Gao, Hongjie published the artcileBioinspired Iron-Catalyzed Dehydration of Aldoximes to Nitriles: A General N-O Redox-Cleavage Method, Recommanded Product: Picolinonitrile, the main research area is nitrile preparation chemoselective; aldoxime dehydration bioinspired iron catalyst; benzoisoxazole kemp elimination bioinspired iron catalyst; dehydration kemp elimination bioinspired iron catalyst.
An efficient iron catalyst, Cp*Fe(1,2-Cy2PC6H4O), which rapidly converts various aliphatic and aromatic aldoximes RCH=NOH [R = Pr, Ph, 2H-1,3-benzodioxol-5-yl, etc.] to nitriles RCN with release of H2O at room temp was reported. The catalysis involves redox activation of the N-O bond by a 1e- transfer from the iron catalyst to the oxime. Such redox-mediated N-O cleavage was demonstrated by the isolation of a ferrous iminato intermediate from the reaction of the ketoxime substrate. This iron-catalyzed acceptorless dehydration approach represents a general method for the preparation of nitriles, and it also delivers salicylonitriles R1CN(2-OH) [R1 = Ph, 3-methoxyphenyl, naphthalen-1-yl, etc.] catalyzing the Kemp elimination reaction.
Journal of Organic Chemistry published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts