Chen, Weiqiang’s team published research in Organic Chemistry Frontiers in 2021 | CAS: 1885-29-6

Organic Chemistry Frontiers published new progress about Benzamides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Chen, Weiqiang published the artcileSwitchable and efficient conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones and N-(2-chloroethyl)benzamides, COA of Formula: C7H6N2, the main research area is amidophenyloxazoline chemoselective reaction; chloroethylbenzamide preparation; quinazolinone preparation.

Switchable chemoselective conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones or N-(2-chloroethyl)benzamides was achieved. The former reaction was proposed to involve a PIFA-mediated 6π electrocyclization followed by an in situ nucleophilic substitution, while the latter reaction uses aluminum chloride as a halogenated source through a ring-opening reaction. The reactions proceed smoothly under mild conditions and have excellent functional group compatibility.

Organic Chemistry Frontiers published new progress about Benzamides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts