Arita, Mao published the artcileThree Step Synthesis of Fully and Differently Arylated Pyridines, Synthetic Route of 100-70-9, the main research area is arylated pyridine synthesis cyclocondensation pyridylenamine unsaturated ketone.
Condensation of β-(2-pyridyl)enamine and α,β-unsaturated ketone in the presence of FeCl3 under air afforded highly substituted pyridines. In this transformation, FeCl3 acted as not only an acid catalyst but also an oxidant for the intermediate dihydropyridine. The substituents could be easily modified by altering the substrates to obtain tri- and tetraarylpyridines including bipyridines and terpyridine. Synthesis of differently substituted pentaarylpyridines was consequently achieved via only three steps from com. available reagents with simple exptl. manipulations. Thus, e.g., enamine I + benzylideneacetone â?II (84%).
European Journal of Organic Chemistry published new progress about Aldol condensation (for preparation of α,β-unsaturated ketones). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts