On December 27, 2018, Du-Cuny, Lei; Xiao, Qitao; Xun, Guoliang; Zheng, Qiangang published a patent.Product Details of 1036991-35-1 The title of the patent was Preparation of substituted 5-cyanoindole compounds for the treatment of lysine (K)-specific demethylase 1A mediated diseases. And the patent contained the following:
A compound of formula I, or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) – mediated diseases or disorders. Compounds of formula I wherein R1 is substituted C1-6 alkyl, substituted C3-6 cycloalkyl, substituted 7- to 11-membered spirocyclyl, etc.; R2 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; R3 is (un)substituted aminophenyl, (un)substituted aminopyridinyl, (un)substituted indolinyl, etc.; R4 is H, halo and C1-4 alkyl; R5 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their LSD1 modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.010 μM. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Product Details of 1036991-35-1
The Article related to cyanoindole preparation lsd1 modulator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 1036991-35-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts