Li, Yajuan published the artcileCatalytic Asymmetric Reductive Azaarylation of Olefins via Enantioselective Radical Coupling, Recommanded Product: Picolinonitrile, the main research area is azaarene enantioselective preparation; acrylophenone cyanopyridine irridium photocatalyst reductive azaarylation; pyridinyl chromanone enantioselective preparation; cyanopyridine flavone irridium photocatalyst reductive azaarylation.
Herein, chiral hydrogen-bonding/photosensitizer catalysis found a viable platform as it enabled the realization of the first enantioselective manifold. A variety of acyclic and cyclic enones as the reaction partners were compatible with the dual catalyst system, leading to a wide array of valuable enantioenriched azaarene variants I [Ar = Ph, 2-naphthyl, 2-furanyl, etc.; R = Me, i-Pr, Ph, etc.] and II [X = O, S; R1 = H, 5-Cl, 6-Me, etc.; R2 = Me, Ph, 2-FC6H4, etc.; R3 = 4-pyridyl, 2-methylpyridin-4-yl, 2,6-dimethylpyridin-4-yl, etc.] with high yields and ees. Regulating the types of chiral catalysts represented one of the important manners to success, in which several readily accessible Cinchona alkaloid-derived bifunctional catalysts were introduced in asym. photochem. reactions.
Journal of the American Chemical Society published new progress about Arylation catalysts. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts