, circular polarized luminescence (CPL) was observed for the first time in PIMs; also, to our best knowledge, this is the first nonconjugated porous CPL polymer, opening the door to explore new research fields of PIM materials, as well as providing new guidance for CPL polymer design.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Related Products of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Reference of 3032-92-6.

Wang, Xiaoshuang;Sun, Lei;Wang, Miaomiao;Maestri, Giovanni;Malacria, Max;Liu, Xiang;Wang, Yanlan;Wu, Lingang research published 《 C-I Selective Sonogashira and Heck Coupling Reactions Catalyzed by Aromatic Triangular Tri-palladium》, the research content is summarized as follows. Aromatic triangular tri-palladium cations, abbreviated as [Pd₃]⁺, have shown interesting photoelec. properties, Lewis basic character, and excellent activities in catalytic hydrogenation. Herein, authors report the highly efficient and C-I selective Sonogashira and Heck coupling reactions catalyzed by these tri-palladium complexes. Benefiting from the moderate C-I bond association energy, these tri-palladiums presented exclusive reactivities to aryl iodides over the brominated aromatics in coupling reactions. In the Sonogashira pathway, good to excellent isolated yields (71-95%) were achieved. Gram-scale reaction reached 93% of yield with palladium loading as few as 0.06 mol %. Authors also explored the electronic and steric effects for Ph alkynes and aryl iodides including heteroaromatics like thiophene, pyridine, pyrazole, and pyrazine. Similarly, yields of 71-96% were obtained for palladium loading of 1.5 mol% through catalyzed Heck coupling of aryl iodides and alkenes. The HRMS monitoring revealed that [Pd₃]⁺ maintained as whole entity during the catalytic process due to its robusness.

Reference of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Application of C4H5NO2.

Wang, Wen-Tao;Zhang, Sen;Tao, Ling-Fei;Pan, Zi-Qi;Qian, Linghui;Liao, Jia-Yu research published 《 Cooperative catalysis-enabled C-N bond cleavage of biaryl lactams with activated isocyanides》, the research content is summarized as follows. The catalytic reaction of biaryl lactams with activated isocyanides was reported for the first time. By employing a cooperative catalytic system, oxazole-containing axially chiral biaryl anilines, e.g., I were obtained in high yields with excellent enantioselectivities. The key to the success was in the atroposelective amide C-N bond cleavage with activated isocyanides.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Application of C4H5NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. SDS of cas: 31643-49-9.

Wang, Ting;Dayo, Abdul Qadeer;Wang, Zi-long;Lu, Hui-min;Shi, Cheng-yu;Pan, Zhong-cheng;Wang, Jun;Zhou, Heng;Liu, Wen-bin research published 《 Novel self-promoted phthalonitrile monomer with siloxane segments: synthesis, curing kinetics, and thermal properties》, the research content is summarized as follows. A new kind of autocatalytic phthalonitrile monomer (PN) containing siloxane segments and secondary amino groups (TSOP) was synthesized from bisphenol compound and 4-nitrophthalonitrile using K2CO3 as a catalyst. Bisphenol was a reducing agent with a Schiff base containing secondary amine groups produced by the condensation reaction of 1,3-bis(3-amino-propyl)-1,1,3,3-tetra-Me disiloxane and vanillin. The curing behaviors, kinetics, and thermal and thermomech. characteristics of the TSOP monomer and its polymer (poly(TSOP)) were analyzed by torque rheometry, differential scanning calorimetry (DSC), Fourier transformation IR spectroscopy (FTIR), thermogravity anal. (TGA), and dynamic thermal mech. anal. (DMA), resp. The non-isothermal curing kinetics results indicated that the cyano addition polymerization of the TSOP monomer was a self-catalytic reaction. The active hydrogen atoms from the secondary amino groups in the TSOP monomer could accelerate the crosslinking polymerization reaction of cyano groups, producing a decline in the curing temperature and a rise in the curing rate. Meanwhile, the TSOP monomer had a low melting temperature (77°C) and a wide process window (110°C) due to the introduction of flexible siloxane segments. The poly(TSOP) having phthalocyanine and a triazine ring exhibited a higher glass transition temperature (Tg) of 348°C and good thermal stability.

SDS of cas: 31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Category: nitriles-buliding-blocks.

Wang, Ting;Wang, Zi-long;Dayo, Abdul Qadeer;Shi, Cheng-yu;Liu, Hui-bo;Pan, Zhong-cheng;Gorar, Athar Ali Khan;Wang, Jun;Zhou, Heng;Liu, Wen-bin research published 《 Synthesis and properties of a novel autocatalytic phthalonitrile monomer and its copolymerization with multi-functional fluorene-based benzoxazine monomers》, the research content is summarized as follows. A novel autocatalytic phthalonitrile monomer [4,4′-(((((oxy-bis [4,1-phenylene]) bis (azanediyl)) bis (methylene)) bis (2-methoxy-4,1-phenylene)) bis (oxy)) diphthalonitrile, OPD] is obtained by nucleophilic substitution of 4-nitro-phthalonitrile and bisphenol compound [4,4′-(((oxy bis [4,1-phenylene]) bis (azanylylidene)) bis (methanylylidene)) bis (2-methoxyphenol)]. Bisphenol compound is a reductant with secondary amine groups of Schiff base derived from the reaction of vanillin and 4,4′-diaminodiphenylether. The OPD monomer has a self-catalytic polymerizing reaction. OPD monomer has good processability, and the processing window was 130°C. Moreover, OPD polymer [poly(OPD)] shows higher glass-transition temperature (345°C). The 5% and 10% thermal decomposition temperatures of poly(OPD) and char yield at 800°C are 407, 451°C, and 69%, resp. To further improve the properties of poly(OPD), the OPD monomer was modified by multi-functional fluorene-based benzoxazine monomers (MFFB) due to their excellent reaction activities. The results showed that OPD/MFFB systems had high reaction activities. The similar thermal stabilities between OPD and MFFB can give stable and excellent thermal stability to the poly(OPD/MFFB). Compared with poly(OPD), the Tg values of poly(OPD/MFFB) were significantly increased, and their stiffness values were reduced. The tensile, flexural, and impact properties for poly(OPD/MFFB) were improved significantly.

Category: nitriles-buliding-blocks, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts