On April 30, 2003, Ali, Gameel A. M. El-Hag published an article.Name: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Studies on Thiazolopyridines. Part 3: Reactivity of Thiazolo[3,2-a]-3-aza[1,8]naphthyridine Towards Some Nucleophiles. And the article contained the following:
A variety of new thiazolo[3,2-a]pyridine derivatives having 3-indolyl group were produced by refluxing thiazolinone derivative with different benzylidenemalononitrile derivatives Reactivity of Thiazolo[3,2-a]-3-aza[1,8]naphthyridine (I) toward some nitrogen nucleophiles was investigated. Thus, the novel pyrazoles were obtained when I was allowed to react with hydrazine and Ph hydrazine in ethanol under reflux. On the other hand, pyrazolo[3′,4′:4,5]thiazolo[3,2-a]-3-aza[1,8]naphthyridine was formed by condensation of I with benzoyl hydrazine. Finally, condensed heterocyclic compounds containing pyran rings were obtained by treatment I with active ethylene compounds Antimicrobial activity of some of the product was also evaluated. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile
The Article related to thiazolopyridine derivative preparation reactivity nucleophile antimicrobial activity, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts