Goeker, Hakan published the artcileSynthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles, COA of Formula: C7H5N3O2, the main research area is benzimidazole preparation nucleophilic substitution reduction aryl diamine benzaldehyde heterocyclization; fungal infection antifungal structure activity Candida.
A series of 47 novel N1-alkylated-2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogs were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that I and II, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogs III (R1 = H, R2 = Br; R1 = Pr, R2 = Br, CN) have no inhibitory activity.
Journal of Heterocyclic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 87331-46-2 belongs to class nitriles-buliding-blocks, name is 2-Amino-3-nitrobenzonitrile, and the molecular formula is C7H5N3O2, COA of Formula: C7H5N3O2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts