On August 5, 2021, Lamotte, Yann; Dodic, Nerina; Tap, Aurelien; Denis, Alexis; Brusq, Jean-Marie; Daoubi Khamlichi, Mourad; Benderitter, Pascal Andre Rene published a patent.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile The title of the patent was Preparation of macrocyclic RIP2-kinase inhibitors. And the patent contained the following:
The invention relates to macrocyclic compounds of formula I and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2-kinase, and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the invention provides methods of using said compounds, for instance as a medicine or diagnostic agent. Compounds of formula I, wherein R1 is halo, alkynyl, CN, etc.; R2 and R10 are independently H and halo; R3, R3′, R4, R4′, R7 and R8 are independently H and C1-6 alkyl; R5 is OH, halo, CN, etc.; R6 is H, halo, C1-6 alkyl, etc.; R9 is H, C1-6 alkyl, COC1-6alkyl, etc.; and stereoisomers, tautomers, racemates, salts, hydrates, N-oxide forms, and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their RIP-2 kinase inhibitory activities (some data given). The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
The Article related to macrocycle rip2 kinase inhibitor preparation diagnostic treatment, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts