Wang, Menglan published the artcileIron-promoted construction of indoles via intramolecular oxidative C-N coupling of 2-alkenylanilines using persulfate, COA of Formula: C7H6N2, the main research area is indole preparation; alkenylaniline intramol oxidative coupling iron catalyst.
Without N-protection, readily prepared 2-alkenylanilines were transformed into indoles I [R1 = H, Me, 3-MeC6H4, etc.; R2 = H, Me, Et; R3 = H, 5-Me, 5-Cl] in good yields via intramol. oxidative C-N coupling using K2S2O8 as oxidant in the presence of catalytic amounts of FeF2. The K2S2O8/FeF2 system offered direct and benign synthetic route to compounds I and it is applicable to wide range of substituted indoles including drug intermediates. The advantages of this protocol were cheap reagents, no N-protection, mild conditions and good group tolerance.
Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (alkenyl-). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts