On August 11, 2022, Zhai, Wenqiang; Zhang, Zhimin; Pan, Hao; Wang, Zhe; Guo, Liubin; Zhang, Yuren; Liu, Dongzhou published a patent.Category: nitriles-buliding-blocks The title of the patent was Pyrrolopyridazine compound, and preparation method therefor and use thereof. And the patent contained the following:
The present invention relates to a pyrrolopyridazine compound as represented by a formula I [wherein X = C or N; R1 = H, halo, alkyl, alkenyl, etc.; Y = H, halo, OH, NH2, etc.; R3 = H, halo, alkyl, alkenyl, etc.; L2 = a single bond, CO, alkylene, etc.; Cy2 = cycloalkylene, heterocyclylene, O, etc.; R6 = independently halo, OH, NH2, CN, etc.; L3 = a single bond, O, or alkylene; Cy3 = cycloalkyl, heterocyclyl, aryl, or heteroaryl; R8 = independently H, halo, alkyl, etc.; m = 0-4; p = 0-3; with provisos] or a pharmaceutically acceptable salt thereof, and also relates to a pharmaceutical preparation, a pharmaceutical composition and the use thereof, wherein the compound can be used for the preparation of drugs for treating or preventing related diseases mediated by HPK1. For example, II was prepared in a multi-step synthesis. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Category: nitriles-buliding-blocks
The Article related to pyrrolopyridazine hpk1 treatment cancer human, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts