Ruan, Banfeng published the artcileSynthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is pyrrolidine oxadiazole preparation anthelmintic structure activity relationship; Anthelmintic; Drug discovery; Haemonchus contortus; Pyrrolidine-oxadiazoles; Structure-activity relationship.
Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause substantive socioeconomic losses due to the diseases that they cause. The control of nematodes in livestock animals relies heavily on the use of anthelmintic drugs. However, their extensive use has led to a widespread problem of drug resistance in these worms. Thus, the discovery and development of novel chem. entities for the treatment of parasitic worms of humans and animals is needed. Herein, authors describe the medicinal chem. optimization efforts of a phenotypic hit against Haemonchus contortus based on a pyrrolidine-oxadiazole scaffold I (R = H, 4-Cl, 3-OMe, etc.; R1 = 2-Me, 3-OH, 4-CN, etc.). This led to the identification of compounds with potent inhibitory activities (IC50 = 0.78-22.4μM) on the motility and development of parasitic stages of H. contortus, and which were found to be highly selective in a mammalian cell counter-screen. These compounds could be used as suitable chem. tools for drug target identification or as lead compounds for further optimization.
European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts