On June 11, 2020, Vacca, Joseph P.; Wager, Travis T. published a patent.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile The title of the patent was Preparation of substituted sulfonamido benzamides for the treatment of various diseases. And the patent contained the following:
The invention relates to preparation of substituted sulfonamido benzamides(I) for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmol. diseases, and viral infections. Compounds I wherein ring A is aryl or heteroaryl; R1 is H, C1-6 alkyl or C1-6 haloalkyl; R2 is C1-6 alkyl or C1-6 alkenyl, C1-6 heteroalkyl, etc.; R3-R5 each independently is H, halo, C1-6 alkyl; R6 is (un)substituted C1-6 alkyl; R7 is C1-6 alkyl, etc., are clamed. The example compound II was prepared using f 5-amino-2-chloro-benzoic acid as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I can be used in treatment of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmol. diseases, and viral infections. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
The Article related to sulfonamido benzamide preparation neuroprotectant antitumor antiviral ophthalmol musculoskeletal drug, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts