Sharma, Anindra published the artcileDesign, synthesis and evaluation of thiazole based amides for their antitubercular and PknG inhibitory activity, Computed Properties of 91-15-6, the main research area is thiazole amide preparation antitubercular Mycobacterium tuberculosis; serine threonine protein kinase G inhibitor; aminothiazole aromatic heteroaromatic acid coupling.
A series of thiazole based amides have been designed and synthesized by solution-phase amide coupling of 2-aminothiazole and its derivatives with naturally occurring aromatic and heteroaromatic acids in excellent yield via DIC/HOBt protocol. All the compounds have been evaluated for their antitubercular activity against M. tuberculosis virulent strain M. tuberculosis H37Rv and PknG inhibitory activity in the presence and absence of the inhibitors. The compounds display moderate to significant PknG inhibitory activity (9.1-15.6% inhibition at 100μM) as compared to the standard inhibitors and very moderate in vitro antitubercular activities against M. tuberculosis virulent strain M. tuberculosis H37Rv.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts