Shey, Chun Feng; Chen, Chao Tung; Horng, Jhy Ming; Wang, Cheng Hsia published an article in 1984, the title of the article was Synthesis of 2,4-diamino-6-substituted pteridine.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:
Title compounds I (R = Cl, OH), intermediates for methotrexate, were prepared Thus, cyclocondensation of 2,4,5,6-tetraaminopyrimidine with CO(CH2OH)2 gave I (R = OH) whereas cyclocondensation of 2-amino-3-cyano-5-chloromethylpyrazine with guanidine gave I (R = Cl). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate
The Article related to aminopteridine, pteridine diamino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts