On March 28, 2012, Spencer, John; Patel, Hiren; Amin, Jahangir; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Furman, Christophe; Mansouri, Roxane; Chavatte, Philippe; Millet, Regis published an article.Category: nitriles-buliding-blocks The title of the article was Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. And the article contained the following:
A 2-substituted 5-aminooxazole-4-carbonitrile library has been synthesized and modified via microwave-mediated and flow chemistries. One synthesized compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks
The Article related to aminooxazolecarbonitrile library preparation reaction, oxazolecarbonitrile amino library preparation reaction, cannabinoid receptor affinity aminooxazolecarbonitrile, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts