Uengoeren, S. Hakan published the artcileThe Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β-Ketoamides, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is isocytosine preparation; ketoamide cyanamide cyclization tandem reaction diazabicycloundecene catalyst.
A method for the synthesis of isocytosine analogs I (R = H, 4-chlorophenyl, pyridin-2-yl, etc.), II, III (R1 = H, Cl) and IV (R2 = H, Cl, Br; R3 = Me, Ph, 4-methoxyphenyl, 3,4-dimethoxyphenyl) from β-ketoamides R4C(O)CH2C(O)NHR5 [R4 = Me, (4-methylphenyl)aminyl, Ph, etc.; R5 = H, 4-chloro-2-cyanophenyl, pyridin-2-yl, etc.] was investigated. Application of the method to β-ketoamides including a 2-cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 Examples of pyrimidone derivatives I, II, III and IV were synthesized in different patterns.
ChemistrySelect published new progress about Amides, oxo Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts