Pieczykolan, Michal published the artcileAn Efficient Method for the Programmed Synthesis of Multifunctional Diketopyrrolopyrroles, Application In Synthesis of 100-70-9, the main research area is aldehyde primary amine nitrile diethyl oxalacetate diastereoselective cyclization fluorescence; diketopyrrolopyrrole preparation; donor-acceptor systems; dyes; fluorescence; heterocycles; lactams.
A new, transformative methodol. for the preparation of diketopyrrolopyrroles from aldehydes, primary amines, nitriles, and di-Et oxalacetate has been developed. It is now possible to prepare diketopyrrolopyrroles, e.g., I, bearing an ordered arrangement of three different substituents from abundant and com. available materials, allowing the independent regulation of all desired physicochem. properties. For the first time very electron-rich (carbazol-3-yl, dimethylaminophenyl, pyrrolo[3,2-b]pyrrolyl), and sterically hindered substituents (naphthalen-1-yl, quinolin-4-yl, acridin-9-yl, imidazo[1,5-a]pyridin-1-yl, 2-bromophenyl etc.) can be appended to the diketopyrrolopyrrole core by condensation of an appropriate nitrile with a pyrrolidin-2-one intermediate. Even greater synthetic possibilities are related to the fact that such demanding substituents as 4-dimethylaminophenyl, indol-3-yl, and 2-methoxyphenyl can be incorporated from aldehyde precursors, bypassing problems with the nitriles reactivity.
Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts