Armarego, Wilfred L. F. published an article in 1977, the title of the article was Pterins. Part 2. Stereochemistry of catalytic reduction of 6-methyl- and 6,7-dimethyl-pterin and of 2,4-diamino-6-methylpteridine.Category: nitriles-buliding-blocks And the article contains the following content:
Catalytic addition of 2 mols. of H to 7-deuterio-6-trideuteriomethylpterin gave a 0.8:1 mixture of cis- and trans-7-deuterio-6-trideuteriomethyl-5,6,7,8-tetrahydropterin. Similar reduction of 2,4-diamino-7-deuterio-6-(partial)trideuteriomethylpteridine gave a 1:1 mixture of cis- and trans-2,4-diamino-7-deuterio-6-(partial)trideuteriomethyl-5,6,7,8-tetrahydropteridine. However, catalytic reduction of 6,7-dimethyl- and 6,7-bis(trideuteriomethyl)pterin is stereospecific and gave only the cis 5,6,7,8-tetrahydro derivatives Reduction of 6,7-dimethylpterin with Na in EtOH gave a 1:1 mixture of cis- and trans-6,7-dimethyl-5,6,7,8-tetrahydropterin. The stereochem. of the products was deduced from 1H NMR spectroscopy. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks
The Article related to catalyst reduction stereochem pterin, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts