On September 10, 1982, Colvin, Ernest W.; Kirby, Gordon W.; Wilson, Arthur C. published an article.Category: nitriles-buliding-blocks The title of the article was O-(Diphenylphosphinyl)hydroxylamine: a new reagent for electrophilic C-amination. And the article contained the following:
Ph2P(O)ONH2 (I) efficiently aminated (EtO)2P(O)CH-CO2CH2Ph, (EtO2C)2CH-, (NC)2CH-, PhMgBr, and Me(CH2)5MgBr in THF at -78掳 under Ar. E.g., treatment of (EtO)2P(O)CH2CO2CH2Ph with NaH at room temperature under Ar, then I at -78掳 gave 60% (EtO)2P(O)CH(NH2)CO2CH2Ph. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks
The Article related to phosphinylhydroxylamine amination phosphonoacetate malonate anion, grignard reagent amination phosphinylhydroxylamine, hydroxylamine phosphinyl amination phosphonoacetate anion and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts