On June 30, 1994, Mahboobi, Siavosh; Grothus, Goetz published an article.Category: nitriles-buliding-blocks The title of the article was 1,3-Dinitropropanes: intermediates to 1,3-diaminopropanes. And the article contained the following:
Reduction of malodinitriles RCH(CN)2 (R = di-p-anisylmethyl, 3-indolylmethyl) to the corresponding diamines does not work. Reduction of dinitro-2-(indol-3-yl)propanes and subsequent reaction with K2PtCl4 afforded dichloroplatinum(II) complexes I [R1 = H, Me, Et; R2 = H, Me, Ph; R3 = H (17); R1 = Et, R2 = 4-HOC6H4, R3 = 5- or 6-HOC6H4]. Complexes 17 show weak binding affinities to the estrogen receptor and no antitumor activity towards MCF-7- and MDA-MB-2231-cell lines. Two-fold addition of nitromethane to the aldehyde function is possible. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Category: nitriles-buliding-blocks
The Article related to indolylpropanediamine preparation reaction, propanediamine indolyl, platinum indolylpropanediamine preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts