Chang, Guoliang published the artcileLewis acid promoted dehydration of amides to nitriles catalyzed by [PSiP]-pincer iron hydrides, Product Details of C6H4N2, the main research area is phosphorus silicon iron hydrido pincer ligand preparation crystal structure; aryl nitrile preparation; amine aryl dehydration Lewis acid promoted iron catalyst.
The dehydration of primary amides to their corresponding nitriles using four [PSiP]-pincer hydrido iron complexes [(2-Ph2PC6H4)2MeSiFe(H)(PMe3)2, (2-Ph2PC6H4)2HSiFe(H)(PMe3)2, (2-(iPr)2PC6H4)2HSiFe(H)(PMe3)2 and (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2] as catalysts in the presence of (EtO)3SiH as dehydrating reagent was explored in the good to excellent yields. It was proved for the first time that Lewis acid could significantly promote this catalytic system under milder reaction conditions than other Lewis acid-promoted system, such as shorter reaction time or lower reaction temperature This was also the first example that dehydration of primary amides to nitriles RCN [R = 4-ClC6H4, 2-thienyl, Bn, etc.] was catalyzed by silyl hydrido iron complexes bearing [PSiP]-pincer ligands with Lewis acid as additive. This catalytic system had good tolerance for many substituents. Among the four iron hydrides (2-Ph2PC6H4)2MeSiFe(H)(PMe3)2 was the best catalyst. The effects of substituents of the [PSiP]-pincer ligands on the catalytic activity of the iron hydrides were discussed. A catalytic reaction mechanism was proposed. Complex (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2 was a new iron complex and was fully characterized. The mol. structure of complex (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2 was determined by single crystal X-ray diffraction.
Applied Organometallic Chemistry published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts