Month: October 2022

In 2022,Luo, Yan; Li, Min; Tang, Jiaqi; Zang, Jianyang; Wang, Yonggang; Liu, Taihong; Fang, Yu published an article in Journal of Colloid and Interface Science. The title of the article was 《Interfacially confined preparation of fumaronitrile-based nanofilms exhibiting broadband saturable absorption properties》.Formula: C7H4FN The author mentioned the following in the article:

Interfacial nanofilms with nonlinear optical (NLO) properties were prepared via confined dynamic condensation of 4,4′-methylenedianiline (MDA) with the synthesized 2,3-bis(4-(bis(4-formylphenyl)amino)phenyl)fumaronitrile (BTFA). Investigated using the open-aperture Z-scan technique, BTFA showed reverse saturable absorption ascribed to the synergetic mechanisms of two-photon and excited-state absorption. In contrast, the as-prepared nanofilms demonstrated broadband saturable absorption within the spectral range of 720-1700 nm. The characteristics of nonlinear absorption coefficient (β) decreased along with increasing the incident pulse intensity. Taking advantage of the flexibility and post-machinability properties, the folding layers of the nanofilms offered the feasibility to fine-tune the specific NLO responses. The optimal β value was found to be -10.1 cm/MW for eight-layer nanofilm as well as the normalized transmittance increased up to 35-fold at 800 nm. Utilized as a conceptual saturable absorber, the representative modulation depth and saturation intensity were observed to be around 2.4% and 7.37 GW/cm2 at 800 nm, resp., comparable to traditional two-dimensional (2D) materials. Aiming to clarify the possible underlying phys. processes, a four-level model was employed to illustrate the fast relaxation of the excited states. Present work demonstrates that proper design of building blocks combined with interfacially confined dynamic condensation enables rational development of high-performance NLO materials. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzonitrile(cas: 1194-02-1Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Formula: C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Nishida, Yoshihide; Sato, Katsutoshi; Chaudhari, Chandan; Yamada, Hiroshi; Toriyama, Takaaki; Yamamoto, Tomokazu; Matsumura, Syo; Aspera, Susan Menez; Nakanishi, Hiroshi; Haneda, Masaaki; Nagaoka, Katsutoshi published an article in Catalysis Science & Technology. The title of the article was 《Nitrile hydrogenation to secondary amines under ambient conditions over palladium-platinum random alloy nanoparticles》.Synthetic Route of C7H4FN The author mentioned the following in the article:

Bimetalization between palladium (Pd) and platinum (Pt) nanoparticles, which resulted in a catalyst that showed high yield of secondary amines. Although Pd and Pt were thermodynamically immiscible, successfully alloyed the two metals by means of rapid chem. reduction assisted by microwave heating. X-ray absorption spectroscopy suggested the formation of heteroat. Pdδ+Ptδ- sites via charge transfer between neighboring Pd and Pt atoms in the alloy structure. Moreover, Fourier transform IR spectroscopy and scanning transmission electron microscopy-energy-dispersive X-ray spectroscopy indicated that decreasing the size of the PdPt (50 : 50) nanoparticles improved the degree of alloying and facilitated the formation of electron-enriched Ptδ- species. On the basis of kinetics studies and d. functional theory calculations, that cyano group activation, which was the rate-determining step over monometallic Pd and Pt catalysts, was accelerated over the heteroat. Pdδ+Ptδ- sites because of strong back-donation from electron-enriched Ptδ- species to the carbon atom of the cyano groups. The PdPt random alloy nanoparticles catalyzed the reactions of various aromatic and heterocyclic nitriles, and the corresponding secondary amines were selectively obtained in just a few hours. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 105942-08-3In 2018 ,《Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Sen, Tejosmita; Neog, Kashmiri; Sarma, Sangita; Manna, Prasenjit; Deka Boruah, Hari Prasanna; Gogoi, Pranjal; Singh, Anil Kumar. The article conveys some information:

Mycobacterium tuberculosis infection causes 1.8 million deaths worldwide, of which half a million has been diagnosed with resistant tuberculosis (TB). Emergence of multi drug resistant and extensive drug resistant strains has made all the existing anti-TB therapy futile. The major involvement of efflux pump in drug resistance has made it a direct approach for therapeutic exploration against resistant M. tuberculosis. This study demarcates the role of 11H-pyrido[2,1-b]quinazolin-11-one (quinazolinone) analogs as efflux pump inhibitor in Mycobacterium smegmatis. Sixteen quinazolinone analogs were synthesized by treating 2-aminopyridine and 2-fluorobenzonitrile with KtOBu. Analogs were tested, and 3a, 3b, 3c, 3g, 3j, 3l, 3m, and 3p were found to modulate EtBr MIC by >4 whereas 3a, 3g, 3i and 3o showed >4 modulation on norfloxacin MIC. 3l and 3o in addition to their very low toxicity they showed high EtBr and norfloxacin accumulation resp. Time kill curve showed effective log reduction in colony forming unit in presence of these analogs, thus confirming their role as efflux pump inhibitor. Through docking and alignment studies, we have also shown that the LfrA amino acid residues that the analogs are interacting with are present in Rv2333c and Rv2846c of M. tuberculosis. This study have shown for the first time the possibility of developing the 11H-pyrido[2,1-b]quinazolin-11-one analogs as efflux pump inhibitors for M. smegmatis and hence unbolts the scope to advance this study against resistant M. tuberculosis as well. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Related Products of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Related Products of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application In Synthesis of 4-Bromo-2-fluorobenzonitrileIn 2022 ,《From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor》 was published in Journal of Medicinal Chemistry. The article was written by Turner, Lewis D.; Trinh, Chi H.; Hubball, Ryan A.; Orritt, Kyle M.; Lin, Chi-Chuan; Burns, Julie E.; Knowles, Margaret A.; Fishwick, Colin W. G.. The article contains the following contents:

Fibroblast growth factor receptors (FGFRs) are implicated in a range of cancers with several pan-kinase and selective-FGFR inhibitors currently being evaluated in clin. trials. Pan-FGFR inhibitors often cause toxic side effects and few examples of subtype-selective inhibitors exist. Herein, we describe a structure-guided approach toward the development of a selective FGFR2 inhibitor. De novo design was carried out on an existing fragment series to yield compounds predicted to improve potency against the FGFRs. Subsequent iterative rounds of synthesis and biol. evaluation led to an inhibitor with nanomolar potency that exhibited moderate selectivity for FGFR2 over FGFR1/3. Subtle changes to the lead inhibitor resulted in a complete loss of selectivity for FGFR2. X-ray crystallog. studies revealed inhibitor-specific morphol. differences in the P-loop which were posited to be fundamental to the selectivity of these compounds Addnl. docking studies have predicted an FGFR2-selective H-bond which could be utilized to design more selective FGFR2 inhibitors. The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 17201-43-3In 2020 ,《Synthesis, molecular docking simulation, and biological evaluation studies of novel amide and ether conjugates of 2,3-diaryl-1,3-thiazolidin-4-ones》 was published in Journal of Heterocyclic Chemistry. The article was written by Daipule, Komal; Goud, Nerella Sridhar; Sethi, Aaftaab; Gurrapu, Swapna; Mamidala, Estari; Alvala, Mallika. The article contains the following contents:

To develop potent lead mols. as a novel class of reverse transcriptase (RT) inhibitors, amide and ether conjugates of 2,3-diaryl-1,3-thiazolidin-4-ones I (R1 = Ph, 2-BrC6H4, 2,3-Me2C6H3, 2-pyridyl, etc.) and II (R2 = H2C:CHCH2, HCCCH2, PhCH2, 3-ClC6H4CH2, etc.) were synthesized. The compounds II (R2 = PhCH2) and II (R2 = 4-FC6H4CH2) exhibited IC50 values of 0.21113 ± 0.013μM and 12.6804 ± 0.062μM resp. from the in-vitro human immunodeficiency virus type 1 (HIV-1) RT assay. None of the compounds showed toxicity towards peripheral blood mononuclear cells (PBMC). Structure-activity relationship (SAR) studies were performed for the synthesized compounds I and II in order to estimate the effect of the substitution pattern on the RT inhibition potency. In silico docking studies revealed that two or more interactions were necessary for significant activity. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Application of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Characteristics of the formation and toxicity index of nine newly identified brominated disinfection byproducts during wastewater ozonation》 was written by Zhang, Xin-Yang; Du, Ye; Lu, Yao; Wang, Wen-Long; Wu, Qian-Yuan. Related Products of 31938-07-5This research focused onwastewater ozonation brominated disinfection byproduct toxicity index; Bromide; DBPs; Formation potential; Ozonation; Toxicity index. The article conveys some information:

Ozonation plays an important role in wastewater treatment for reuse. However, the toxicity of wastewater treated with ozone considerably increases with bromide (Br-) concentration >100μg/L. Nine newly identified brominated disinfection byproducts (Br-DBPs) that are highly toxic in ozonated Br–containing wastewater were found in our recent work, including 2-bromostyrene, 1-bromo-1-phenylethylene, 2-bromobenzaldehyde, 3-bromobenzaldehyde, 4-bromobenzaldehyde, 2-bromophenylacetonitrile, 3-bromophenylacetonitrile, 4-bromophenylacetonitrile, and 2,4,6-tribromophenol. In the present study, the formation and calculated toxicity index of the nine newly identified Br-DBPs were evaluated. The correlations between the water quality index and the formation of nine Br-DBPs were also analyzed. With the increase of ozone dosage, the concentrations of bromostyrenes, 3-bromobenzaldehyde, 4-bromobenzaldehyde, 2-bromophenylacetonitrile, and 2,4,6-tribromophenyl in the ozonated samples gradually increased. With the increase of Br- concentration, the concentrations of bromostyrene, 2-bromobenzaldehyde, and 2,4,6-tribromophenol gradually increased. With the increase of NH4+ concentration, the concentrations of bromophenylacetonitriles gradually increased. Among the nine Br-DBPs, the bromophenylacetonitriles and 2,4,6-tribromophenol contributed the most to the cytotoxicity index, 2,4,6-tribromophenol and bromostyrenes contributed the most to the genotoxicity index, and bromophenylacetonitriles and bromostyrenes contributed the most to the oxidative damage index. The dissolved organic carbon levels strongly correlated with the formation of 3-bromophenylacetonitrile and 4-bromophenylacetonitrile, and the fluorescence I-V region intensity integral was correlated with the formation of 4-bromobenzaldehyde and 2,4,6-tribromophenol. The results of the present study clarified the formation potential of the nine widely existing newly identified Br-DBPs, confirmed the high calculated toxicity indexes, and are of great value for future research on Br-DBPs.2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Related Products of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Heteroatom-directed metalation. Lithiation of N-propenylbenzamides and N-propenyl-o-toluamides. Novel routes to ortho-substituted primary benzamide derivatives and N-unsubstituted isoquinolin-1(2H)-ones》 was written by Fisher, Lawrence E.; Muchowski, Joseph M.; Clark, Robin D.. HPLC of Formula: 53005-44-0 And the article was included in Journal of Organic Chemistry on April 24 ,1992. The article conveys some information:

Reaction of N-propenylbenzamides obtained by LDA-induced isomerization of the corresponding N-allylbenzamides with 2 equiv of sec-BuLi or tert-BuLi at low temperature regiospecifically generates the highly reactive N,ortho-dilithiated species. These dilithio species react with numerous electrophilic reagents, including alkyl halides, giving adducts which on hydrolysis with warm 50% aqueous acetic acid are converted into ortho-substituted primary benzmides in excellent yields. ortho-Lithiation of N-propenylbenzamides is thus formally equivalent to ortho-lithiation of primary benzamides. The utility of this synthetic operation is exemplified by the synthesis of 2-methoxy-6-methylbenzoic acid and 2-methoxy-6-methylbenzonitrile from N-propenyl-2-methoxybenzamide. After reading the article, we found that the author used 2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0HPLC of Formula: 53005-44-0)

2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. HPLC of Formula: 53005-44-0 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Negative pressure effects on molecular dynamics and phase diagram of glass-forming nematic liquid crystal 4-cyano-3-fluorophenyl 4-butylbenzoate (4CFPB) confined in nanopores》 was written by Rozwadowski, Tomasz; Massalska-Arodz, Maria; Jasiurkowska-Delaporte, Malgorzata. COA of Formula: C18H16FNO2 And the article was included in Journal of Molecular Liquids on April 1 ,2019. The article conveys some information:

Here, we show the method to determine the pressure conditions for liquid crystal restricted in nanochannels. For this purpose, broadband dielec. spectroscopy studies of 4CFPB glass-forming nematic liquid crystal at various pressure conditions and confined in non-intersecting nanopores of mean diameters 6 nm and 8 nm were combined. The pressure dependence of 4CFPB clearing point occurred to be linear and enabled to find pressure conditions in restricted spatial geometry. The pressure evolution of glass transition temperature was non-linear and was described well using the Andersson-Andersson law. Based on the presented results, the temperature-pressure phase diagram was constructed. In the part of experimental materials, we found many familiar compounds, such as 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5COA of Formula: C18H16FNO2)

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).COA of Formula: C18H16FNO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Organophotoredox-Catalyzed Reductive Tetrafluoroalkylation of Alkenes》 was published in Journal of Organic Chemistry in . These research results belong to Kostromitin, Vladislav S.; Levin, Vitalij V.; Dilman, Alexander D.. Electric Literature of C43H30F2N4 The article mentions the following:

A method for the hydroperfluoroalkylation of alkenes with 1,2-dibromotetrafluoroethane leading to tetrafluorinated bromides is described. The reaction is conveniently performed under blue light irradiation using an organic photocatalyst and ascorbic acid as a reducing agent. Primary products can be further functionalized via radical pathways affording various tetrafluorinated compounds The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Electric Literature of C43H30F2N4)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Electric Literature of C43H30F2N4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Stacking MFI zeolite structures for improved Sonogashira coupling reactions》 was written by Jia, Xicheng; Jiang, Dahong; Tsang, Daniel C. W.; Choi, Jungkyu; Yip, Alex C. K.. HPLC of Formula: 2042-37-7This research focused onZSM5 stacking support palladium catalyst preparation crystallinity; phenylacetylene bromobenzene palladium catalyst Sonogashira coupling; diphenylacetylene preparation. The article conveys some information:

A zeolite with stacking structure was designed by using hydraulic pressing and programmed temperature calcination synthesis procedures. ZSM-5 type zeolites with particle sizes of approx. 100 nm, 1 μm and 2 μm were used to synthesize stacking ZSM-5 with a size ranging from 45 to 63 μm. The prepared ZSM-5 zeolite stacking structure was used as a support to deposit palladium. The performance of the palladium/stacking ZSM-5 was investigated on Sonogashira coupling reactions. Stacking samples with micro-sized units (1 μm and 2 μm) showed a 200-300% higher turnover number (TON) than their unit counterparts. However, stacking samples with nano-sized units (100 nm) showed decreased TON conversion compared with that of their unit counterparts, probably due to partial destruction of the nano-sized ZSM-5 structure during the stacking synthesis process at high temperature The palladium/stacking ZSM-5 (micro-sized units) also showed better conversion on different bromides and alkynes than that of traditional homogenous catalysts. Moreover, the stacking composites showed good durability by recycling 4 runs without losing significant catalytic activity. The design of the stacking MFI structure exhibited improved catalytic activity, sustainability and hierarchical-resemblance properties. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7HPLC of Formula: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.HPLC of Formula: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts