Li, Hanning published the artcileTriarylamine-based porous coordination polymers performing both hydrogen atom transfer and photoredox catalysis for regioselective α-amino C(sp3)-H arylation, Safety of Phthalonitrile, the main research area is triarylamine based porous coordination polymer photocatalyst preparation; benzylamine regioselective preparation; amine benzonitrile alpha amino CH arylation coordination polymer photocatalyst.
Herein, a heterogeneous approach to combination of hydrogen atom transfer (HAT) and photoredox catalysis for regioselective C-H arylation of benzylamines was presented. The different mol. sizes and coordination modes of ligands, tricarboxytriphenylamine (H3TCA) and tris(4-(pyridinyl)phenyl)amine (NPy3), in one coordination polymer consolidated triarylamine (Ar3N) moiety into a special structural intermediate, which enhanced chem. and thermal stability of polymers and diminished structural relaxation during catalytic process. The inherent redox potentials of Ar3N moieties prohibited in situ formed Ar3N ·+ to earn an electron from C(sp3)-H nucleophiles, but allowed abstraction of a hydrogen atom from C(sp3)-H nucleophiles, enabling formation of C(sp3) · radical and cross-coupling reaction to proceed at most electron-rich sites with excellent regioselectivity. The new heterogeneous photoredox HAT approach skipped several interactions between transient species during typical synergistic SET/HAT cycles, demonstrating a promising redox-economical and reagent-economical heterogeneous platform that had not been reported for α-amino C-H arylation to form benzylamine derivatives Control experiments based on monoligand coordination polymers suggested that mixed-ligand approach improved photochem. and photophys. properties, providing important insight into rational design and optimization of recyclable photocatalysts for rapid access to complex bioactive mols. and late-stage functionalized pharmaceuticals.
Chemical Science published new progress about Arylation catalysts (photochem., regioselective). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts