On December 31, 2018, Dyachenko, V. D.; Matusov, I. O.; Dyachenko, I. V.; Nenajdenko, V. G. published an article.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Knoevenagel Reactions of Indole-3-carbaldehyde. Synthesis of 3-Substituted Indole Derivatives. And the article contained the following:
The Knoevenagel condensations of 1H-indole-3-carbaldehyde with various CH acids gave a number of substituted 3-(1H-indol-3-yl)acrylonitriles and acrylamides which were alkylated to afford the corresponding N-alkyl derivatives I [R = CN, CO2(CH2)6CH3, C(O)NHc-Pr; R1 = Me, allyl, Bn, etc.]. The latter were used as Michael acceptors in the synthesis of 4H-pyran, pyridine, 5,6,7,8-tetrahydroquinoline and [1,3]thiazolo[3,2-a]pyridine derivatives containing an indole fragment. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Reference of 2-((1H-Indol-3-yl)methylene)malononitrile
The Article related to indole preparation, nitrile indole knoevenagel condensation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts