Zhao, Huantian published the artcileSynthesis of 1H-Indazoles and Quinazolines Using Additive Intermediates of Grignard Reagents to 2-Amino Benzonitriles, Category: nitriles-buliding-blocks, the main research area is aminobenzonitrile bromide iron chloride catalyst one pot heterocyclization; indazole preparation; bromide aminobenzonitrile ester bismuth chloride catalyst one pot heterocyclization; quinazoline preparation.
A convenient and efficient approach to 1H-indazoles in one-pot under air atm., using additive intermediates of Grignard reagents to 2-aminobenzonitriles via a FeCl3/Bpy catalyzed N-N coupling was developed. Besides, such intermediates could reacted with esters in one-pot to yield quinazolines promoted by BiCl3/Ph3P. Both 1H-indazoles and quinazolines were prepared in good to excellent yields. The possible mechanisms for the formation of 1H-indazoles and quinazolines were proposed.
ChemistrySelect published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts