Muddagoni, Narasimha published the artcileTin ( IV ) chloride catalyzed one-pot synthesis, characterization and docking studies of 4-aminoquinoline derivatives as Myt1 inhibitors, Formula: C7H6N2, the main research area is amino benzonitrile aryl methanone tin chloride catalyst heterocyclization; aryl aminoquinoline preparation mol docking.
An efficient and practical method for the series of 4-aminoquinoline derivatives I [R = 3-cyanophenyl, 2,3-dihydro-1H-inden-5-yl, 5-chlorothiophen-2-yl, etc.; R1 = H, Cl] was developed via Tin (lV) chloride catalyzed cascade cyclization from 2-aminobenzonitrile and different acetophenones. These novel chem. entities I were characterized by their 1HNMR, 13CNMR spectra and high-resolution mass spectrometer (HRMS) with their docking studies were performed to identify potential inhibitors of Myt1kinase protein. The synthesized analogs I were docked with Myt1 kinase protein. Among these, compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] were showing promising Glide score, prime-MMGBSA and ADME properties similar to Neratinib, Pelitinib cancer inhibiting drugs of Myt1 kinase protein. The amino acid ASP251of Myt1 kinase protein was consistently binding to novel chem. entities I and existing drugs, indicating that the amino acid is crucial and responsible for its inhibition. Docking studies revealed that the compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] indicated that they can act as strong inhibitors of Myt1 kinase protein as that of comparable existing drugs Neratinib, Pelitinib.
Journal of Heterocyclic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts