Bizzarri, Bruno Mattia; Fanelli, Angelica; Botta, Lorenzo; De Angelis, Marta; Palamara, Anna Teresa; Nencioni, Lucia; Saladino, Raffaele published an article in 2021, the title of the article was Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:
Amino imidazole carbonitrile derivatives decorated with α-amino acid side-chains have been synthesized by a multicomponent microwave assisted reaction inspired by the prebiotic chem. of aminomalononitrile as a tool for generating high chem. diversity. These compounds were used as annulation synthons for the preparation of 8,9-disubstituted-6,9-dihydro-1H-purin-6-ones by reaction with formic acid as a simple C-1 donor reagent. The novel heterocycles were characterized by significant activity against influenza A virus, amino imidazole carbonitrile derivatives showing the highest activity. Thus, the chem. complexity generated by prebiotic chem. furnished a general tool for the identification of novel antiviral agents. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate
The Article related to imidazole purine derivative aminomalononitrile prebiotic chem antiinfluenza virus activity, Placeholder for records without volume info and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts