On December 30, 2021, Vu, Binh; Dominique, Romyr; Li, Hongju; Fahr, Bruce; Chen, Yi published a patent.COA of Formula: C13H17BN2O2 The title of the patent was Methods and aromatic compounds for restoring mutant p53 function and their preparation. And the patent contained the following:
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The disclosure describes compounds of formula I and methods that restore DNA binding affinity of p53 mutants. The compounds of the disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds of formula I can be used to reduce the progression of cancers that contain a p53 mutation. Compounds of formula I wherein X1 is CR7 and N; X2 is CR2 and N; R1 and R2 are independently alkyl, NR8R9, CONR8R9, NHCOR9, etc.; Q is NHCH2C(:CH2)CONH2, NHCOCH:CH2, NHCH2C(:CH2)CN, etc.; R5 is H, halo, (un)substituted aryl, (un)substituted heteroaryl, etc.; R6 is (un)substituted (mono/bi)cyclic aryl and (un)substituted (mono/bi)cyclic heteroaryl; R7, R8 and R9 are independently (un)substituted alkyl, (un)substituted alkenyl, (un)substituted cycloalkyl, etc.; and with provisions; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their DNA binding affinity of mutant p53 protein. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).COA of Formula: C13H17BN2O2
The Article related to aromatic compound preparation restore mutant p53 function, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C13H17BN2O2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts