Taylor, Edward C.; Portnoy, Robert C.; Hochstetler, Douglass C.; Kobayashi, T. published an article in 1975, the title of the article was Pteridines. XXXVIII. Synthesis of some 2,4-diamino-6-substituted methylpteridines. New route to pteroic acid.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:
6-Substituted 2,4-diaminopteridines I and 6-substituted pterins II (R = Cl, OH, H, p-ClC6H4, p-EtO2CC6H4NH, PhCH2, etc.) were prepared by reaction of 2-amino-3-cyano-5-chloromethylpyrazine with nucleophiles, followed by ring closure with guanidine to give I, and final acid hydrolysis to II. The pyrazine oxides III (R = PhCH2S, p-O2NC6H4NMe, p-O2NC6H4NH) were prepared by treating XCH2COCH:NOH (X = Cl, Br) with H2NCH(CN)2.p-MeC6H4SO3H and nucleophiles. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate
The Article related to pteridine diamino, pterin, cyclization cyanoaminopyrazine guanidine, pyrazine cyclization guanidine, pyruvaldehyde oxime cyclization aminomalononitrile, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts